Synthesis and biological evaluation of some new 2,5-disubstituted 1,3,4-oxadiazoles from 3-(arylsulfonyl) propanehydrazides

208-211Methyl acrylate on treatment with aryl thiols gives methyl 3-(arylthio) propanoates. The latter on oxidation with hydrogen peroxide followed by reaction with hydrazine hydrate gives 3-(arylsulfonyl) propanehydrazides. Two new series of 2,5-disubstituted-1,3,4-oxadiazoles from 3-[(4-chlorophenyl)sulfonyl] propane hydrazide and 3-[(4-methylphenyl)-sulfonyl] propane hydrazide have been synthesized and tested for antimicrobial activities. Some of these compounds have shown good antimicrobial activity

Synthesis and characterisation of diastereomeric (<i style="">E</i> & <i style="">Z</i>) vinylsulfides and vinylsulfones from <i style="">p</i>-tolylphenylacetylene

765-769The addition of p-methylbenzenethiol to p-tolyl­phenyl­acetylene results in the formation of a mixture of diastereomeric (E) & (Z)-1-(4-methylphenyl)-2-phenyl-1-[(4-methyl­phenyl)thio] ethylenes (1 and 2) and (E) & (Z)-2-(4-methylphenyl)-1-phenyl-1-[(4-methylphenyl)thio] ethylenes (3 and 4). The configurations of these compounds have been established by 1H NMR studies, by their preparation from benzyl p-tolyl ketone and p-methylbenzyl phenyl ketone, and by the oxidation of the thioethylenes 1, 2, 3 and 4 to the corresponding sulfonylethylenes 5, 6, 7 and 8 respectively