139 research outputs found
Protein carbonylation as a mechanism of regulation of MCF-7 breast cancer cell proliferation
Tumor progression is accompanied by dysregulation of cell proliferation and apoptosis, which plays an essential role in breast cancer pathogenesis and cell resistance to chemotherapy. The role of protein carbonylation in molecular mechanisms of regulating MCF-7 breast cancer cell proliferation under the effect of roscovitine, a selective inhibitor of cyclin-dependent kinases, was evaluated. The cells were grown in adherent cell culture with or without roscovitine. The levels of reduced/oxidized glutathione and the concentration of protein carbonyl derivatives were determined by spectrophotometry. The cell cycle was evaluated by the flow cytometry; the same technique was used to measure the reactive oxygen species (ROS) concentration. Cell culture with roscovitine resulted in a decrease in the redox potential of the glutathione system and a rise in the ROS and protein carbonyl derivative concentrations. Roscovitine contributed to the G0/G1 and G2/Π phase arrest due to its interaction with ATP-binding sites of cyclin-dependent kinases. Roscovitine could also promote enzyme carbonylation. The obtained results can be further used for development of personalized approaches to breast cancer therapy
ΠΠ½Π°Π»ΠΈΠ· ΡΠΎΠ²ΠΌΠ΅ΡΡΠ½ΠΎΠ³ΠΎ Π²Π»ΠΈΡΠ½ΠΈΡ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠ² Π³Π΅Π½ΠΎΠ² ΡΠΈΡΡΠ΅ΠΌΡ ΠΈΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½Π° OAS1, OAS3, PKR, IFNA17 ΠΈ IFNG Π½Π° ΠΏΡΠ΅Π΄ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΠΎΡΡΡ ΠΊ Ρ ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌΡ Π²ΠΈΡΡΡΠ½ΠΎΠΌΡ Π³Π΅ΠΏΠ°ΡΠΈΡΡ C
Interferon system plays a key role in the antiviral response. Based on data from the literature, the most dangerous for the development of infectious diseases is the combination of risk alleles of several genes. This study focuses on the analysis of the combined effect of single nucleotide polymorphisms of interferon system genes OAS1, OAS3, PKR, IFNA17 and IFNG in the predisposition to chronic viral hepatitis C. It has been shown that the accounting of several risk genes improves the prediction of development of this disease.Π‘ΠΈΡΡΠ΅ΠΌΠ° ΠΈΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½Π° ΠΈΠ³ΡΠ°Π΅Ρ ΠΊΠ»ΡΡΠ΅Π²ΡΡ ΡΠΎΠ»Ρ Π² ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ°. ΠΠ·Π²Π΅ΡΡΠ½ΠΎ, ΡΡΠΎ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΎΠΏΠ°ΡΠ½ΡΠΌ Π΄Π»Ρ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΡ
Π±ΠΎΠ»Π΅Π·Π½Π΅ΠΉ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ ΡΠΈΡΠΊΠΎΠ²ΡΡ
Π°Π»Π»Π΅Π»Π΅ΠΉ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΈΡ
Π³Π΅Π½ΠΎΠ².Π Π°Π±ΠΎΡΠ° ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° Π°Π½Π°Π»ΠΈΠ·Ρ ΡΠΎΠ²ΠΌΠ΅ΡΡΠ½ΠΎΠ³ΠΎ Π²Π»ΠΈΡΠ½ΠΈΡ ΠΎΠ΄Π½ΠΎΠ½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Π½ΡΡ
ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠ² Π³Π΅Π½ΠΎΠ² ΡΠΈΡΡΠ΅ΠΌΡ ΠΈΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½Π° OAS1, OAS3, PKR, IFNA17 ΠΈ IFNG Π½Π° ΠΏΡΠ΅Π΄ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΠΎΡΡΡ ΠΊ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌΡ Π²ΠΈΡΡΡΠ½ΠΎΠΌΡ Π³Π΅ΠΏΠ°ΡΠΈΡΡ Π‘. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΡΠ΅Ρ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΈΡ
ΡΠΈΡΠΊΠΎΠ²ΡΡ
Π³Π΅Π½ΠΎΠ² ΡΠ»ΡΡΡΠ°Π΅Ρ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ
ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ ΠΎΡΠ½ΠΎΠ²Ρ Π΄ΠΈΠ·ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π³ΠΈΠ±Π΅Π»ΠΈ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΠΏΡΠΈ Ρ ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ
The review analyses information from recent literature and results of the authorsβ own investigations concerning imbalance of programmed cell death in forming chronic viral infection. Molecular mechanisms of apoptosis modulation of immune cells by persistent viruses are discussed in the article.Π ΡΡΠ°ΡΡΠ΅ Π°Π½Π°Π»ΠΈΠ·ΠΈΡΡΡΡΡΡ Π΄Π°Π½Π½ΡΠ΅ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΎ ΡΠΎΠ»ΠΈ Π΄ΠΈΡΠ±Π°Π»Π°Π½ΡΠ° ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ Π³ΠΈΠ±Π΅Π»ΠΈ Π² ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ. ΠΠ±ΡΡΠΆΠ΄Π°ΡΡΡΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ ΠΌΠΎΠ΄ΡΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° ΠΈΠΌΠΌΡΠ½ΠΎΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΠ΅ΡΡΠΈΡΡΠΈΡΡΡΡΠΈΠΌΠΈ Π²ΠΈΡΡΡΠ°ΠΌΠΈ
Π€ΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΡ ΡΡΠΈΡΡΠΎΡΠΈΡΠΎΠ² Π½Π° ΡΡΠΎΠ²Π½Π΅ Π΄ΡΠ³ΠΈ Π°ΠΎΡΡΡ
The erythrocyte distribution at the level of aortic arch is determined experimentally from structural-functional features. It is shown that there exists the mechanism of physiological separation of erythrocytes, which causes the prevalent income of younger and functionally valid forms of erythrocytes to brain and favors better oxygen supply of nerve cells.ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΠΈΡΡΠΎΡΠΈΡΠΎΠ² Π½Π° ΡΡΠΎΠ²Π½Π΅ Π΄ΡΠ³ΠΈ Π°ΠΎΡΡΡ ΠΏΠΎ ΡΡΡΡΠΊΡΡΡΠ½ΠΎ-ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΌ ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ ΡΡΡΠ΅ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ° ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ ΡΡΠΈΡΡΠΎΡΠΈΡΠΎΠ², ΠΊΠΎΡΠΎΡΡΠΉ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»ΠΈΠ²Π°Π΅Ρ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ ΠΏΠΎΡΡΡΠΏΠ»Π΅Π½ΠΈΠ΅ Π±ΠΎΠ»Π΅Π΅ ΠΌΠΎΠ»ΠΎΠ΄ΡΡ
ΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎ ΠΏΠΎΠ»Π½ΠΎΡΠ΅Π½Π½ΡΡ
ΡΠΎΡΠΌ ΡΡΠΈΡΡΠΎΡΠΈΡΠΎΠ² Π² Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠΉ ΠΌΠΎΠ·Π³ ΠΈ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ ΡΠ»ΡΡΡΠ΅Π½ΠΈΡ ΡΠ½Π°Π±ΠΆΠ΅Π½ΠΈΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄ΠΎΠΌ Π½Π΅ΡΠ²Π½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ
ΠΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΠΏΡΠΈ ΠΊΠ»Π΅ΡΠ΅Π²ΠΎΠΌ ΡΠ½ΡΠ΅ΡΠ°Π»ΠΈΡΠ΅
Results of the complex research of apoptosis realization of lymphocytes at acute tick-born encephalitis and during long antigenemia condition has been presented in this article. The acceleration of apoptosis, tumor necrosis factor I presentation and the decrease in mitochondrial transmembrane potential of lymphocytes were determined at tick-born encephalitis. Uncovered changes are more appeared at acute neuroinfection.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΠΏΡΠΈ ΠΊΠ»Π΅ΡΠ΅Π²ΠΎΠΌ ΡΠ½ΡΠ΅ΡΠ°Π»ΠΈΡΠ΅ Π² ΠΎΡΡΡΡΠΉ ΠΏΠ΅ΡΠΈΠΎΠ΄, Π° ΡΠ°ΠΊΠΆΠ΅ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ Π°Π½ΡΠΈΠ³Π΅Π½Π΅ΠΌΠΈΠΈ Π²ΠΈΡΡΡΠ° ΠΊΠ»Π΅ΡΠ΅Π²ΠΎΠ³ΠΎ ΡΠ½ΡΠ΅ΡΠ°Π»ΠΈΡΠ°. ΠΡΠΈ ΠΊΠ»Π΅ΡΠ΅Π²ΠΎΠΌ ΡΠ½ΡΠ΅ΡΠ°Π»ΠΈΡΠ΅ ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° Π°ΠΏΠΎΠΏΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½Π½ΡΡ
Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ², ΠΊΠ»Π΅ΡΠΎΠΊ, Π½Π΅ΡΡΡΠΈΡ
Π½Π° ΡΠ²ΠΎΠ΅ΠΉ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡ ΠΊ ΡΠ°ΠΊΡΠΎΡΡ Π½Π΅ΠΊΡΠΎΠ·Π° ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ ΡΠΈΠΏΠ° I, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠΎ ΡΠ½ΠΈΠΆΠ΅Π½Π½ΡΠΌ ΡΡΠ°Π½ΡΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π½ΡΠΌ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠΉ. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½Π½ΡΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠ°ΠΆΠ΅Π½Ρ ΠΏΡΠΈ ΠΎΡΡΡΠΎΠΉ ΡΠΎΡΠΌΠ΅ Π½Π΅ΠΉΡΠΎΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ
Π ΠΎΠ»Ρ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° Π² Π΄ΠΈΡΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ Π»ΠΎΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ° ΠΏΡΠΈ Helicobacter pilory-ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ
The level of intracellular apoptosis regulators (cell death antagonists (Bcl-2) and agonists (CPP-32)), proliferation antigen Ki67 in lymphocytes of biopsy materials of the mucous coat of stomach at Helicobacter pylori-associated gastric ulcer and chronic gastritis in Khakassian aboriginal population and newcomers have been studied. The lymphocyte apoptosis in peripheral blood in aboriginal population was assessed. Changes in immunological indices were revealed in patients infected with Helicobacter pylori compared to healthy donors and newcomers. These changes were characterized by the more intense apoptotic lymphocyte death compared to the number of such cells in patients with chronic gastritis and in the control group. The role of apoptosis disfunctions in the regulation of local and system immunity at Helicobacter pylori infection is discussed.ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ ΡΡΠΎΠ²Π΅Π½Ρ Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠΎΠ² Π°ΠΏΠΎΠΏΡΠΎΠ·Π° β Π°Π½ΡΠ°Π³ΠΎΠ½ΠΈΡΡΠΎΠ² (Bcl-2) ΠΈ Π°Π³ΠΎΠ½ΠΈΡΡΠΎΠ² (CPP-32) ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ Π³ΠΈΠ±Π΅Π»ΠΈ, Π°Π½ΡΠΈΠ³Π΅Π½ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠΈ Ki-67 Π² Π»ΠΈΠΌΡΠΎΡΠΈΡΠ°Ρ
Π±ΠΈΠΎΠΏΡΠ°ΡΠΎΠ² ΡΠ»ΠΈΠ·ΠΈΡΡΠΎΠΉ ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΠΈ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° ΠΏΡΠΈ Helicobacter pyloriΠ°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠ·Π²Π΅Π½Π½ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΈ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌ Π³Π°ΡΡΡΠΈΡΠ΅ Ρ ΠΊΠΎΡΠ΅Π½Π½ΡΡ
ΠΈ ΠΏΡΠΈΡΠ»ΡΡ
ΠΆΠΈΡΠ΅Π»Π΅ΠΉ Π₯Π°ΠΊΠ°ΡΠΈΠΈ. ΠΡΠ΅Π½ΠΈΠ²Π°Π»ΡΡ Π°ΠΏΠΎΠΏΡΠΎΠ· Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ Ρ ΠΊΠΎΡΠ΅Π½Π½ΡΡ
ΠΆΠΈΡΠ΅Π»Π΅ΠΉ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Ρ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
, ΠΈΠ½ΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Helicobacter pylori, ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΡΠ°ΠΊΠΎΠ²ΡΠΌΠΈ Ρ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π΄ΠΎΠ½ΠΎΡΠΎΠ² ΠΈ ΠΏΡΠ΅Π΄ΡΡΠ°Π²ΠΈΡΠ΅Π»Π΅ΠΉ ΠΏΡΠΈΡΠ»ΠΎΠ³ΠΎ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ. ΠΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ, Π²ΡΡΠ²Π»Π΅Π½Π½ΡΠ΅ Π² ΠΊΡΠΎΠ²ΠΈ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ·Π²Π΅Π½Π½ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΡΡ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π»ΠΈΡΡ ΡΡΠΈΠ»Π΅Π½ΠΈΠ΅ΠΌ Π°ΠΏΠΎΠΏΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π³ΠΈΠ±Π΅Π»ΠΈ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎΠΌ ΡΠ°ΠΊΠΈΡ
ΠΊΠ»Π΅ΡΠΎΠΊ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌ Π³Π°ΡΡΡΠΈΡΠΎΠΌ ΠΈ Π² ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅. ΠΠ±ΡΡΠΆΠ΄Π°Π΅ΡΡΡ ΡΠΎΠ»Ρ Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° Π² ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ Π»ΠΎΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ° ΠΏΡΠΈ Helicobacter pylori-ΠΈΠ½ΡΠΈΡΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ
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