Core acid treatment influence on well reservoir properties in Kazan oil-gas condensate field

The research involves investigation of the influence of hydrochloric acid (HCI-12%) and mud acid ( mixture: HCl - 10 % and HF - 3 %) treatment on the Upper-Jurassic reservoir properties in Kazan oil-gas condensate field wells. The sample collection included three lots of core cylinders from one and the same depth (all in all 42). Two lots of core cylinders were distributed as following: first lot - reservoir properties were determined, and, then thin sections were cut off from cylinder faces; second lot- core cylinders were exposed to hydrochloric acid treatment, then, after flushing the reservoir properties were determined, and thin sections were prepared. Based on the quantitative petrographic rock analysis, involvin 42 thin sections, the following factors were determined: granulometric mineral composition, cement content, intergranular contacts and pore space structure. According to the comparative analysis of initial samples, the following was determined: content decrease of feldspar, clay and mica fragments, mica, clay and carbonate cement; increase of pore spaces while in the investigated samples- on exposure of rocks to acids effective porosity and permeability value range is ambiguous

Meteoprotective properties of melaxen in old and middle aged patients with ischemic heart disease in combination with arterial hypertension

We studied 102 patients (mean age 60.1±3.3 years) with arterial hypertension (AH) II-III stage, grade 2-3 and ischemic heart disease (exertional angina functional class (FC) I-II, postinfarction cardiosclerosis). The control group of patients received traditional therapy (TT): beta -blockers, calcium channel blockers, ACE inhibitors, antiplatelet agents, diuretics and nitrate

Polymorphism of genes associated with infectious lung diseases in Northern Asian populations and in patients with community-acquired pneumonia

The innate Iнн\mmune system is the first to respond to invading pathogens. It is responsible for invader recognition, immune-cell recruitment, adaptive-immunity activation, and regulation of inflammation intensity. Previously, two single-nucleotide polymorphisms of innate-immunity genes – rs5743708 (Arg753Gln) of the TLR2 gene and rs8177374 (Ser180Leu) of the TIRAP gene – have been shown to be associated with both pneumonia and tuberculosis in humans, but the data are contradictory among different ethnic groups. It has also been reported that rs10902158 at the PKP3-SIGGIR-TMEM16J genetic locus belongs to a haplotype race-specifically associated with tuberculosis. Meanwhile, a gradient of its frequency is observed in Asia. The aim of this work was to assess the effect of selection for the genotypes of the above-mentioned SNPs on the gene pools of populations living in harsh climatic conditions that contribute to the development of infectious lung diseases. We estimated the prevalence of these variants in white and Asian (Chukchis and Yakuts) population samples from Northern Asia and among patients with community-acquired pneumonia (CAP). Carriage of the rs5743708 A allele was found to predispose to severe CAP (odds ratio 2.77, p = 0.021), whereas the GG/CT genotype of rs5743708/rs8177374 proved to be protective against it (odds ratio 0.478, p = 0.022) in white patients. No association of rs10902158 with CAP (total or severe) was found among whites. Stratification of CAP by causative pathogen may help eliminate the current discrepancies between different studies. No significant difference in rs5743708 or rs8177374 was found between adolescent and long-lived white samples. Carriage of the alleles studied is probably not associated with predisposition to longevity among whites in Siberia. Both white and Asian populations studied were different from Western European and East Asian populations in the variants’ prevalence. The frequency of the rs8177374 T (Ser180Leu) variant was significantly higher in the Chukchi sample (p = 0, χ2 = 63.22) relative to the East Asian populations. This result may confirm the hypothesis about the selection of this allele in the course of human migration into areas with unfavorable climatic conditions

Cardiovascular system and musculoskeletal changes of the sportsmen with polymorphisms of col1a1 gene

Целью исследования явилось определение влияния полиморфизма гена COL1A1 на состояние сердечно-сосудистой системы и опорно-двигательного аппарата у спортсменов. Обследованы 85 спортсменов в возрасте от 9 до 32 лет (средний возраст составил 23,2±4,3), которые занимались игровыми и циклическими видами спорта. Изменения в опорно-двигательном аппарате у спортсменов определяли с помощью антропометрии и соматоскопии, для оценки кардиогемодинамических сдвигов применяли эходопплеркардиогрфическое обследование, полиморфизм гена COL1A1 определяли методом полимеразной цепной реакции. Результаты исследования полиморфизма rs1800012 гена COL1A1 показали значительную распространенность среди исследуемых спортсменов гетерозиготного варианта GT, который встречался с частотой 67,1%, при этом гомозиготный вариант гена – ТТ установлен в 3,5%. Фенотипически генотип ТТ полиморфизма rs1800012 гена COL1A1 проявлялся в долихостеномелии, гипермобильности суставов, увеличении частоты деформаций позвоночника и эластичности кожи, уменьшении толщины кожи и, как следствие, в увеличении общего показателя вовлечения соединительной ткани в диспластический процесс, что связано с нарушени ем качественного состава соединительнотканного каркаса. Функционально неблагоприятный генотип ТТ приводит к изменениям морфологии сердца и крупных сосудов и отклонениям в процессах релаксации миокарда.The purpose of the study of the study is an identification of the extension and impact of polymorphism of COL1A1 gene on cardiovascular system and musculoskeletal state of athletes. 85 people in the ages from 9 to 32 (the average age was 23.2±4.3 years) with polymorphisms rs 1800012 of COL1A1 gene were examined during this investigation. With the help of anthropometry and somatoscopy skeletal abnormalities were established. To cardiohemodynamic investigation was used echocardiography. Polymorphisms of COL1A1 gene analysis was done by polymerase chain reaction method. The study results of polymorphism of COL1A1gene rs 1800012 expansion pointed at the critical extension of heterozygous gene GT in the selected for analysis population however heterozygous gene TT is found only with frequency of 3.5%. Associated trait of genotype TT of polymorphisms of COL1A1gene rs 1800012 involves dolichostenomelia, joints’ hypermobility, frequency increase of back bone deflection and as a result rising CT exhaustion level in dysplastic process that is corresponded with abnormality of CT skeleton qualitative composition. Functionary unfavorable genotype TT leads to the changes in heart morphology, major vessels and myocardium relaxation process deflection

Knot homology via derived categories of coherent sheaves II, sl(m) case

Using derived categories of equivariant coherent sheaves we construct a knot homology theory which categorifies the quantum sl(m) knot polynomial. Our knot homology naturally satisfies the categorified MOY relations and is conjecturally isomorphic to Khovanov-Rozansky homology. Our construction is motivated by the geometric Satake correspondence and is related to Manolescu's by homological mirror symmetry.Comment: 51 pages, 9 figure

Detection of Five New RRATs at 111 MHz

Results of 111-MHz monitoring observations carried out on the Big Scanning Antenna of the Pushchino Radio Astronomy Observatory during September 1-28, 2015 are presented. Fifty-four pulsating sources were detected at declinations $-9^o < \delta < +42^o$. Forty-seven of these are known pulsars, five are new sources, and two are previously discovered transients. Estimates of the peak flux densities and dispersion measures are presented or all these sources.Comment: published in Astronomy Report, translated by Yandex translator with correction of scientific lexis, 8 pages, 2 figures, 3 table

Associations of changes in lipid metabolism parameters and the severity of COVID-19 infection in Novosibirsk residents

Aim. To study the associations of changes in lipid metabolism parameters and the severity of a coronavirus disease 2019 (COVID-19).Material and methods. This cross-sectional study included 270 patients aged 26-84 years (mean age, 53,09±13,22 years) who had COVID-19 within prior two months, which were divided into 3 groups: mild (1, n=128), moderate (2, n=128) and severe (3, n=14) COVID-19. Patients were assessed for body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), total cholesterol, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C). In addition, atherogenic index of plasma (AIP) was calculated. Statistical processing was performed using the SPSS software package (version 13.0).Results. Patients with severe COVID-19 had significantly higher levels of TG and AIP compared with patients with moderate and mild course. BMI and WC were significantly higher in patients in groups 2 and 3 compared with patients in group 1. In women, BMI and AIP levels were significantly higher in the severe COVID-19 group compared to groups 1 and 2. HDL-C levels were lower in patients with severe COVID-19 compared to those with moderate disease. WHR was higher among men in group 3 compared with group 1.Conclusion. Patients with severe COVID-19 have higher BMI, WC, AIP, TG levels, and lower HD-C levels. The relative odds for severe COVID-19 are associated with increased WC, AIP, TG, and lower HDL-C

Application of Basophil Activation Test with Anthraxin for Laboratory ( <I>in vitro</I>) Diagnostics of Anthrax

Demonstrated is the possibility to use in vitro basophil activation test with anthraxin, with registration of the results by means of flow cytometry, for anthrax diagnostics. This approach seems promising as it provides quantitative assessment of sensitization of the organism and does not cause its additional allergization. The duration of the analysis is 1h. The test is suggested for application, as an express one, for early and retrospective laboratory diagnostics of anthrax, estimation of post-vaccinal immunity

On Local Behavior of Holomorphic Functions Along Complex Submanifolds of C^N

In this paper we establish some general results on local behavior of holomorphic functions along complex submanifolds of \Co^{N}. As a corollary, we present multi-dimensional generalizations of an important result of Coman and Poletsky on Bernstein type inequalities on transcendental curves in \Co^{2}.Comment: minor changes in the formulation and the proof of Lemma 8.

Non-alcoholic fatty liver disease and metabolic liver dysfunction in the new coronavirus infection COVID-19

Our study aimed to explore associated non-alcoholic fatty liver disease (NAFLD) and metabolic liver dysfunction influence on the severity of the new coronavirus infection COVID-19. Material and methods. The study design was a cross-sectional study. The research included 215 patients (39.50 % of men) aged 26–60 years who had undergone a new coronavirus infection COVID-19 at least two months ago. Participants were divided into three groups by severity of infection: mild (n = 99), moderate and severe (n = 116) by anamnesis. Hepatic steatosis index (HIS), body mass index (BMI), waist circumference, alanine aminotransferase and gamma-glutamyl transpeptidase activity, glucose and triglyceride content, systolic and diastolic pressure were calculated and abdominal ultrasound examination was done. Results. In the group with moderate and severe course of COVID-19, the proportion of patients diagnosed with NAFLDaccording to the HSI index was significantly higher compared to patients with mild coronavirus infection. Patients with mild COVID-19, who were diagnosed with NAFLD, had higher alanine aminotransferase and gamma-glutamyl transpeptidase activity, glucose and triglyceride content, BMI, systolic and diastolic pressure, waist circumference compared to patients without NAFLD. Similar differences persisted for patients with moderate and severe course. With the step-by-step exclusion of cardiometabolic parameters from the logistic regression model, the triglyceride content and BMI retained association with steatohepatosis according to ultrasound data, regardless of severity. When creating a similar model for the HSI index, significant correlation was shown for alanine aminotransferase activity in patients with mild COVID-19, for alanine aminotransferase activity and BMI – in patients with moderate and severe COVID-19. Conclusions. Patients with NAFLD have a more severe course of COVID-19. In addition, associations of the severity of COVID-19 with a combination of NAFLD and other cardiometabolic changes in the body, such as arterial hypertension, obesity, dyslipidemia, were revealed