40 research outputs found
ΠΠΈΠΎΠΊΠΈΠ½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ Π²ΡΡΠΎΠΊΠΈΡ Π΄ΠΎΠ· ΠΌΠ΅ΡΠΎΡΡΠ΅ΠΊΡΠ°ΡΠ°
Methotrexate is one of the most effective and widely used cytostatic drugs. However as all antineoplastic drugs it has very low therapeutic index and high toxicity. Kinetic parameters (rate constants, half-times of restoration and extreme values of concentrations at the beginning of methotrexate infusion) were estimated for biochemical markers It is the method of the quantitative assessment of the drug toxicity. The biokinetic findings allow to set an optimum time interval between infusions of methotrexate for minimization of toxicity at therapeutic efficacy keeping of the antineoplastic drug.ΠΠ΅ΡΠΎΡΡΠ΅ΠΊΡΠ°Ρ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΈ ΡΠΈΡΠΎΠΊΠΎ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ΅ΠΌΡΡ
ΡΠΈΡΠΎΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ². ΠΠ΄Π½Π°ΠΊΠΎ, ΠΊΠ°ΠΊ ΠΈ Π²ΡΠ΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ, ΠΎΠ½ ΠΈΠΌΠ΅Π΅Ρ Π½ΠΈΠ·ΠΊΠΈΠΉ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΈΠ½Π΄Π΅ΠΊΡ ΠΈ ΠΎΠ±Π»Π°Π΄Π°Π΅Ρ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΡΡ. ΠΠ°ΡΡ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ ΠΎΡΠ΅Π½ΠΊΡ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΠΌΠΎΠΆΠ½ΠΎ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡ ΠΊΠΈΠ½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ (ΠΊΠΎΠ½ΡΡΠ°Π½ΡΠ° ΡΠΊΠΎΡΠΎΡΡΠΈ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ ΠΈ ΠΏΠ΅ΡΠΈΠΎΠ΄ ΠΏΠΎΠ»ΡΠ²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ Π΄ΠΎ Π½ΠΎΡΠΌΡ, ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΏΠΎΡΠ»Π΅ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°) Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΊΡΠΎΠ²ΠΈ, ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΡΡ
Π΄Π»Ρ ΡΠΎΠ³ΠΎ ΠΈΠ»ΠΈ ΠΈΠ½ΠΎΠ³ΠΎ Π²ΠΈΠ΄Π° ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ. Π Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΠ΅ Π±ΡΠ» ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ Π±ΠΈΠΎΠΊΠΈΠ½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΠΌΠ΅ΡΠΎΡΡΠ΅ΠΊΡΠ°ΡΠ°. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π΄Π°ΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π΄ΠΎΠ·Ρ ΠΈ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΌΠ΅ΡΠΎΡΡΠ΅ΠΊΡΠ°ΡΠ° ΠΈ Π΅Π³ΠΎ Π°Π½ΡΠΈΠ΄ΠΎΡΠ° - Π»Π΅ΠΉΠΊΠΎΠ²ΠΎΡΠΈΠ½Π° Π΄Π»Ρ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΠΏΡΠΈ ΡΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΠΈ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ
PHYSICAL WORKING CAPACITY OF CHILDREN OF YOUNG SCHOOL AGES WHICH ARE SWIMMING
In this article, we study the effect of complexes impact on the
development of motor qualities, based on physical loads of varying
power and intensity, on the physical working capacity of pupils in
experimental group
Model of Development of Self-determination as the Basis of Prevention of Addictive Behavior of Adolescents in Contemporary Educational Organizations
The article presents the analysis of the current domestic research of the problem of self-determination. It is shown that adolescence is a sensitive period for the development of self-determination, but there are not enough studies of its dynamics at this age and ways of the formation. Self-determination is considered in the article as the opposite of addictive behavior, which makes it a resource in terms of prevention of pathological dependencies. Therefore, the proposed approach to optimization of the system of prevention in educational institutions through the development of self-determination in adolescence, based on the development of the spiritual fulfillment of the individual as the main stage of formation of the self. A model of interaction between education experts in the course of prevention of addictive behavior in educational organizations, reflecting the main stages of development of self-determination in the course of maintenance work
EFFECTIVENESS OF OBSERVATION OF CHILDREN WITH BRONCHIAL ASTHMA AND EVALUATION OF THEIR QUALITY OF LIKE BY ALLERGOLOGIST
(Voprosy sovremennoi pediatrii βΒ Current Pediatrics. β 2010;9(4):168-170
REGULAR OBSERVATION OF CHILDREN WITH BRONCHIAL ASTHMA BY ALLERGOLOGIST AND ITS INFLUENCE ON CLINICAL AND FUNCTIONAL PARAMETERS OF THE DISEASE AND CONSUMPTION OF HEALTHCARE RESOURCES
In real practice, treatment of patients with bronchial asthma (BA) is accompanied by unreasonable increase of healthcare resources consumption because of unplanned visits to the doctor due to health worsening, hospital treatment of exacerbations and emergency calls. Objective: to evaluate an effectiveness of childrenβs with bronchial asthma observations by allergologist. Methods: the dynamics of clinical and functional signs and frequency of emergency claims was analyzed in 115 children with BA who were observed by allergologist once in 3 months during one year. Results: in 3 months of regular observation by allergologist the number of children with day and night symptoms of BA and patients with daily rescue use of short-acting 2-agonists decreased, there were fewer children with limitations of physical activity. The number of patients with normal FEV1 increased in 6 months. Regular observation with allergologist resulted in reduction of number of patients with exacerbations and hospitalizations, shortening of acute period of BA and hospital stay, decreasing of emergency claims rate compared to those who were observed by GPs. Conclusion: regular observation by allergologist once in 3 months results in stabilization of clinical and functional state in patients with BA and decreases the consumption of emergency care resources.Key words: children, bronchial asthma, allergologist, clinical and functional state, healthcare resources.(Voprosy sovremennoi pediatrii β Current Pediatrics.Β 2011; 10 (3): 55β59)</span
EFFECTIVENESS OF OBSERVATION OF CHILDREN WITH BRONCHIAL ASTHMA AND EVALUATION OF THEIR QUALITY OF LIKE BY ALLERGOLOGIST
(Voprosy sovremennoi pediatrii βΒ Current Pediatrics. β 2010;9(4):168-170)</span
Mechanisms of the influence of electroinsulation coatings on the magnetic properties of amorphous soft magnetic alloys
The influence of organic and inorganic coatings on the magnetic properties of amorphous Fe-B-Si-C and Fe-Co-Si-B alloys were investigated. The samples of these alloys were in as-quenched state and after heat treatment with or without magnetic field. The morphology of researched coatings was different : amorphous and crystal. The suggested mechanism of the influence of coating is connected with appearance of anisotropic pseudo - uniaxial stresses in a plane of ribbon which are caused by anisotropic arrangement of coating elements in surface of ribbons
Complex program for the prevention of the development and progression of refractive errors in school year children
T.K. Botabekova1, N.A. Aldasheva2, V.R. Abdullina1, I.S. Stepanova1,
B.I. Isergepova2, Zh.S. Iskakbaeva2
1Kazakhstan-Russian Medical University, Almaty, Kazakhstan
2Kazakhstan Research Institute of Eye Diseases, Almaty, Kazakhstan
Aim: to develop a complex preventive and therapeutic program for refractive errors in school year children.
Patients and Methods: 1,760 pupils of elementary, secondary, and high school of eight schools of Almaty (1,302 pupils of gymnasiums and 458 pupils of general education schools and sport boarding school) were examined. The 1st step was a preventive screening. The 2nd step was a distant interactive screening by teachers. The 3rd step was an eye examination of schoolers with low vision. The efficacy of the detection of visual impairments in schoolers during preventive and distant computer screening was compared. In addition, significant indicators for visual impairment monitoring in schoolers were identified.
A "Program for the Prevention of the Development and Progression of Refractive Errors in Schoolchildren" was developed. To evaluate its efficacy, 140 pupils of general education schools with refractive errors and 1,302 pupils of gymnasiums with refractive er rors or their high risk underwent eye examinations. In addition, to compare the effect of wearing glasses/contact lenses with full correction on the quality of life, 31 schoolers aged 12β17 with refractive errors were selected.
Results: the rate of visual impairments was 28.4% among the pupils of general education schools and 31.3% among the pupils of gymnasiums. The most common refractive error was myopia (46.9% and 65.4%, respectively). As children moved through their school carrier, the proportion of myopia tended to increase. Accommodative dysfunction ranked second 48.5% and 29.7%, respectively). Time spent on distant screening was twice less compared to time spent on preventive screening. Visual acuity, cycloplegic refraction, reserves of relative accommodation, and axial length (measured by ultrasound) were indicators of visual impairments in children during monitoring. Poor general health was reported in 33% of children who wear glasses and 15% of children who wear contact lenses.
Keywords: refractive errors, myopia, accommodation, schoolchildren, distant screening, prevention, vision correction with contact lenses.
For citation: Botabekova T.K., Aldasheva N.A., Abdullina V.R. et al. Complex program for the prevention of the development and progression of refractive errors in school year children. Russian Journal of Clinical Ophthalmology. 2021;21(3):135β142 (in Russ.). DOI: 10.32364/2311-7729-2021-21-3-135-142.
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Physicochemical study of ammonium dicobalt(II)-octa-molybdenum with the composition (NH4)2[Co(H2O)4]2[Mo8O27]β’6H2O
Ammonium dicobalt(II)-octa-molybdenum with the composition (NH4)2[Co(H2O)4]2[Mo8O27]β’6H2O (I) is synthesized and studied by X-ray diffraction, IR spectroscopy, and thermogravimetry. The compound crystallizes in a triclinic system with the following unit cell parameters: a = 8.62923(9) Γ
, b = 9.4795(10) Γ
, c = 12.2071(13) Γ
, Ξ± = 104.326(2)Β°, Ξ² = 109.910(2)Β°, Ξ³ = 100.820(2)Β°, V = = 868.18(16) Γ
3, Ο(calc.) = 3.071 g/cm3, Z = 1. Space group is P-1. IR spectroscopic and thermogravimetric analyses are performed. Β© 2015 Pleiades Publishing, Ltd