264 research outputs found
Effect of food on the pharmacokinetics of oral MMI270B (CGS 27023A), a novel matrix metalloproteinase inhibitor
MMI270B is a matrix metalloproteinase inhibitor (MMPI) with in vitro and
in vivo activity. To exert optimal target inhibition, MMPI must be given
chronically, and therefore, oral bioavailability is important. We analyzed
the effect of food intake on AUC0-8 h, Cmax, and Tmax. Seventeen patients
were entered into the study. Doses of MMI270B were 150, 400, and 600 mg.
The first day, patients ingested the drug in a fasted state and were not
allowed to eat for 2 h. The second day, patients ingested the drug 30 min
after a light breakfast. Mean AUC0-8 h was not significantly influenced by
food intake. Plasma concentrations were well above the IC50 of several
MMPs at all doses tested. Mean Cmax was significantly decreased after food
intake. Mean Tmax was significantly delayed after food intake. Food intake
did not result in a significant change in exposure to MMI270B (AUC0-8 h)
but did result in a significant, although not clinically relevant,
decrease in peak plasma levels and time to reach peak plasma levels. No
specific guidelines concerning the ingestion of MMI270B in either a fed or
a fasted state are recommended
Toroidal mode number estimation of the edge-localized modes using the KSTAR 3-D electron cyclotron emission imaging system
A new and more accurate technique is presented for determining the toroidal mode number n of edge-localized modes (ELMs) using two independent electron cyclotron emission imaging (ECEI) systems in the Korea Superconducting Tokamak Advanced Research (KSTAR) device. The technique involves the measurement of the poloidal spacing between adjacent ELM filaments, and of the pitch angle ?? O of filaments at the plasma outboard midplane. Equilibrium reconstruction verifies that ?? O is nearly constant and thus well-defined at the midplane edge. Estimates of n obtained using two ECEI systems agree well with n measured by the conventional technique employing an array of Mirnov coils.open3
Exploration of hyperfine interaction between constituent quarks via eta productions
In this work, the different exchange freedom, one gluon, one pion or
Goldstone boson, in constituent quark model is investigated, which is
responsible to the hyperfine interaction between constituent quarks, via the
combined analysis of the eta production processes,
and . With the Goldstone-boson exchange, as well as
the one-gluon or one-pion exchange, both the spectrum and observables, such as,
the differential cross section and polarized beam asymmetry, are fitted to the
suggested values of Particle Data Group and the experimental data. The first
two types of exchange freedoms give acceptable description of the spectrum and
observables while the one pion exchange can not describe the observables and
spectrum simultaneously, so can be excluded. The experimental data for the two
processes considered here strongly support the mixing angles for two lowest S11
sates and D13 states as about -30 and 6 degree respectively.Comment: 7 pages, 4 figures, 4 table
Evidence of the Purely Leptonic Decay B- --> tau- nu_tau-bar
We present the first evidence of the decay B- --> tau- nu_tau-bar using 414
fb^-1 of data collected at the Upsilon(4S) resonance with the Belle detector at
the KEKB asymmetric-energy e+e- collider. Events are tagged by fully
reconstructing one of the B mesons in hadronic modes. We detect the signal with
a significance of 3.5 standard deviations including systematics, and measure
the branching fraction to be Br(B- --> tau- nu_tau-bar) = (1.79
+0.56-0.49(stat) +0.46-0.51(syst))*10^-4. This implies that f_B = 0.229
+0.036-0.031(stat) +0.034-0.037(syst) GeV and is the first direct measurement
of this quantity.Comment: 6 pages, 3 figures, to appear in Physical Review Letter
Study of Decays
We report on a study of decays using
29.1 fb of annihilation data recorded at the
resonance with the Belle detector at the KEKB storage ring. Making no
assumptions about the intermediate mechanism, the branching fractions for
and are
determined to be and respectively. An analysis of candidates yields to the first observation of the color-suppressed
hadronic decay with the branching fraction . We measure the ratio of branching fractions
= 1.6 0.8.Comment: 13 pages, LaTex, 4 figures, submitted to Phys. Lett.
Observation of the Decays B0->K+pi-pi0 and B0->rho-K+
We report the observation of B^0 decays to the K^+pi^-pi^0 final state using
a data sample of 78 fb^-1 collected by the Belle detector at the KEKB e^+e^-
collider. With no assumptions about intermediate states in the decay, the
branching fraction is measured to be (36.6^{+4.2}_{-4.3}+- 3.0)*10^-6.We also
search for B decays to intermediate two-body states with the same K^+pi^-pi^0
final state. Significant B signals are observed in the rho(770)^- K^+ and
K^*(892)^+pi^- channels, with branching fractions of
(15.1^{+3.4+1.4+2.0}_{-3.3-1.5-2.1})* 10^-6 and
(14.8^{+4.6+1.5+2.4}_{-4.4-1.0-0.9})* 10^-6, respectively. The first error is
statistical, the second is systematic and the third is due to the largest
possible interference. Contributions from other possible two-body states will
be discussed. No CP asymmetry is found in the inclusive K^+pi^-pi^0 or rho^-K^+
modes, and we set 90% confidence level bounds on the asymmetry of
-0.12<A_{CP}<0.26 and -0.18<A_{CP}<0.64, respectively.Comment: 18 pages, 7 figure
Observation of Ds1(2536)+ -> D+pi-K+ and angular decomposition of Ds1(2536)+ -> D*+K0S
Using 462/fb of e+e- annihilation data recorded by the Belle detector, we
report the first observation of the decay Ds1(2536)+ -> D+pi-K+. The ratio of
branching fractions B(Ds1+ -> D+pi-K+)/B(Ds1+ -> D*+K0) is measured to be
(3.27+-0.18+-0.37)%. We also study the angular distributions in the Ds1(2536)+
-> D*+K0S decay and measure the ratio of D- and S-wave amplitudes. The S-wave
dominates, with a partial width of Gamma_S/Gamma_total=0.72+-0.05+-0.01.Comment: Submitted to Phys.Rev.D 16 pages, 6 figures, 3 table
Time-Dependent CP Violation Effects in Partially Reconstructed Decays
We report measurements of time-dependent decay rates for decays and extraction of CP violation parameters related to .
We use a partial reconstruction technique, whereby signal events are identified
using information only from the primary pion and the charged pion from the
decay of the . The analysis uses of data
accumulated at the resonance with the Belle detector at the KEKB
asymmetric-energy collider. We measure the CP violation parameters
and .Comment: 15 pages, 5 figures. To appear in Physics Letters
Measurement of the Branching Fraction for B->eta' K and Search for B->eta'pi+
We report measurements for two-body charmless B decays with an eta' meson in
the final state. Using 11.1X10^6 BBbar pairs collected with the Belle detector,
we find BF(B^+ ->eta'K^+)=(79^+12_-11 +-9)x10^-6 and BF(B^0 ->
eta'K^0)=(55^+19_-16 +-8)x10^-6, where the first and second errors are
statistical and systematic, respectively. No signal is observed in the mode B^+
-> eta' pi^+, and we set a 90% confidence level upper limit of BF(B^+->
eta'pi^+) eta'K^+- decays is
investigated and a limit at 90% confidence level of -0.20<Acp<0.32 is obtained.Comment: Submitted to Physics Letters
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