Arginine and Memory Consolidation in Praying Mantis

A praying mantis shown a bird displys a frightening responsa called deimatic reaction. Habituation of this response takes place after repeated presentations of the birs. Paper gel electrophoresis of a gel filtration of brain extracts tevealed three distinctive cationic spots. Change in the intensity of one of these spots proved to be clearly correlated with memory consolidation- Biochemical analysis of this spot indicated that it contains a mixture of lysine and arginine

Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis

Experimental cancer immunology and therap

Single-cell transcriptional diversity is a hallmark of developmental potential

Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular differentiation trajectories. However, inferring both the state and direction of differentiation is challenging. Here, we demonstrate a simple, yet robust, determinant of developmental potential-the number of expressed genes per cell-and leverage this measure of transcriptional diversity to develop a computational framework (CytoTRACE) for predicting differentiation states from scRNA-seq data. When applied to diverse tissue types and organisms, CytoTRACE outperformed previous methods and nearly 19,000 annotated gene sets for resolving 52 experimentally determined developmental trajectories. Additionally, it facilitated the identification of quiescent stem cells and revealed genes that contribute to breast tumorigenesis. This study thus establishes a key RNA-based feature of developmental potential and a platform for delineation of cellular hierarchies.Experimental cancer immunology and therap