117 research outputs found
ΠΠ»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½Π°Ρ Π³ΠΈΠΏΠ΅ΡΡΠ΅ΡΠΌΠΈΡ (ΡΠΈΠ½Π΄ΡΠΎΠΌ ΠΠΊΠ°ΡΠ°): Π½ΠΎΠ²ΡΠΉ Π²Π·Π³Π»ΡΠ΄ Π½Π° ΡΡΠ°ΡΡΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ
In the lecture shot history of research of etiology and pathogenesis of more dramatic complication of general anaesthesia β malignant hyperthermiaΒ - are presented. Importance of the interdisciplinary approach to working out of methods of preventive maintenance and treatment ofΒ it pharmacogenetics conditions in practice of the anaesthesiologist is underlined.Π Π»Π΅ΠΊΡΠΈΠΈ ΠΎΡΠ²Π΅ΡΠ΅Π½Π° ΠΊΡΠ°ΡΠΊΠ°Ρ ΠΈΡΡΠΎΡΠΈΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π²ΠΎΠΏΡΠΎΡΠΎΠ² ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π° ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈΠ· Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π΄ΡΠ°ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉΒ ΠΎΠ±ΡΠ΅ΠΉ Π°Π½Π΅ΡΡΠ΅Π·ΠΈΠΈ β Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΡΠ΅ΡΠΌΠΈΠΈ (ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° ΠΠΊΠ°ΡΠ°). ΠΠΎΠ΄ΡΠ΅ΡΠΊΠ½ΡΡΠ° Π²Π°ΠΆΠ½ΠΎΡΡΡ ΠΌΠ΅ΠΆΠ΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Π°ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π° ΠΊΒ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ΅ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΡΠΎΠ³ΠΎ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ Π² ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ Π½Π΅Π²ΡΠΎΠ»ΠΎΠ³Π° ΠΈ Π°Π½Π΅ΡΡΠ΅Π·ΠΈΠΎΠ»ΠΎΠ³Π°
ΠΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π³Π΅ΡΠ΅ΡΠΎΠ³Π΅Π½Π½ΠΎΡΡΡ Ρ ΠΎΠ½Π΄ΡΠΎΠ΄ΠΈΡΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠΈΠΎΡΠΎΠ½ΠΈΠΈ
Chondrodystrophic myotonia characterized by generalized myotonic myopathy, masklike face, skeletal dysplasia, contracture of joints,growth retardation and bone maturation delay. Two types have been defined by the age of manifestation of the symptoms: the severe neonatalΒ form, sometimes called type 2 (StuveβWiedemann syndrome), and the classical form (SchwartzβJampel syndrome) with late infantileΒ or childhood manifestation. Therapy targets electrical stabilization of the muscle membrane. Successful therapies include anticonvulsantsΒ and antiarrhythmic drugs.Π₯ΠΎΠ½Π΄ΡΠΎΠ΄ΠΈΡΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΌΠΈΠΎΡΠΎΠ½ΠΈΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ Π³Π΅Π½Π΅ΡΠ°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΌΠΈΠΎΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠΈΠΎΠΏΠ°ΡΠΈΠ΅ΠΉ, ΠΌΠ°ΡΠΊΠΎΠΎΠ±ΡΠ°Π·Π½ΡΠΌ Π»ΠΈΡΠΎΠΌ, ΡΠΊΠ΅Π»Π΅ΡΠ½ΠΎΠΉ Π΄ΠΈΡΠΏΠ»Π°Π·ΠΈΠ΅ΠΉ, ΠΊΠΎΠ½ΡΡΠ°ΠΊΡΡΡΠ°ΠΌΠΈ ΡΡΡΡΠ°Π²ΠΎΠ², Π·Π°Π΄Π΅ΡΠΆΠΊΠΎΠΉ ΡΠΎΡΡΠ° ΠΈ ΡΠΎΠ·ΡΠ΅Π²Π°Π½ΠΈΡ ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ. ΠΠ΄Π΅Π½ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½ΠΎ Π΄Π²Π° ΡΠΈΠΏΠ°Β Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ Π²ΠΎΠ·ΡΠ°ΡΡΠ° Π΄Π΅Π±ΡΡΠ°: ΡΡΠΆΠ΅Π»Π°Ρ Π½Π΅ΠΎΠ½Π°ΡΠ°Π»ΡΠ½Π°Ρ ΡΠΎΡΠΌΠ°, ΠΊΠΎΡΠΎΡΡΡ ΠΈΠ½ΠΎΠ³Π΄Π° Π½Π°Π·ΡΠ²Π°ΡΡ 2 ΡΠΈΠΏΠΎΠΌ (ΡΠΈΠ½Π΄ΡΠΎΠΌΒ Π‘ΡΡΠ²Π°βΠΠΈΠ΄Π΅ΠΌΠ°Π½Π½Π°), ΠΈ ΠΊΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠΎΡΠΌΠ° (ΡΠΈΠ½Π΄ΡΠΎΠΌ Π¨Π²Π°ΡΡΠ°βΠΠΆΠ°ΠΌΠΏΠ΅Π»Π°) Ρ Π΄Π΅Π±ΡΡΠΎΠΌ Π² ΠΌΠ»Π°Π΄Π΅Π½ΡΠ΅ΡΠΊΠΎΠΌ ΠΈΠ»ΠΈ Π΄Π΅ΡΡΠΊΠΎΠΌ Π²ΠΎΠ·ΡΠ°ΡΡΠ΅
ΠΠ΅Π½Π΅ΡΠΈΠΊΠ° ΡΠ΅ΠΌΠ΅ΠΉΠ½ΡΡ ΡΠΎΡΠΌ Π±ΠΎΠΊΠΎΠ²ΠΎΠ³ΠΎ Π°ΠΌΠΈΠΎΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΊΠ»Π΅ΡΠΎΠ·Π°
To analyze results of the studies covering modern scientific views on the genetics of familial amyotrophic lateral sclerosis (FALS).We searched for full-text publications containing the key words βamyotrophic lateral sclerosisβ, βFALSβ, and βgeneticsβ in the literature for the past 10 years in both Russian and English in eLibrary, PubMed, Web of Science, and OMIM databases. In addition, the review includes earlier publications of historical interest.This review summarizes all existing information on four most widespread genes associated with FALS: SOD1, TARDBP, FUS, and C9ORF72. The review also describes the functions of these genes and possible pathogenetic mechanisms of motor neuron death in amyotrophic lateral sclerosis (ALS), such as mitochondrial dysfunction, oxidative stress, glutamate excitotoxicity, damage to axonal transport components, and pathological neurofilament aggregation.As modern methods of molecular genetic diagnostics evolve, our knowledge about multifactorial FALS genetics expands. This information should be taken into consideration in clinical practice of neurologists. Information about the genes associated with ALS and understanding of particular pathogenetic mechanisms of the disease play a key role in the development of effective therapeutic strategies.ΠΠ½Π°Π»ΠΈΠ·ΠΈΡΡΡΡΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, ΠΎΡΡΠ°ΠΆΠ°ΡΡΠΈΡ
ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΠΎ Π³Π΅Π½Π΅ΡΠΈΠΊΠ΅ ΡΠ΅ΠΌΠ΅ΠΉΠ½ΡΡ
ΡΠΎΡΠΌ Π±ΠΎΠΊΠΎΠ²ΠΎΠ³ΠΎ Π°ΠΌΠΈΠΎΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΊΠ»Π΅ΡΠΎΠ·Π° (ΡΠΠΠ‘).ΠΡΠΎΠ²Π΅Π΄Π΅Π½ ΠΏΠΎΠΈΡΠΊ ΠΏΠΎΠ»Π½ΠΎΡΠ΅ΠΊΡΡΠΎΠ²ΡΡ
ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΉ Π½Π° ΡΡΡΡΠΊΠΎΠΌ ΠΈ Π°Π½Π³Π»ΠΈΠΉΡΠΊΠΎΠΌ ΡΠ·ΡΠΊΠ°Ρ
Π·Π° ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅Π΅ Π΄Π΅ΡΡΡΠΈΠ»Π΅ΡΠΈΠ΅ Π² Π±Π°Π·Π°Ρ
Π΄Π°Π½Π½ΡΡ
eLibrary, PubMed, Web of Science, OMIM, ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡ ΠΊΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π° Β«Π±ΠΎΠΊΠΎΠ²ΠΎΠΉ Π°ΠΌΠΈΠΎΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΊΠ»Π΅ΡΠΎΠ·Β» (ΠΠΠ‘), Β«ΡΠΠΠ‘Β», Β«Π³Π΅Π½Π΅ΡΠΈΠΊΠ°Β». ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, Π² ΠΎΠ±Π·ΠΎΡ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ Π±ΠΎΠ»Π΅Π΅ ΡΠ°Π½Π½ΠΈΠ΅ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΈ, ΠΈΠΌΠ΅ΡΡΠΈΠ΅ ΠΈΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ.ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅, Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½Π½ΡΠ΅ ΠΏΠΎ ΡΠ΅ΡΡΡΠ΅ΠΌ ΡΠ°ΠΌΡΠΌ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΡΠΌ Π³Π΅Π½Π°ΠΌ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΡΠΠΠ‘: SOD1, TARDBP, FUS ΠΈ C9ORF72. Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Π° ΡΡΠ½ΠΊΡΠΈΡ ΡΡΠΈΡ
Π³Π΅Π½ΠΎΠ², Π° ΡΠ°ΠΊΠΆΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΠ΅ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ Π³ΠΈΠ±Π΅Π»ΠΈ ΠΌΠΎΡΠΎΠ½Π΅ΠΉΡΠΎΠ½ΠΎΠ² ΠΏΡΠΈ ΠΠΠ‘: ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½Π°Ρ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΡ, Π³Π»ΡΡΠ°ΠΌΠ°ΡΠ½Π°Ρ ΡΠΊΡΠ°ΠΉΡΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡ, ΠΎΠΊΡΠΈΠ΄Π°ΡΠΈΠ²Π½ΡΠΉ ΡΡΡΠ΅ΡΡ, ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΡΠΈΡΡΠ΅ΠΌΡ Π°ΠΊΡΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ°, ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ Π°Π³ΡΠ΅Π³Π°ΡΠΈΡ Π½Π΅ΠΉΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠΎΠ².ΠΠΎ ΠΌΠ΅ΡΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΡΠ°ΡΡΠΈΡΡΡΡΡΡ Π·Π½Π°Π½ΠΈΡ Π² ΠΏΠΎΠ½ΠΈΠΌΠ°Π½ΠΈΠΈ Π³Π΅Π½Π΅ΡΠΈΠΊΠΈ ΡΠ΅ΠΌΠ΅ΠΉΠ½ΡΡ
ΠΌΡΠ»ΡΡΠΈΡΠ°ΠΊΡΠΎΡΠ½ΡΡ
ΡΠΎΡΠΌ ΠΠΠ‘, ΡΡΠΎ Π²Π°ΠΆΠ½ΠΎ ΡΡΠΈΡΡΠ²Π°ΡΡ Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ Π²ΡΠ°ΡΠ΅ΠΉ-Π½Π΅Π²ΡΠΎΠ»ΠΎΠ³ΠΎΠ². ΠΡΡΠ²Π»Π΅Π½ΠΈΠ΅ Π³Π΅Π½ΠΎΠ², ΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΡΡ
Π·Π° Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΠ΅ ΠΠΠ‘, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΠΎΠ½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΊΠΎΠ½ΠΊΡΠ΅ΡΠ½ΡΡ
ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΡΠ°Π·Π²ΠΈΡΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΈΠ³ΡΠ°ΡΡ ΠΊΠ»ΡΡΠ΅Π²ΡΡ ΡΠΎΠ»Ρ Π² ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΡΠ°ΡΠ΅Π³ΠΈΠΉ
THE ROLE OF INTERLEUKIN 1Ξ² GENE POLYMORPHISM IN DEVELOPMENT OF PREDOMINANTY SENSORY CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY
The aim of the present study was a search for associations between the polymorphic allelic variants 3954 C>T (rs1143644) and -511C>T (rs16944) of IL1B gene in the patients with sensory predominant chronic inflammatory demyelinating polyneuropathies (SP-CIDP) from Krasnoyarsk Region and the Sakha (Yakutia) Republic. A total of 95 people were examined, having been divided into 2 groups according to their residence. The first group consisted of 42 patients living in the Sakha (Yakutia) Republic. The second group included 53 patients living in the Krasnoyarsk Region. It was revealed that the carriers of homozygous CC genotype in the 3954C>T locus were more often detected in patients from the Sakha (Yakutia) Republic, and the carriage of TT genotype is found exclusively in the patients from Krasnoyarsk Region. When comparing the different genotype frequencies in the -511CT locus, we did not reveal any statistically significant differences between the two groups of patients. Presence of the CC genotype of the 3954C>T locus was associated with a significantly increased risk of disease in the patients from Sakha (Yakutia) Republic, while carrying CT and TT genotypes at the locus 3954C>T and the TT genotype at the locus -511C>T, is associated with increased risk disorder among patients of the Krasnoyarsk Region. The frequency of carriage of various genotypes in the 3954C>T and -511C>T loci of the IL1B gene was prevalent among the patients from the Sakha (Yakutia) Republic, the association of genotypes of CC/CT prevailed in patients from the Krasnoyarsk Region (p = 0.005), as well as prevalence of CC/CC and CC/CT (p = 0.023). However, there was no statistically significant difference in occurrence of individual genotypes between the two study groups. When analyzing the carrier frequency of high-producing alleles of 3954C and -511C in patients with SP-CIDP, it was shown that they were significantly more common among patients from the Sakha (Yakutia) Republic and patients from the Krasnoyarsk Region than the low-producing 3954T and -511T alleles. Moreover, the 3954C allele was more often found in the Yakut group (p = 0.001), and in the -511C allele for the Krasnoyarsk group of patients (p = 0.05). The presence of 3954C and -511C alleles increases the risk of SP-CIDP development in patients from the Sakha (Yakutia) Republic, as well as carriage of 3954T allele in patients from the Krasnoyarsk Region
Social adaptation and quality of life in reproductive-aged women with epilepsy
The quality-of-life indicators are integral characteristics of treatment and diagnostic measures in modern epileptology.Objective: to assess the social adaptation and quality of life in reproductive-aged women with epilepsy.Subjects and methods. A sociological survey using the Quality of Life Satisfaction questionnaire and the European Quality of Life-5 Dimensions (EQ-5D) was carried out in 352 women living in the Krasnoyarsk Territory.Results. At the time of the study, 21.3% of the patients were unemployed. Disability related to epilepsy was in 13.1% of women, mainly in those with cryptogenic (22.3%) and symptomatic (14.4%) epilepsy. Most of the women were unsatisfied with their job activity (55.1%), financial status (64.6%), and physical health (65.3%). Mainly the patients with symptomatic epilepsy reported dissatisfaction with their psychological status. The patients had employment problems (12.5%), inability to work in their specialty (12.5%) and to get the desired specialty (10.3%), and labor maladaptation (8.8%). There was a preponderance of women with higher education (40.3%) and 21.3% continued their studies. Warm family relations and help from relatives and friends (65.4%), hope for their recovery (50.7%), contacts with their friends (30.1%), and plans for future (34.6%) were important for the women to control the disease.Conclusions. The findings suggest that family, personal, maternity problems are more important causes of social maladaptation in epileptic women
Π€ΠΈΠ·ΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΡ Π±ΠΎΠ»Π΅Π·Π½ΠΈ Π¨Π°ΡΠΊΠΎβΠΠ°ΡΠΈβΠ’ΡΡΠ°
In the article there is a review the latest achievements in the field of physiotherapy CharcotβMarieβTooth disease (CMT). Describes someΒ of the techniques non-pharmacological treatment, the goal of physiotherapy application depending on the pathogenesis, clinical manifestationsΒ of the disease, electromiographic tests. Here there are recommendations for sanatoΒ¬rium treatment. On the basis of personal observationsΒ in the article presents the author's patterns of treatment for CMT patients.Π ΡΡΠ°ΡΡΠ΅ ΠΎΡΡΠ°ΠΆΠ΅Π½Ρ ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π΄ΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΡ Π² ΠΎΠ±Π»Π°ΡΡΠΈ ΡΠΈΠ·ΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π±ΠΎΠ»Π΅Π·Π½ΠΈ Π¨Π°ΡΠΊΠΎβΠΠ°ΡΠΈβΠ’ΡΡΠ° (Π¨ΠΠ’). ΠΠΏΠΈΡΠ°Π½Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈΒ ΡΠΈΠ·ΠΈΠΎΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ, ΡΠ΅Π»ΠΈ ΠΈΡ
ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π°, ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠΉ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, ΡΠ»Π΅ΠΊΡΡΠΎΠΌΠΈΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΠ°Π½Ρ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΏΠΎ ΡΠ°Π½Π°ΡΠΎΡΠ½ΠΎ-ΠΊΡΡΠΎΡΡΠ½ΠΎΠΌΡ Π»Π΅ΡΠ΅Π½ΠΈΡ. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ Π»ΠΈΡΠ½ΡΡ
Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠΉ Π²Β ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ Π°Π²ΡΠΎΡΡΠΊΠΈΠ΅ ΡΡ
Π΅ΠΌΡ ΡΠΈΠ·ΠΈΠΎΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π±ΠΎΠ»Π΅Π·Π½ΡΡ Π¨ΠΠ’
Herpesvirus-associated central and peripheral nervous system involvement: two clinical cases
Herpesviruses can directly affect the structure of the nervous system, resulting in encephalitis, and also induce immune-mediated disorders ofΒ the peripheral nervous system as sensory-predominant chronic inflammatory demyelinating polyneuropathy (CIDP). Patients with immunodeficiencyΒ may simultaneously develop two pathological processes, determining the severity of the condition. Parainfectious limbic encephalitisΒ (PILE) associated with viruses from the family Herpes viridae is a form of chronic herpes encephalitis, which is characterized by dysfunctionΒ of the limbic system and by a long-term course with exacerbations. CIDP is a dysimmune disease leasing to peripheral nervous system involvement,Β which belongs to a class of myelinopathies. The paper describes two clinical cases of a concurrence of chronic PILE and CIDP in middle-aged men who have symptomatic status epilepticus and iatrogenic complications. It characterizes difficulties in diagnosis and the clinicalΒ features of chronic herpes infection involving the central and peripheral nervous systems. The given clinical cases suggest that not only neurologistsand epileptologists, but also resuscitation specialists and ngiosurgeons should be particularly alert to the pathology in question
Problems of diagnostic management of congenital myotonia: to execute or to pardon
Congenital myotonia is a monogenetic disease, hereditary neuromuscular chanalopathy that affects skeletal muscles. Two types of myotonia congenita exist; autosomal dominant myotonia congenita also called Thomsen disease (OMIM160800), and recessive generalized myotonia (RGM) or Becker myotonia (OMIM 255700). Because several CLCN1 mutations can cause either Becker myotonia or Thomsen myotonia, doctors usually rely on characteristic signs and symptoms to distinguish the two forms of myotonia congenita. However, diagnostic errors are very common at the level of primary health care. The authors present a clinical case of late diagnosis of congenital myotonia (variant pseudo-Becker) in 42 years old man. Execution or to pardon the doctor who prescribed molecular diagnostic testing, which is not included in the approved standards?ΠΡΠΎΠΆΠ΄Π΅Π½Π½Π°Ρ ΠΌΠΈΠΎΡΠΎΠ½ΠΈΡ - ΠΌΠΎΠ½ΠΎΠ³Π΅Π½Π½ΠΎΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅, Π½Π°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½Π°Ρ ΠΊΠ°Π½Π°Π»ΠΎΠΏΠ°ΡΠΈΡ, ΠΏΡΠΈ ΠΊΠΎΡΠΎΡΠΎΠΉ ΠΏΠΎΡΠ°ΠΆΠ°ΡΡΡΡ ΡΠΊΠ΅Π»Π΅ΡΠ½ΡΠ΅ ΠΌΡΡΡΡ. ΠΡΠ΄Π΅Π»ΡΡΡ Π΄Π²Π° ΡΠΈΠΏΠ° Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΠΎΠΉ ΠΌΠΈΠΎΡΠΎΠ½ΠΈΠΈ: Π°ΡΡΠΎΡΠΎΠΌΠ½ΠΎ-Π΄ΠΎΠΌΠΈΠ½Π°Π½ΡΠ½ΡΡ Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΡΡ ΠΌΠΈΠΎΡΠΎΠ½ΠΈΡ, ΡΠ°ΠΊΠΆΠ΅ Π½Π°Π·ΡΠ²Π°Π΅ΠΌΡΡ ΠΌΠΈΠΎΡΠΎΠ½ΠΈΠ΅ΠΉ Π’ΠΎΠΌΡΠ΅Π½Π° (0Π1Π 160800), ΠΈ Π°ΡΡΠΎΡΠΎΠΌΠ½ΠΎ-ΡΠ΅ΡΠ΅ΡΡΠΈΠ²Π½ΡΡ Π³Π΅Π½Π΅ΡΠ°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½ΡΡ ΠΌΠΈΠΎΡΠΎΠ½ΠΈΡ (Π ΠΠ) ΠΈΠ»ΠΈ ΠΌΠΈΠΎΡΠΎΠ½ΠΈΡ ΠΠ΅ΠΊΠΊΠ΅ΡΠ° (0MIM 255700). ΠΠΎΡΠΊΠΎΠ»ΡΠΊΡ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΎ ΠΌΡΡΠ°ΡΠΈΠΉ Π³Π΅Π½Π° Ρ
Π»ΠΎΡΠ½ΠΎΠ³ΠΎ ΠΊΠ°Π½Π°Π»Π° CLCN1 ΠΌΠΎΠ³ΡΡ Π²ΡΠ·Π²Π°ΡΡ Π»ΠΈΠ±ΠΎ ΠΌΠΈΠΎΡΠΎΠ½ΠΈΡ Π’ΠΎΠΌΡΠ΅Π½Π°, Π»ΠΈΠ±ΠΎ ΠΌΠΈΠΎΡΠΎΠ½ΠΈΡ ΠΠ΅ΠΊΠΊΠ΅ΡΠ°, Π²ΡΠ°ΡΠΈ ΠΎΠ±ΡΡΠ½ΠΎ ΠΏΠΎΠ»Π°Π³Π°ΡΡΡΡ Π½Π° Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΡΠ΅ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ ΠΈ ΡΠΈΠΌΠΏΡΠΎΠΌΡ, ΡΡΠΎΠ±Ρ ΡΠ°Π·Π»ΠΈΡΠ°ΡΡ ΡΡΠΈ Π΄Π²Π΅ ΡΠΎΡΠΌΡ Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΠΎΠΉ ΠΌΠΈΠΎΡΠΎΠ½ΠΈΠΈ. ΠΠ΄Π½Π°ΠΊΠΎ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠΈΠ±ΠΊΠΈ ΠΎΡΠ΅Π½Ρ ΡΠ°ΡΡΡ Π½Π° ΡΡΠΎΠ²Π½Π΅ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠ³ΠΎ Π·Π²Π΅Π½Π° Π·Π΄ΡΠ°Π²ΠΎΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΡ. ΠΠ΄Π½ΠΎΠΉ ΠΈΠ· Π²Π΅Π΄ΡΡΠΈΡ
ΠΏΡΠΎΠ±Π»Π΅ΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½ΡΠ° Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΠΎΠΉ ΠΌΠΈΠΎΡΠΎΠ½ΠΈΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ Π½ΠΈΠ·ΠΊΠ°Ρ Π΄ΠΎΡΡΡΠΏΠ½ΠΎΡΡΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π΄Π»Ρ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ Π½Π°ΡΠ΅ΠΉ ΡΡΡΠ°Π½Ρ, ΠΏΠΎΡΠΎΠΌΡ ΡΡΠΎ ΡΡΠΎΡ Π²ΠΈΠ΄ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π½Π΅ Π²Ρ
ΠΎΠ΄ΠΈΡ Π² ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΡΡ
Π³Π°ΡΠ°Π½ΡΠΈΠΉ Π΄ΠΎ Π½Π°ΡΡΠΎΡΡΠ΅Π³ΠΎ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ. ΠΠ²ΡΠΎΡΠ°ΠΌΠΈ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠ»ΡΡΠ°ΠΉ ΠΏΠΎΠ·Π΄Π½Π΅ΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΠΎΠΉ ΠΌΠΈΠΎΡΠΎΠ½ΠΈΠΈ (Π²Π°ΡΠΈΠ°Π½Ρ ΠΏΡΠ΅Π²Π΄ΠΎ-ΠΠ΅ΠΊΠΊΠ΅ΡΠ°) Ρ 42-Π»Π΅ΡΠ½Π΅Π³ΠΎ ΠΌΡΠΆΡΠΈΠ½Ρ. ΠΠ°Π·Π½ΠΈΡΡ ΠΈΠ»ΠΈ ΠΏΠΎΠΌΠΈΠ»ΠΎΠ²Π°ΡΡ Π²ΡΠ°ΡΠ°, ΠΊΠΎΡΠΎΡΡΠΉ Π½Π°Π·Π½Π°ΡΠΈΠ» ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅, Π½Π΅ Π²Ρ
ΠΎΠ΄ΡΡΠ΅Π΅ Π² ΡΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π½ΡΠ΅ ΡΡΠ°Π½Π΄Π°ΡΡΡ
Π ΠΎΠ»Ρ ΡΡΡΠ΅ΠΉΡ-ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π² ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠΉ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ Ρ Π½Π°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΠΎΠΉ Π½Π΅Π²ΡΠΎΠΏΠ°ΡΠΈΠ΅ΠΉ Π¨Π°ΡΠΊΠΎβΠΠ°ΡΠΈβΠ’ΡΡΠ°
CharcotβMarieβTooth hereditary neuropathy (CharcotβMarieβTooth disease, CMT) is the most common form of hereditary neuropathies, accompanied by sensory disorders, progressive muscle weakness with the formation of disabling contractures of the limbs. Currently, the main treatment program is effective CMT habilitation, which can prevent the development of limb deformities and thereby improve the life quality of the patient. Stretch therapy is one of the most effective methods of prevention and treatment of contractures in patients with CMT. This article provides a brief review of the literature regarding the use of stretching as physical therapy program of CMT habilitation.ΠΠ°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½Π°Ρ Π½Π΅Π²ΡΠΎΠΏΠ°ΡΠΈΡ Π¨Π°ΡΠΊΠΎβΠΠ°ΡΠΈβΠ’ΡΡΠ° (Π±ΠΎΠ»Π΅Π·Π½Ρ Π¨Π°ΡΠΊΠΎβΠΠ°ΡΠΈβΠ’ΡΡΠ° ΠΠ¨ΠΠ’) β Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½Π°Ρ ΡΠΎΡΠΌΠ° Π½Π°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΡΡ
Π½Π΅Π²ΡΠΎΠΏΠ°ΡΠΈΠΉ, ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°ΡΡΠ°ΡΡΡ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΡΠΌΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΡΠΌΠΈ, ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΡΡΡΠ΅ΠΉ ΠΌΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠ»Π°Π±ΠΎΡΡΡΡ Ρ ΡΠΎΡ- ΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΈΠ½Π²Π°Π»ΠΈΠ΄ΠΈΠ·ΠΈΡΡΡΡΠΈΡ
ΠΊΠΎΠ½ΡΡΠ°ΠΊΡΡΡ ΠΊΠΎΠ½Π΅ΡΠ½ΠΎΡΡΠ΅ΠΉ. Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ ΠΌΠ΅ΡΠΎΠ΄ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΠ¨ΠΠ’ β ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ° ΡΡ- ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΠΈ, ΠΊΠΎΡΠΎΡΠ°Ρ ΠΌΠΎΠΆΠ΅Ρ ΠΏΡΠ΅Π΄ΠΎΡΠ²ΡΠ°ΡΠΈΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ Π΄Π΅ΡΠΎΡΠΌΠ°ΡΠΈΠΉ ΠΊΠΎΠ½Π΅ΡΠ½ΠΎΡΡΠ΅ΠΉ ΠΈ ΡΠ΅ΠΌ ΡΠ°ΠΌΡΠΌ ΡΠ»ΡΡΡΠΈΡΡ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ ΠΆΠΈΠ·Π½ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°. ΠΠ΄Π½ΠΈΠΌ ΠΈΠ· Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΊΠΎΠ½ΡΡΠ°ΠΊΡΡΡ ΠΏΡΠΈ ΠΠ¨ΠΠ’ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΡΠ΅ΠΉΡ-ΡΠ΅ΡΠ°ΠΏΠΈΡ. Π Π΄Π°Π½Π½ΠΎΠΉ ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ ΠΊΡΠ°ΡΠΊΠΈΠΉ ΠΎΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ Π² ΡΠ°ΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΡΡΠ΅ΠΉΡ-ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π² ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ΅ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΠΈ ΠΠ¨Π
Organization experience of diagnostic and medicosocial services for patients with CharcotβMarieβTooth disease in Krasnoyarsk region
Hereditary neuropathy Charcot-Marie-Tooth (CMT) is the most common form of hereditary polyneuropathies. Goal of the study was theΒ development of evidence-based diagnostic and treatment algorithms using patients with CMT (for example, in Krasnoyarsk Territory).Materials and methods: A total of 324 people. (probands and their relatives 1 and 2 lines of kinship). We analyzed 125 (38,5 %) clinicalΒ cases of CMT, 64/125 (51,2 %) clinical cases were include to statistical analysis (probands and their family trees, past the full rangeΒ of clinical and laboratory findings according to the protocol this study). Age ranged from 6 to 81 years, median age β 30,5 years, includingΒ women 24 (37,5 %), median age β 33,5 years; males 40 (62,5 %), median age β 28,5 years. Methods of diagnosis: clinical, genetic,Β neurophysiological, molecular genetic, assessment of quality of life assessment of anxiety and depression.Results: The family history of CMT noted in 53/57 (93,0 %) cases, with a predominance of autosomal dominant type of inheritance β52 (91,2 %) cases. As a result of DNA testing duplication of peripheral myelin protein gene (RMR22) on chromosome 17, held 34 survey,Β this mutation was found in 17 (50,0 %) patients. Modified method of computer esthesiometry for CMT diagnosis using domestic diagnosticΒ equipment βVibrotester-MBNβ BT-02-1 has a high sensitivity in the early stages of the disease and can be recommended for more widespreadΒ adoption of on par with other subjects of the Russian Federation
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