Theoretical and experimental investigation of the destruction of graphites in a flow of dissociated air

A method is presented for calculating the heating and erosion of blunt bodies made of graphite in a high-enthalpy flow of dissociated air, assuming chemical equilibrium on the surface and taking account of the thermal effects of combustion and sublimation of graphite. The analysis involves the use of a finite difference scheme to solve an equation of unsteady heat conduction. Attention is given to the equilibrium vaporization of C, C2 and C3 molecules. The calculations agree well with experimental data for a wide range of temperatures and stagnation pressures

Analysis of optical magnetoelectric effect in GaFeO_3

We study the optical absorption spectra in a polar ferrimagnet GaFeO_3. We consider the E1, E2 and M1 processes on Fe atoms. It is shown that the magnetoelectric effect on the absorption spectra arises from the E1-M1 interference process through the hybridization between the 4p and 3d states in the noncentrosymmetry environment of Fe atoms. We perform a microscopic calculation of the spectra on a cluster model of FeO_6 consisting of an octahedron of O atoms and an Fe atom displaced from the center with reasonable values for Coulomb interaction and hybridization. We obtain the magnetoelectric spectra, which depend on the direction of magnetization, as a function of photon energy in the optical region 1.0-2.5 eV, in agreement with the experiment.Comment: 18 pages, 5 figure

Effects of land use and climate changes on small reservoir siltation in the agricultural belt of European Russia

Small reservoirs of agriculture-dominated areas experience severely increased sediment input caused by soil erosion on cultivated slopes, also accompanied at some locations by gully erosion. This causes rapid decrease of the reservoir water storage and shortened periods of functioning. In this paper we discuss several examples of the 137Cs-based short-term siltation chronology of small reservoirs located in different landscape zones within the agricultural belt of European Russia. From two to four time marks could have been established in 137Cs depth distribution curves constructed from detailed depth-incremental sampling of reservoir infill sediment, allowing reconstruction of sediment microstratigraphy and deposition rates. In combination with other independent information sources this provides insight on the relative importance of recent land use changes and climatic variability in controlling sediment delivery within small agriculture-dominated fluvial systems. In combination with sediment redistribution studies, it has become possible to construct closed sediment budgets for catchments of several reservoirs and make a quantitative assessment of sediment delivery variability. Such information is important for appropriate design and management of small agricultural reservoirs in Russia. Copyright © 2013 IAHS Press

Using Chernobyl-derived 137Cs to document recent sediment deposition rates on the River Plava floodplain (Central European Russia)

Floodplain sedimentation is one of the most dynamic geomorphic processes within plain and lowland landscapes. There is generally a good understanding of longer term floodplain evolution, but quantitative information on overbank deposition rates for recent shorter timescales is lacking. This paper describes the application of Chernobyl-derived 137Cs to quantify floodplain aggradation rates for the River Plava (a small river draining a severely contaminated part of the upland region of Central European Russia), based on detailed sampling of four representative floodplain study sites. Two approaches have been employed for estimating post-Chernobyl (1986-2009) floodplain accumulation rates. The first was based simply on locating the Chernobyl fallout-associated 137Cs peak in overbank sediment sections. The second involved quantification of the increase in the total 137Cs inventory at individual sampling points associated with the post-Chernobyl deposition of contaminated suspended sediment. It has been shown that considerable local-scale variability of overbank deposition rates exists, with aggradation rates on the low level floodplain (6±1.2-14±2.8 mm year-1) exceeding by 1.5-3 times the values for the middle level floodplain (2±0.4-9±1.8 mm year-1) and by 3-6 times the values for the upper level floodplain (1±0.2-5±1.0 mm year-1) floodplain levels. Combining these estimates with information on the areas occupied by different floodplain levels within the 54 km long valley section, derived from detailed geomorphic surveys of the selected reaches, it has been estimated that about 9700±1950 t of sediment have been stored on floodplain during the 1986-2009 period. The role of floodplain storage in the overall basin sediment budget and conveyance losses within the main channel system have been evaluated. © 2012 John Wiley & Sons, Ltd

Antitumor features of Bacillus oligonitrophilus KU-1 strain

Chemotherapy and radiotherapy remain mostly palliative methods for metastatic cancer treatment. Limitations in efficacy and safety of established treatments continue to underline the need for improved treatments for malignancy. Results with some probiotics with antitumor activity have been promising. Here, we report that oral reception of Bacillus oligonitrophilus KU-1 resulted in the prolongation of lives in cancer patients with terminal prognosis and stabilization of cancer growth. The theoretical basis for the phenomena observed is discussed

Unexpected Temperature Behavior of Polyethylene Glycol Spacers in Copolymer Dendrimers in Chloroform

We have studied copolymer dendrimer structure: carbosilane dendrimers with terminal phenylbenzoatemesogenic groups attached by poly(ethylene) glycol (PEG) spacers. In this system PEG spacers areadditional tuning to usual copolymer structure: dendrimer with terminal mesogenic groups. Thedendrimer macromolecules were investigated in a dilute chloroform solution by 1H NMR methods(spectra and relaxations). It was found that the PEG layer in G = 5 generations dendrimer is “frozen”at high temperatures (above 260 K), but it unexpectedly becomes “unfrozen” at temperatures below250 K (i.e., melting when cooling). The transition between these two states occurs within a smalltemperature range (~10 K). Such a behavior is not observed for smaller dendrimer generations (G = 1and 3). This effect is likely related to the low critical solution temperature (LCST) of PEG and is caused bydendrimer conformations, in which the PEG group concentration in the layer increases with growing G.We suppose that the unusual behavior of PEG fragments in dendrimers will be interesting for practicalapplications such as nanocontainers or nanoreactors.</p

Role of PI3K/AKT/mTOR signaling pathway and sirtuin genes in chronic obstructive pulmonary disease development

Chronic obstructive pulmonary disease (COPD) is a multifactorial disease of the respiratory system which develops as a result of a complex interaction of genetic and environmental factors closely related to lifestyle. We aimed to assess the combined effect of the PI3K/AKT/mTOR signaling pathway (PIK3R1, AKT1, MTOR, PTEN) and sirtuin (SIRT1, SIRT3, SIRT6) genes to COPD risk. SNPs of SIRT1 (rs3758391, rs3818292), SIRT3 (rs3782116, rs536715), SIRT6 (rs107251), AKT1 (rs2494732), PIK3R1 (rs10515070, rs831125, rs3730089), MTOR (rs2295080, rs2536), PTEN (rs701848, rs2735343) genes were genotyped by real-time polymerase chain reaction (PCR) among 1245 case and control samples. Logistic regression was used to detect the association of SNPs in different models. Linear regression analyses were performed to estimate the relationship between SNPs and lung function parameters and smoking pack-years. Significant associations with COPD were identified for SIRT1 (rs3818292) (P = 0.001, OR = 1.51 for AG), SIRT3 (rs3782116) (P = 0.0055, OR = 0.69) and SIRT3 (rs536715) (P = 0.00001, OR = 0.50) under the dominant model, SIRT6 (rs107251) (P = 0.00001, OR = 0.55 for СT), PIK3R1: (rs10515070 (P = 0.0023, OR = 1.47 for AT), rs831125 (P = 0.00001, OR = 2.28 for AG), rs3730089 (P = 0.0007, OR = 1.73 for GG)), PTEN: (rs701848 (P = 0.0015, OR = 1.35 under the log-additive model), and rs2735343 (P = 0.0001, OR = 1.64 for GC)). A significant genotype-dependent variation of lung function parameters was observed for SIRT1 (rs3818292), SIRT3 (rs3782116), PIK3R1 (rs3730089), and MTOR (rs2536). Gene-gene combinations that remained significantly associated with COPD were obtained; the highest risk of COPD was conferred by a combination of G allele of the PIK3R1 (rs831125) gene and GG of SIRT3 (rs536715) (OR = 3.45). The obtained results of polygenic analysis indicate the interaction of genes encoding sirtuins SIRT3, SIRT2, SIRT6 and PI3KR1, PTEN, MTOR and confirm the functional relationship between sirtuins and the PI3K/AKT/mTOR signaling pathway

Electromagnetically induced magnetochiral anisotropy in a resonant medium

Chirality has been extensively studied for well over a century, and its potential applications range from optics to chemistry, medicine, and biology. Ingenious experiments have been designed to measure this naturally small effect. Here we discuss the possibility of producing a medium having a large chiral effect by using the ideas of coherent control. The coherent fields resonant with appropriate transitions in atomic or molecular systems can be used to manipulate the optical properties of a medium. We demonstrate experimentally very large magnetochiral anisotropy by using electromagnetic fields in atomic Rb vapors.Peer reviewedPhysic