30 research outputs found

    Transient quantum evolution of 2D electrons under photoexcitation of a deep center

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    We have considered the ballistic propagation of the 2D electron Wigner distribution, which is excited by an ultrashort optical pulse from a short-range impurity into the first quantized subband of a selectively-doped heterostructure with high mobility. Transient ionization of a deep local state into a continuum conduction c-band state is described. Since the quantum nature of the photoexcitation, the Wigner distribution over 2D plane appears to be an alternating-sign function. Due to a negative contribution to the Wigner function, the mean values (concentration, energy, and flow) demonstrate an oscillating transient evolution in contrast to the diffusive classical regime of propagation.Comment: 8 pages, 6 figures, pape

    MPTP-Treated Zebrafish Recapitulate ‘Late-Stage’ Parkinson’s-like Cognitive Decline

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    The zebrafish is a promising model species in biomedical research, including neurotoxicology and neuroactive drug screening. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) evokes degeneration of dopaminergic neurons and is commonly used to model Parkinson’s disease (PD) in laboratory animals, including zebrafish. However, cognitive phenotypes in MPTP-evoked experimental PD models remain poorly understood. Here, we established an LD50 (292 mg/kg) for intraperitoneal MPTP administration in adult zebrafish, and report impaired spatial working memory (poorer spontaneous alternation in the Y-maze) in a PD model utilizing fish treated with 200 µg of this agent. In addition to conventional behavioral analyses, we also employed artificial intelligence (AI)-based approaches to independently and without bias characterize MPTP effects on zebrafish behavior during the Y-maze test. These analyses yielded a distinct cluster for 200-µg MPTP (vs. other) groups, suggesting that high-dose MPTP produced distinct, computationally detectable patterns of zebrafish swimming. Collectively, these findings support MPTP treatment in adult zebrafish as a late-stage experimental PD model with overt cognitive phenotypes. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Funding: The experiments were implemented using the equipment and unique scientific installation “Biological collection–Genetic biomodels of neuropsychiatric disorders” (No. 493387) of the Federal State Budgetary Scientific Institution “Scientific Research Institute of Neurosciences and Medicine” theme no. AAAA-A21-121011990039-2 (2021–2025). The study partially used the facilities and equipment of the Resource Fund of Applied Genetics MIPT (support grant 075-15-2021-684)

    Recombination nearby N-n GaSb/GaInAsSb Staggered Lineup Heterojunction

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    The recombination nearby large band-offset staggered lineup N-GaSb/n-GaInAsSb heterojunction was investigated by means of the electroluminescence and carrier lifetime measurements. It was demonstrated that the nature of recombination, tuning rate as well as relation between radiative and non-radiative recombination strongly depend on the N-n band-offset and that its increase improves the carrier localization on the N-n interface

    Current and Temperature Tuning of Quantum-Well Lasers Operating in 2.0- to 2.4-µm Ranges

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    International audienceRadiation spectra of GaInAsSb/GaAlAsSb-based quantum-well diode lasers in pulsed and quasi-continuous operation modes were studied in the temperatures range from −10 to +20°C with driving currents varying from 50 to 200 mA. For currents exceeding the threshold value by no more than 30%, a single-mode lasing was usually observed. A further increase in current leads, as a rule, to the appearance of 3–5 additional long-wavelength cavity modes, which suggests the growth of gain in this spectral range due to the interaction of modes. In single-mode conditions, the lasing wavelength is red-shifted with temperature at a rate of 2–3 Å/K because of the current-induced heating of the laser and the corresponding increase in the refractive index. The rate of this heating is estimated at 0.1 µs
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