1,022 research outputs found
Study of Apollo water impact. Volume 6 - User's manual - Interaction Final report
Computer program for hydroelastic responses of flexible shells of revolution during axially symmetric impact into incompressible fluids as in Apollo water impac
Study of Apollo water impact. Volume 3 - Dynamic response of shells of revolution during vertical impact into water - Hydroelastic interaction Final report
Hydroelastic response of spherical shell upon vertical water impac
Three-dimensional device fabrication in monocrystalline diamond using FIB and a novel lift-off technique
Low-temperature tapered-fiber probing of diamond NV ensembles coupled to GaP microcavities
In this work we present a platform for testing the device performance of a
cavity-emitter system, using an ensemble of emitters and a tapered optical
fiber. This method provides high-contrast spectra of the cavity modes,
selective detection of emitters coupled to the cavity, and an estimate of the
device performance in the single- emitter case. Using nitrogen-vacancy (NV)
centers in diamond and a GaP optical microcavity, we are able to tune the
cavity onto the NV resonance at 10 K, couple the cavity-coupled emission to a
tapered fiber, and measure the fiber-coupled NV spontaneous emission decay.
Theoretically we show that the fiber-coupled average Purcell factor is 2-3
times greater than that of free-space collection; although due to ensemble
averaging it is still a factor of 3 less than the Purcell factor of a single,
ideally placed center.Comment: 15 pages, 6 figure
Delayed presentation of an isolated gallbladder rupture following blunt abdominal trauma: a case report
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
Reactive direction control for a mobile robot: A locust-like control of escape direction emerges when a bilateral pair of model locust visual neurons are integrated
Locusts possess a bilateral pair of uniquely identifiable visual neurons that respond vigorously to
the image of an approaching object. These neurons are called the lobula giant movement
detectors (LGMDs). The locust LGMDs have been extensively studied and this has lead to the
development of an LGMD model for use as an artificial collision detector in robotic applications.
To date, robots have been equipped with only a single, central artificial LGMD sensor, and this
triggers a non-directional stop or rotation when a potentially colliding object is detected. Clearly,
for a robot to behave autonomously, it must react differently to stimuli approaching from
different directions. In this study, we implement a bilateral pair of LGMD models in Khepera
robots equipped with normal and panoramic cameras. We integrate the responses of these LGMD
models using methodologies inspired by research on escape direction control in cockroaches.
Using ‘randomised winner-take-all’ or ‘steering wheel’ algorithms for LGMD model integration,
the khepera robots could escape an approaching threat in real time and with a similar
distribution of escape directions as real locusts. We also found that by optimising these
algorithms, we could use them to integrate the left and right DCMD responses of real jumping
locusts offline and reproduce the actual escape directions that the locusts took in a particular
trial. Our results significantly advance the development of an artificial collision detection and
evasion system based on the locust LGMD by allowing it reactive control over robot behaviour.
The success of this approach may also indicate some important areas to be pursued in future
biological research
Causal propagation of geometrical fields in relativistic cosmology
We employ the extended 1+3 orthonormal frame formalism for fluid spacetime
geometries , which contains the Bianchi field
equations for the Weyl curvature, to derive a 44-D evolution system of
first-order symmetric hyperbolic form for a set of geometrically defined
dynamical field variables. Describing the matter source fields
phenomenologically in terms of a barotropic perfect fluid, the propagation
velocities (with respect to matter-comoving observers that Fermi-propagate
their spatial reference frames) of disturbances in the matter and the
gravitational field, represented as wavefronts by the characteristic 3-surfaces
of the system, are obtained. In particular, the Weyl curvature is found to
account for two (non-Lorentz-invariant) Coulomb-like characteristic eigenfields
propagating with and four transverse characteristic eigenfields
propagating with , which are well known, and four
(non-Lorentz-invariant) longitudinal characteristic eigenfields propagating
with |v| = \sfrac{1}{2}. The implications of this result are discussed in
some detail and a parallel is drawn to the propagation of irregularities in the
matter distribution. In a worked example, we specialise the equations to
cosmological models in locally rotationally symmetric class II and include the
constraints into the set of causally propagating dynamical variables.Comment: 25 pages, RevTeX (10pt), accepted for publication by Physical Review
The challenges faced in the design, conduct and analysis of surgical randomised controlled trials
Randomised evaluations of surgical interventions are rare; some interventions have been widely
adopted without rigorous evaluation. Unlike other medical areas, the randomised controlled trial
(RCT) design has not become the default study design for the evaluation of surgical interventions.
Surgical trials are difficult to successfully undertake and pose particular practical and methodological challenges. However, RCTs have played a role in the assessment of surgical innovations and there is scope and need for greater use. This article will consider the design, conduct and analysis of an RCT of a surgical intervention. The issues will be reviewed under three
headings: the timing of the evaluation, defining the research question and trial design issues.
Recommendations on the conduct of future surgical RCTs are made. Collaboration between
research and surgical communities is needed to address the distinct issues raised by the assessmentof surgical interventions and enable the conduct of appropriate and well-designed trials.The Health Services Research Unit is funded by the Scottish Government Health DirectoratesPeer reviewedPublisher PD
Methods to study splicing from high-throughput RNA Sequencing data
The development of novel high-throughput sequencing (HTS) methods for RNA
(RNA-Seq) has provided a very powerful mean to study splicing under multiple
conditions at unprecedented depth. However, the complexity of the information
to be analyzed has turned this into a challenging task. In the last few years,
a plethora of tools have been developed, allowing researchers to process
RNA-Seq data to study the expression of isoforms and splicing events, and their
relative changes under different conditions. We provide an overview of the
methods available to study splicing from short RNA-Seq data. We group the
methods according to the different questions they address: 1) Assignment of the
sequencing reads to their likely gene of origin. This is addressed by methods
that map reads to the genome and/or to the available gene annotations. 2)
Recovering the sequence of splicing events and isoforms. This is addressed by
transcript reconstruction and de novo assembly methods. 3) Quantification of
events and isoforms. Either after reconstructing transcripts or using an
annotation, many methods estimate the expression level or the relative usage of
isoforms and/or events. 4) Providing an isoform or event view of differential
splicing or expression. These include methods that compare relative
event/isoform abundance or isoform expression across two or more conditions. 5)
Visualizing splicing regulation. Various tools facilitate the visualization of
the RNA-Seq data in the context of alternative splicing. In this review, we do
not describe the specific mathematical models behind each method. Our aim is
rather to provide an overview that could serve as an entry point for users who
need to decide on a suitable tool for a specific analysis. We also attempt to
propose a classification of the tools according to the operations they do, to
facilitate the comparison and choice of methods.Comment: 31 pages, 1 figure, 9 tables. Small corrections adde
Motion Planning via Manifold Samples
We present a general and modular algorithmic framework for path planning of
robots. Our framework combines geometric methods for exact and complete
analysis of low-dimensional configuration spaces, together with practical,
considerably simpler sampling-based approaches that are appropriate for higher
dimensions. In order to facilitate the transfer of advanced geometric
algorithms into practical use, we suggest taking samples that are entire
low-dimensional manifolds of the configuration space that capture the
connectivity of the configuration space much better than isolated point
samples. Geometric algorithms for analysis of low-dimensional manifolds then
provide powerful primitive operations. The modular design of the framework
enables independent optimization of each modular component. Indeed, we have
developed, implemented and optimized a primitive operation for complete and
exact combinatorial analysis of a certain set of manifolds, using arrangements
of curves of rational functions and concepts of generic programming. This in
turn enabled us to implement our framework for the concrete case of a polygonal
robot translating and rotating amidst polygonal obstacles. We demonstrate that
the integration of several carefully engineered components leads to significant
speedup over the popular PRM sampling-based algorithm, which represents the
more simplistic approach that is prevalent in practice. We foresee possible
extensions of our framework to solving high-dimensional problems beyond motion
planning.Comment: 18 page
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