Semi-empirical model of middle atmosphere wind from the ground to the lower thermosphere

During recent years, special attention has been paid to understanding the background circulation of the middle atmosphere. Particularly in the mesosphere/lower thermosphere (MLT) region, this has involved including data from a range of new radar measurements. It has also involved the comparison of existing empirical middle atmosphere wind models, such as CIRA-86 and HWM-93 to the new data. This has led to the construction of empirical models of MLT winds such as the Global Empirical Wind Model (GEWM). Further investigations are aimed at the construction of new empirical and semi-empirical wind models of the entire middle atmosphere including these new experimental results. The results of a new wind climatology (0-100 km) are presented here, based upon the GEWM, a reanalysis of stratospheric data, and a numerical model which is used to fill the gap between data from the stratospheric and MLT regions. © 2008 COSPAR

Docking studies, cytotoxicity evaluation and interactions of binuclear copper(ii) complexes with s-isoalkyl derivatives of thiosalicylic acid with some relevant biomolecules

The numerous side effects of platinum based chemotherapy has led to the design of new therapeutics with platinum replaced by another transition metal. Here, we investigated the interactions of previously reported copper(II) complexes containing S-isoalkyl derivatives, the salicylic acid with guanosine-5′-monophosphate and calf thymus DNA (CT-DNA) and their antitumor effects, in a colon carcinoma model. All three copper(II) complexes exhibited an affinity for binding to CT-DNA, but there was no indication of intercalation or the displacement of ethidium bromide. Molecular docking studies revealed a significant affinity of the complexes for binding to the minor groove of B-form DNA, which coincided with DNA elongation, and a higher affinity for binding to Z-form DNA, supporting the hypothesis that the complex binding to CT-DNA induces a local transition from B-form to Z-form DNA. These complexes show a moderate, but selective cytotoxic effect toward colon cancer cells in vitro. Binuclear complex of copper(II) with S-isoamyl derivative of thiosalicylic acid showed the highest cytotoxic effect, arrested tumor cells in the G2/M phase of the cell cycle, and significantly reduced the expression of inflammatory molecules pro-IL-1β, TNF-α, ICAM-1, and VCAM-1 in the tissue of primary heterotopic murine colon cancer, which was accompanied by a significantly reduced tumor growth and metastases in the lung and liver

Трубка ендотрахеальна з системою для екстратубажного введення речовини

Трубка ендотрахеальна з системою для екстратубажного введення речовин, що включає інтубаційну трубку із конектором та герметизуючою манжетою, яка відрізняється тим, що лікарські засоби вводяться через канал в порожнину герметизуючої манжети, у стінках якої виконані перфоративні зрошуючі отвори діаметром 0,3 мм

Semi-empirical model of middle atmosphere wind from the ground to the lower thermosphere

During recent years, special attention has been paid to understanding the background circulation of the middle atmosphere. Particularly in the mesosphere/lower thermosphere (MLT) region, this has involved including data from a range of new radar measurements. It has also involved the comparison of existing empirical middle atmosphere wind models, such as CIRA-86 and HWM-93 to the new data. This has led to the construction of empirical models of MLT winds such as the Global Empirical Wind Model (GEWM). Further investigations are aimed at the construction of new empirical and semi-empirical wind models of the entire middle atmosphere including these new experimental results. The results of a new wind climatology (0-100 km) are presented here, based upon the GEWM, a reanalysis of stratospheric data, and a numerical model which is used to fill the gap between data from the stratospheric and MLT regions. © 2008 COSPAR

Semi-empirical model of middle atmosphere wind from the ground to the lower thermosphere

During recent years, special attention has been paid to understanding the background circulation of the middle atmosphere. Particularly in the mesosphere/lower thermosphere (MLT) region, this has involved including data from a range of new radar measurements. It has also involved the comparison of existing empirical middle atmosphere wind models, such as CIRA-86 and HWM-93 to the new data. This has led to the construction of empirical models of MLT winds such as the Global Empirical Wind Model (GEWM). Further investigations are aimed at the construction of new empirical and semi-empirical wind models of the entire middle atmosphere including these new experimental results. The results of a new wind climatology (0-100 km) are presented here, based upon the GEWM, a reanalysis of stratospheric data, and a numerical model which is used to fill the gap between data from the stratospheric and MLT regions. © 2008 COSPAR

Semi-empirical model of middle atmosphere wind from the ground to the lower thermosphere

During recent years, special attention has been paid to understanding the background circulation of the middle atmosphere. Particularly in the mesosphere/lower thermosphere (MLT) region, this has involved including data from a range of new radar measurements. It has also involved the comparison of existing empirical middle atmosphere wind models, such as CIRA-86 and HWM-93 to the new data. This has led to the construction of empirical models of MLT winds such as the Global Empirical Wind Model (GEWM). Further investigations are aimed at the construction of new empirical and semi-empirical wind models of the entire middle atmosphere including these new experimental results. The results of a new wind climatology (0-100 km) are presented here, based upon the GEWM, a reanalysis of stratospheric data, and a numerical model which is used to fill the gap between data from the stratospheric and MLT regions. © 2008 COSPAR