System and Method for Identification of Parkinson’s Disease Using Deep Neural Network

Parkinson’s illness may be a chronic sickness that affects several thousands of people. from the start, palladium patients feature not only with muscle rigidity and also with tremors. Most exams discover Parkinson’s illness by written tools, drawing like spirals as well as meanders on a paper. Later, analysists analyse the drawings and identify the illness. during this we tend to exploit machine learning technique, in this method machine can learn the data by examining digitalized version and written skills. we've associate interest in Convolutional Neural Networks has ability in learning options while not human interactio

Inhibitory effect of leaf and bark of Anacardium occidentale against clinical isolates of Staphylococcus aureus and Streptococcus mutans

The present study was undertaken to determine inhibitory activity of methanolic extract of leaf and bark of Anacardium occidentale L. (Anacardiaceae) against clinical isolates of Staphylococcus aureus and Streptococcus mutans recovered previously from burn and dental caries patients respectively. Agar well diffusion method was employed to investigate antibacterial activity. The extracts were found to be effective in inhibiting all clinical isolates. Leaf extract was found to inhibit bacteria to higher extent than bark extract. The inhibition of clinical isolates by the extracts could be ascribed to the presence of bioactive components present in the extracts.Â

Variation in adult life-history and stress resistance across five species of Drosophila

Dry weight at eclosion, adult lifespan, lifetime fecundity, lipid and carbohydrate content at eclosion, and starvation and desiccation resistance at eclosion were assayed on a long-term laboratory population of Drosophila melanogaster, and one recently wild-caught population each of four other species of Drosophila, two from themelanogaster and two from theimmigrans species group. The relationships among trait means across the five species did not conform to expectations based on correlations among these traits inferred from selection studies on D. melanogaster. In particular, the expected positive relationships between fecundity and size/lipid content, lipid content and starvation resistance, carbohydrate (glycogen) content and desiccation resistance, and the expected negative relationship between lifespan and fecundity were not observed. Most traits were strongly positively correlated between sexes across species, except for fractional lipid content and starvation resistance per microgram lipid. For most traits, there was evidence for significant sexual dimorphism but the degree of dimorphism did not vary across species except in the case of adult lifespan, starvation resistance per microgram lipid, and desiccation resistance per microgram carbohydrate. Overall,D. nasuta nasuta andD. sulfurigaster neonasuta (immigrans group) were heavier at eclosion than themelanogaster group species, and tended to have somewhat higher absolute lipid content and starvation resistance. Yet, these twoimmigrans group species were shorter-lived and had lower average daily fecundity than themelanogaster group species. The smallest species, D. malerkotliana (melanogaster group), had relatively high daily fecundity, intermediate lifespan and high fractional lipid content, especially in females. D. ananassae (melanogaster group) had the highest absolute and fractional carbohydrate content, but its desiccation resistance per microgram carbohydrate was the lowest among the five species. In terms of overall performance, the laboratory population of D. melanogaster was clearly superior, under laboratory conditions, to the other four species if adult lifespan, lifetime fecundity, average daily fecundity, and absolute starvation and desiccation resistance are considered. This finding is contrary to several recent reports of substantially higher adult lifespan and stress resistance in recently wild-caught flies, relative to flies maintained for a long time in discretegeneration laboratory cultures. Possible explanations for these apparent anomalies are discussed in the context of the differing selection pressures likely to be experienced by Drosophila populations in laboratory versus wild environments

ANTIOXDATIVE ACTIVITIES OF WILD MACRO FUNGI GANODERMA APPLANATUM (PERS.) PAT.

The present research work was under taken to evaluate antioxidant activity and quantitative determination of phytoconstituents of various solvent extracts of wild macro fungi Ganoderma applanatum (Pers.) Pat. using in vitro models. The total phenolic content was estimated using Folin-Ciocalteu method and total flavonoid content was determined using aluminum chloride. In vitro antioxidant activity of solvent extracts were studied in different systems including DPPH scavenging assay, reducing power assay, metal chelating activity, superoxide radical assay and hydrogen peroxide activity along with standard. The results revealed that, the total phenolics and flavonoids were high and extracts showed good antioxidant capacity in DPPH radical scavenging assay compared to other in vitro models. The methanol extract can be considered as a valuable source of antioxidant products as the obtained values are more or less near to the used standard compounds. The present study concludes that methanolic extract of study species is effective in scavenging free radicals and has the potential to be powerful antioxidant. This potent antioxidant activity may be attributed to its high phenolic and flavonoid content. Keywords: Antioxidant activity, Ganoderma applanatum, Radical scavenging, Phenolics, flavonoids

Blockchain-based Cloud Data Deduplication Scheme with Fair Incentives

With the rapid development of cloud computing, vast amounts of duplicated data are being uploaded to the cloud, wasting storage resources. Deduplication (dedup) is an efficient solution to save storage costs of cloud storage providers (CSPs) by storing only one copy of the uploaded data. However, cloud users do not benefit directly from dedup and may be reluctant to dedup their data. To motivate the cloud users towards dedup, CSPs offer incentives on storage fees. The problems with the existing dedup schemes are that they do not consider: (1) correctness - the incentive offered to a cloud user should be computed correctly without any prejudice. (2) fairness - the cloud user receives the file link and access rights of the uploaded data if and only if the CSP receives the storage fee. Meeting these requirements without a trusted party is non-trivial, and most of the existing dedup schemes do not apply. Another drawback is that most of the existing schemes emphasize incentives to cloud users but failed to provide a reliable incentive mechanism. As public Blockchain networks emulate the properties of trusted parties, in this paper, we propose a new Blockchain-based dedup scheme to meet the above requirements. In our scheme, a smart contract computes the incentives on storage fee, and the fairness rules are encoded into the smart contract for facilitating fair payments between the CSPs and cloud users. We prove the correctness and fairness of the proposed scheme. We also design a new incentive mechanism and show that the scheme is individually rational and incentive compatible. Furthermore, we conduct experiments by implementing the designed smart contract on Ethereum local Blockchain network and list the transactional and financial costs of interacting with the designed smart contract

Correlates of sexual dimorphism for dry weight and development time in five species of Drosophila

Pre-adult development time, dry weight at eclosion, and daily fecundity over the first 10 days of adult life were measured in five species of Drosophila from the melanogaster and immigrans species groups. Overall, the three species of the melanogaster group (D. melanogaster, D. ananassae, D. malerkotliana) developed faster, were lighter at eclosion, and produced more eggs per unit weight at eclosion than the two species of the immigrans group (D. n. nasuta, D. sulfurigaster neonasuta). The degree of sexual dimorphism in dry weight was greater than that in development time, but did not vary significantly among species, and was not correlated with fecundity, contrary to expectations that sexual selection for increased fecundity drives sexual size dimorphism in Drosophila. The degree of dimorphism in development time was significantly correlated with dry weight and fecundity, with lighter species tending to be more dimorphic for development time as well as more fecund, both in absolute terms and in terms of fecundity per unit weight. The results suggest that our understanding of the evolutionary forces maintaining sexual size dimorphism in Drosophila will probably benefit from more detailed studies on the correlates of sexual dimorphism within and among Drosophila species, and on the shape of reaction norms for the degree of sexual dimorphism across different levels of ecologically relevant environmental variables

Evolution of faster development does not lead to greater fluctuating asymmetry of sternopleural bristle number in Drosophila

Both strong directional selection and faster development are thought to destabilize development, giving rise to greater fluctuating asymmetry (FA), although there is no strong empirical evidence supporting this assertion. We compared FA in sternopleural bristle number in four populations ofDrosophila melanogaster successfully selected for faster development from egg to adult, and in four control populations. The fraction of perfectly symmetric individuals was higher in the selected populations, whereas the FA levels did not differ significantly between selected and control populations, clearly indicating that directional selection for faster development has not led to increased FA in sternopleural bristle number in these populations. This may be because: (i) development time and FA are uncorrelated, (ii) faster development does result in FA, but selection has favoured developmentally stable individuals that can develop fast and still be symmetrical, or (iii) the increased fraction of symmetric individuals in the selected populations is an artifact of reduced body size. Although we cannot discriminate among these explanations, our results suggest that the relationship between development time, FA and fitness may be far more subtle than often thought

Reduced larval feeding rate is a strong evolutionary correlate of rapid development in Drosophila melanogaster

This article does not have an abstract

STATISTICAL OPTIMIZATION AND EVALUATION OF ETHOSOMAL MICONAZOLE NITRATE SUSPENSION

Objective: The objectives of the present study were to optimize and evaluate the ethosomal suspension of miconazole nitrate for the treatment of local and systemic fungal infections. Methods: Miconazole topical formulation is prepared for better patient compliance and to reduce the dose of a drug. Miconazole nitrate ethosomes were prepared by the cold method using factorial designing with Ethanol(X1), IPA(Isopropyl alcohol)(X2), and Lecithin(X3) as Independent variables and % EE(Entrapment efficiency)(Y1) and % DR(drug release at 8th h)(Y2) was selected as responses. Results: The results obtained in the design showed that there was no significant interaction among factors. The lecithin concentration had a positive response on % EE, while ethanol concentration and IPA had a positive effect. For % DR, Ethanol, and IPA showed a positive effect and Lecithin had a negative response. The formulation EM22 (3 ml X1,3 ml X2 and 300 mg of X3) characterized by high % EE(77.3 %) and optimum % DR(94.2%) and formulation EM6 (2 ml X1,2 ml X2 and 100 mg of X3) characterized by high % DR(97.32 %) and optimum % EE (74.8 %). EM22 was incorporated in the gel as it is showing more entrapment efficiency and compared with the marketed product for drug release. Conclusion: From the result, it was concluded that formulated ethosomal suspension and optimized gel have more drug release than marketed formulation so that formulated suspension can be used for the preparation of antifungal gels, creams, ointments for sustained release

Correlated responses to selection for faster development and early reproduction in Drosophila: the evolution of larval traits

Studies on selection for faster development in Drosophila have typically focused on the trade-offs among development time, adult weight, and adult life span. Relatively less attention has been paid to the evolution of preadult life stages and behaviors in response to such selection. We have earlier reported that four laboratory populations of D. melanogaster selected for faster development and early reproduction, relative to control populations, showed considerably reduced preadult development time and survivorship, dry weight at eclosion, and larval growth rates. Here we study the larval phase of these populations in greater detail. We show here that the reduction in development time after about 50 generations of selection is due to reduced duration of the first and third larval instars and the pupal stage, whereas the duration of the second larval instar has not changed. About 90% of the preadult mortality in the selected populations is due to larval mortality. The third instar larvae, pupae, and freshly eclosed adults of the selected populations weigh significantly less than controls, and this difference appears during the third larval instar. Thereafter, percentage weight loss during the pupal stage does not differ between selected and control populations. The minimum amount of time a larva must feed to subsequently complete development is lower in the selected populations, which also exhibit a syndrome of reduced energy expenditure through reduction in larval feeding rate, larval digging and foraging activity, and pupation height. Comparison of these results with those observed earlier in populations selected for adaptation to larval crowding and faster development under a different protocol from ours reveal differences in the evolved traits that suggest that the responses to selection for faster development are greatly affected by the larval density at which selection acts and on details of the selection pressures acting on the timing of reproduction