The influence of anxiety and depressive syndrome on the cognitive processes of patients with hypertension elderly and senile age

The article considers the influence of the presence of cognitive impairment on the severity of anxiety and depression in elderly and senile patients with stage 2 and 3 hypertension. According to the literature, it was known that cognitive impairment has a detrimental effect on the quality of life of patients, as well as the fact that patients with depression should carefully conduct a study of the cognitive sphere to choose the right treatment tactics.В статье рассмотрено влияние наличия когнитивных нарушений на выраженность тревоги и депрессии у пациентов пожилого и старческого возраста с гипертонической болезнью 2 и 3 стадии. Используя литературные данные, было выяснено, что когнитивные нарушения оказывают пагубное влияние на качество жизни пациентов, а также тот факт, что у пациентов с депрессией следует внимательно проводить исследование когнитивной сферы для выбора правильной лечебной тактик

Key intermediates in metallocene-and post-metallocene-catalyzed polymerization

The structures of intermediates formed upon the activation by methylaluminoxane (MAO) of a wide range of metallocene and post-metallocene catalysts of olefin polymerization were studied by C-13, H-1, and F-19 NMR. For all metallocenes considered (L2ZrCl2 and L2TiCl2), under conditions similar to real polymerization conditions (Al/Zr > 200), two types of intermediates were identified in the reaction solution, namely, heterodinuclear ion pairs [L-2 M(mu-Me)(2)AlMe2](+)[Me-MAO](-) (III) and zwitterionic intermediates L-2 MMe

Activation of rac-Me₂Si(ind)₂ZrCl₂ by methylalumoxane modified by aluminum alkyls : an EPR spin-probe, ¹H NMR, and polymerization study

Solutions containing mixtures of methylalumoxane (MAO) and iBu3Al give rise to 1H NMR signals indicative of the presence of the mixed alkyl aluminum dimers iBu2Al(µ-Me)2AliBu2 and of mixed clusters of the type (AlMe(1 + 2x − y)iBuyO(1 − x))n. These mixed clusters, as well as related species present in solutions containing either MAO–Et3Al or commercially available modified MAO (MMAO), appear to have stronger Lewis acidic sites and greater hydrodynamic radii than comparable clusters present in solutions of MAO alone, as judged from EPR signals observed in these solutions upon addition of TEMPO. When (SBI)ZrCl2 (SBI = rac-Me2Si(ind)2) is reacted with one of these mixed activator reagents, the mixed heterobinuclear cation [(SBI)Zr(µ-Me)2AlMeiBu]+ appears to be formed, together with its methyl counterpart [(SBI)Zr(µ-Me)2AlMe2]+, which is normally predominant in the (SBI)ZrCl2/MAO system at [Al]MAO/[Zr] ratios above 100. In the presence of iBu3Al, the formation of heterobinuclear cations is suppressed in favor of ion pairs containing the cation [(SBI)ZrMe]+ in contact with a (MAO–TIBA)-derived counter anion. The greater reactivity of these contact-ion pairs, as compared to the normally prevalent AlMe3 adducts, as well as an increased Lewis acidity of MMAO, and the ensuing decreased coordination ability of the [Me-(MAO–TIBA)]− counter ion as compared to [Me-MAO]−, are likely to contribute to the positive effects of TIBA additions on the co-catalytic activity of MAO