PRIMARY MULTIDRUG RESISTANCE OF TUBERCULOSIS MYCOBACTERIUM ACCORDING TO DATA OF KRASNOYARSK REGIONAL TUBERCULOSIS DISPENSARY № 1 IN-PATIENT DEPARTMENT

This study of multidrug resistance (MDR) of tuberculosis mycobacterium. (TMB) frequency has revealed, that in 2011 28,4 % persons discharging bacteria with, newly diagnosed pulmonary tuberculosis had multidrug resistance of tuberculosis mycobacterium and among them are (70,1 %), rural population. (57,7 %), non-workers of employable age (56,7 %) prevailed. Among patients with, multidrug resistance (MDR) of tuberculosis mycobacterium. (TMB) there was a great propotion of patients with, disseminated tuberculosis (39,2 %), infiltrative tuberculosis (44,3 %), caseous pneumonia (7,2 %); there were 55,6 % of cases with profuse bacterioexcretin due to the violation of the Chest X-ray examination, terms. 45,3 % of patients with multidrug resistance also had. resistance to other essential antituberculosis drugs; in 54,7 % cases besides combination of this resistance there was also the rescue therapy drug resistance. Medical comment was made that under modern conditions it is not advisable to use chemotherapy of the first mode with patients with newly diagnosed pulmonary tuberculosis

PATHOMORPHISM OF INFILTRATIVE PULMONARY TUBERCULOSIS FOR A 20-YEAR PERIOD

Pattern of age, sex and social composition of newly diagnosed patients with infiltrative pulmonary tuberculosis was studied as well as characteristic features of the developed particular process and its clinical manifestations in three phases, covering a 20-year period, of observation (1989 - 105 patients, 2004 - 161 patients, 2009 - 399 patients). It was found that for 20 years infiltrative tuberculosis was subjected to significant pathomorphism which showed an increase in the proportion of cases among persons of older age groups and. women, an increasing role of exogenous superinfection and. concomitant diseases of the risk group in its pathogenesis, growth of damage at a constant rate of destruction and. bacterioexcretion. It is stated that in the dynamics there is an increase in frequency of primary drug resistance in tuberculosis Mycobacterium and. the loading of its structure. The features of clinical and. laboratory manifestations of infiltrative pulmonary tuberculosis are distinguished in modern conditions

MODERN CLINICOSOCIAL CHARACTERISTICS OF FIRST-REVEALED TUBERCULOSIS OF RESPIRATORY APPARATUS IN WOMEN OF TUVA REPUBLIC

We realized, the analysis of 134 cases of first-revealed tuberculosis of respiratory apparatus in women of Tuva Republic. We detected, prevalence of disseminate affections, high, frequency of dissociation, and bacterioexcre-tion (in 86,9 % of cases — excretion of drug-resistant bacteria, half of them, has plural drug resistance and. one third, has high, vitality, that proves high, epidemiologic risk of ill people). We marked, out factors of risk of tuberculosis morbidity in women and. determined, their significance in development of specific process. It was shown that disease in every fourth, woman is connected, with, pregnancy and. birth. We concluded, necessity of obligatory checking fluoroscopy for all women in puerperal period, during their stay in maternity hospital

EPIDEMIOLOGICAL ASPECTS OF THE TUBERCULOSIS PATHOMORPHISM IN MODERN CONDITIONS

Not only the growth of the death, rate and the morbidity rate can be considered as epidemiological manifestation. of the tuberculosis pathomorfism in modern conditions but also the changes of biological properties of the activator. Since 2003 till 2011 mycobacterium drug resistance with the patients with the newly diagnosed infiltrative tuberculosis which is of the most frequent occurrence has increased 1,4 times. The mycobacterium drug resistance has undergone the apparent qualitative changes. The percent of multidrug resistance has also increased. The combination of multidrug resistance and rescue therapy drug resistance has become more often. At the same time bacterioexcretin has become more profuse, mycobacterium growth rate has become slower and. the fact proves there is an interaction between two their biological properties - drug resistance and. growing power

TIMELY DETECTION OF PULMONARY TUBERCULOSIS AND INFLUENCING FACTORS

This study presents analysis of the timely detection of pulmonary tuberculosis in 1334 patients who underwent treatment in the Regional TB Dispensary N1 in Krasnoyarsk city in 2010-2011. Late detection of tuberculosis was established in 60,2 %, and factors which are contributing to it were as following: the male, living in rural areas, social vulnerability, and. violation of the regulated terms of X-ray examination. The significance of late diagnosed patients to increase the reservoir of tuberculosis infection and spread of drug-resistant strains among the population was shown. It was determined that an increase in coverage of population by preventive X-ray examinations resulted in improvement of quality indicators only in 2,6 % of active detection of pulmonary tuberculosis in the form of growing proportion of the patients revealed during preventive examinations timely, as well as reducing proportion of fibro-cavernous pulmonary tuberculosis and. post-mortem diagnosis of tuberculosis among the newly diagnosed patients. During the active detection of TB among population with a focus of work on real, established during the research, its groups the conclusion about the need to use the obtained results was made

CLINICAL COURSE OF HIV-ASSOCIATED TUBERCULOSIS IN THE PREGNANT WOMAN AND NEWBORN

The article describes the clinical case of TB/HIV coinfection in the pregnant woman and newborn. The discussion of the management tactics included main issues on which treatment success depended on: the right choice of chemotherapy regimen, correct decision on the time of delivery due to life-threatening conditions of the mother, timely diagnostics of tuberculosis in the newborn. It is necessary to develop cross-disciplinary guidelines by professional medical communities on the management of pregnant women with TB/HIV coinfection which will allow enhancing the quality of medical care to pregnant women and newborns at all stages of follow-up

KRASNOYARSK REGIONAL MORBID ANATOMY BUREAU

The article presents the clinical case of thyroid tuberculosis, diagnosed during thyroidectomy in the female patient suffering from nodular toxic goiter. Doctors are to be made aware about the rare localization of tuberculosis for its timely detection

Newly diagnosed respiratory organs tuberculosis with organized and unorganized population

The study purpose: comparative analysis of clinical cases structure, and to characterize the process with organized and unorganized population. The data under consideration concern newly diagnosed respiratory organs tuberculosis with in-patients at the age of 18 and older which were treated at the Krasnoyarsk Territory ТВ dispensary №1 in the years of 2007-2009.660 patients belonged to organized population and 1403 patients belonged to unorganized population. More severe structure of clinical cases and process characteristics with patients among unorganized population were determined. That was due to the fact that among them there were a great proportion of persons violating decreed terms of having their lungs X-rayed. Medical comment was made for managers of medical and preventive treatment institutions referring to public medical network. They should pay more attention to exercising control over maintenance of frequent X-ray lungs examination and following up not only patients from organized population who have been examined. But they also must take into account patients who have not been examined. And special attention must be paid to those from unorganized population because an epidemic danger which they constitute is two times greater than an epidemic danger which is constituted by organized population. Data resulting from the study may be used while planning of tuberculosis detection among different population categories.Цель работы: сравнительный анализ структуры клинических форм, характеристики процесса у организованного и неорганизованного населения. В разработку взяты данные о всех впервые выявленных больных туберкулезом легких в возрасте 18 лет и старше, проходивших стационарное лечение в Красноярском краевом противотуберкулезном диспансере №1 в 2007-2009 гг.: 660 больных - организованное население, 1403 - неорганизованное. Установлена более тяжелая структура клинических форм, характеристика процесса у заболевших из числа неорганизованного населения, что в значительной мере связано с доказанным большим удельным весом среди них лиц, нарушающих декретированные сроки флюорообследования (ПФЛГО). Сделано заключение о необходимости усиления контроля со стороны руководителей лечебно-профилактических учреждений общей лечебной сети за соблюдением регулярности прохождения ПФЛГО путем учета не только прошедших обследование, но и не прошедших его, особенно лицами из состава неорганизованного населения. Последнее приобретает особую важность ввиду их почти в 2 раза более высокой эпидемиологической опасности в случае развития заболевания. Полученные данные могут быть использованы при планировании и организации активного выявления туберкулеза среди различных категорий населения

Segmentation of microscopic images of sputum stained by Ziehl - Nielsen using wavelet transform Mexican Hat

Background. Currently at bacterioscopic diagnosis of tuberculosis there is a large number of errors that is associated with a number of problems that can be solved by automated analysis of microscopic images of sputum. Automated image analysis usually consists of several stages: image segmentation and identification or recognition of objects in the image. The article examines the first of these stages - segmentation. The aim of the study was to investigate the possibility of segmenting a digital image of a microscopic preparation sputum, stained by the method of Ziehl - Nielsen, using wavelet transform Mexican Hat. Materials and methods. As research material we used 830 digital images obtained by microscopy of sputum smears stained by the method of Ziehl - Nielsen. For the automated segmentation of images we used two-dimensional wavelet transform of Mexican Hat Wavelet. Results. During the study we defined the optimal value of the a parameter, which is the only varying parameter of a wavelet Mexican Hat, and carried out the run-time evaluation of the wavelet transform digital microscopic images of sputum stained by the method of Ziehl - Nielsen. Conclusions. The conclusion is made about possibility of using two-dimensional wavelet transform Mexican Hat digital microscopic images of sputum stained by the method of Ziehl - Nielsen, for segmentation of these images