MOLECULAR-GENETIC APPROACH FOR OPTIMIZATION OF MODERN ANTIAGGREGANT THERAPY

The targets of application of antiaggregant therapy by clopidogrel and the factors that influence its outcome were presented, in this review. Special attention was given to the application of personalized, approach for the optimization of clopidogrel therapy. The data of clinical investigations were discussed

First Measurements of Deuterium-Tritium and Deuterium-Deuterium Fusion Reaction Yields in Ignition-Scalable Direct-Drive Implosions

The deuterium-tritium (D-T) and deuterium-deuterium neutron yield ratio in cryogenic inertial confinement fusion (ICF) experiments is used to examine multifluid effects, traditionally not included in ICF modeling. This ratio has been measured for ignition-scalable direct-drive cryogenic DT implosions at the Omega Laser Facility [T. R. Boehly et al., Opt. Commun. 133, 495 (1997)] using a high-dynamic-range neutron time-of-flight spectrometer. The experimentally inferred yield ratio is consistent with both the calculated values of the nuclear reaction rates and the measured preshot target-fuel composition. These observations indicate that the physical mechanisms that have been proposed to alter the fuel composition, such as species separation of the hydrogen isotopes [D. T. Casey et al., Phys. Rev. Lett. 108, 075002 (2012)], are not significant during the period of peak neutron production in ignition-scalable cryogenic direct-drive DT implosions

Core conditions for alpha heating attained in direct-drive inertial confinement fusion

It is shown that direct-drive implosions on the OMEGA laser have achieved core conditions that would lead to significant alpha heating at incident energies available on the National Ignition Facility (NIF) scale. The extrapolation of the experimental results from OMEGA to NIF energy assumes only that the implosion hydrodynamic efficiency is unchanged at higher energies. This approach is independent of the uncertainties in the physical mechanism that degrade implosions on OMEGA, and relies solely on a volumetric scaling of the experimentally observed core conditions. It is estimated that the current best-performing OMEGA implosion [Regan et al., Phys. Rev. Lett. 117, 025001 (2016)10.1103/PhysRevLett.117.025001] extrapolated to a 1.9 MJ laser driver with the same illumination configuration and laser-target coupling would produce 125 kJ of fusion energy with similar levels of alpha heating observed in current highest performing indirect-drive NIF implosions.United States. Department of Energy (DE-FC02-04ER54789)United States. National Nuclear Security Administration (DE-NA0001944

Charity registration and reporting:a cross-Jurisdictional and theoretical analysis of regulatory impact

Increasingly governments worldwide regulate charities, seeking to restrict the number of organizations claiming taxation exemptions, reduce abuse of state support and fraud. Under public interest theory governments may increase philanthropy through public trust and confidence in charities. Under public choice theory regulators will maximize political returns, ‘manage’ charity-government relationships, and avoid regulatory capture. Phillips and Smith (2014) suggest that charities’ regulatory regimes should coalesce, despite jurisdictional diversity. We analyse charity regulatory regimes against underlining theories of regulation, and assess regulatory costs and benefits. Thus regulators can reduce regulatory inefficiency, and balance accountability and transparency demands with charities’ abilities to deliver

Indications of flow near maximum compression in layered deuterium-tritium implosions at the National Ignition Facility

An accurate understanding of burn dynamics in implosions of cryogenically layered deuterium (D) and tritium (T) filled capsules, obtained partly through precision diagnosis of these experiments, is essential for assessing the impediments to achieving ignition at the National Ignition Facility. We present measurements of neutrons from such implosions. The apparent ion temperatures T[subscript ion] are inferred from the variance of the primary neutron spectrum. Consistently higher DT than DD T[subscript ion] are observed and the difference is seen to increase with increasing apparent DT T[subscript ion]. The line-of-sight rms variations of both DD and DT T[subscript ion] are small, ∼ 150 eV, indicating an isotropic source. The DD neutron yields are consistently high relative to the DT neutron yields given the observed T[subscript ion]. Spatial and temporal variations of the DT temperature and density, DD-DT differential attenuation in the surrounding DT fuel, and fluid motion variations contribute to a DT T[subscript ion] greater than the DD T[subscript ion], but are in a one-dimensional model insufficient to explain the data. We hypothesize that in a three-dimensional interpretation, these effects combined could explain the results.Lawrence Livermore National Laboratory (Contract No. DE-AC52- 07NA27344

Laser writing of coherent colour centres in diamond

Optically active point defects in crystals have gained widespread attention as photonic systems that can find use in quantum information technologies [1,2]. However challenges remain in the placing of individual defects at desired locations, an essential element of device fabrication. Here we report the controlled generation of single nitrogen-vacancy (NV) centres in diamond using laser writing [3]. The use of aberration correction in the writing optics allows precise positioning of vacancies within the diamond crystal, and subsequent annealing produces single NV centres with up to 45% success probability, within about 200 nm of the desired position. Selected NV centres fabricated by this method display stable, coherent optical transitions at cryogenic temperatures, a pre-requisite for the creation of distributed quantum networks of solid-state qubits. The results illustrate the potential of laser writing as a new tool for defect engineering in quantum technologies

Confinement degradation and plasma loss induced by strong sawtooth crashes at W7-X

Sawtooth-like crashes were observed during electron cyclotron current drive experiments for strikeline controls at the optimised superconducting stellarator Wendelstein 7-X (W7-X). The majority of the crashes did not have a relevant impact on plasma performance. However, a limited number of events, characterised by a large plasma volume affected by the instability, have been related to a strong deterioration performance and even to the premature termination of the plasma. The hot plasma core expelled during these sawtooth crashes can reach the plasma edge, where plasma surface interaction can occur and impurities can be released. The x-ray tomography shows a strong radiation increase starting from the edge and moving towards the inner plasma regions. This results in the cooling down and shrinking of the plasma, which eventually leads to a poor coupling of the ECRH to the electrons, that can in turn result in a plasma loss. A relation between the size and amplitude of the sawtooth crashes and the impurity increase is reported.EC/H2020/633053/EU/Implementation of activities described in the Roadmap to Fusion during Horizon 2020 through a Joint programme of the members of the EUROfusion consortium/Eurato

Cryogneic-Target Performance and Implosion Physics Studies on OMEGA

Recent progress in direct-drive cryogenic implosions on the OMEGA Laser Facility [T. R. Boehly et al., Opt. Commun. 133, 495 (1997)] is reviewed. Ignition-relevant areal densities of ~200 mg/cm^2 in cryogenic D2 implosions with peak laser-drive intensities of ~5 x 10^14 W/cm^2 were previously reported [T. C. Sangster et al., Phys. Rev. Lett. 100, 185006 (2008)]. The laser intensity is increased to ~10^15 W/cm^2 to demonstrate ignition-relevant implosion velocities of 3–4 x 10^7 cm/ s, providing an understanding of the relevant target physics. Planar-target acceleration experiments show the importance of the nonlocal electron-thermal-transport effects for modeling the laser drive. Nonlocal and hot-electron preheat is observed to stabilize the Rayleigh–Taylor growth at a peak drive intensity of ~10^15 W/cm^2. The shell preheat caused by hot electrons generated by two-plasmon-decay instability was reduced by using Si-doped ablators. The measured compressibility of planar plastic targets driven with high-compression shaped pulses agrees well with one-dimensional simulations at these intensities. Shock mistiming has contributed to compression degradation of recent cryogenic implosions driven with continuous pulses. Multiple-picket (shock-wave) target designs make it possible for a more robust tuning of the shock-wave arrival times. Cryogenic implosions driven with double-picket pulses demonstrate somewhat improved compression performance at a peak drive intensity of ~10^15 W/cm^2