DIABETES MELLITUS TREATMENT: A RAPID REVIEW ON INNOVATIVE THERAPIES

Diabetes mellitus is a chronic and metabolic disorder which results from defects in a section of insulin, action of insulin, or both. Primarily drugs are used to control the symptoms and save life. Secondary aims are to prevent long-term diabetic complications and by eliminating various risk factors to increase longevity. In type I diabetes mellitus, new innovative therapies such as pancreatic transplantation, pancreatic islet transplantation, stem cell therapy, transdifferentiation, and gene therapy are discussed, and regarding type II diabetes mellitus, treatment is based on drugs which stimulates the secretion of insulin such as conventional therapy, antihypoglycemic agents such as insulin, insulin secretagogues, and insulin sensitizers, α-glucosidase inhibitors, dipeptidyl peptidase-4 inhibitors, and sodium-glucose cotransporter 2 inhibitors, and a list of patents for the treatment of diabetes mellitus are discussed in this review article

Understanding The Role Of Health Literacy In Self-Medication: Findings From A Cross-Sectional Study In West Godavari District Of Andhra Pradesh

Background: Self-medication is the practice of treating any ailment or symptom that a person diagnoses for themselves without first visiting a physician. Different communities display different behaviours; hence the purpose of this study is to statistically investigate the patterns and prevalence of self-medication usage. Although health literacy practices have been increasingly recommended in public health literature, there is a lack of studies that examine the relationships between health literacy and self-medication. Methodology: A quantitative, descriptive, cross-sectional, community-based research approach was used in a sample of 316 participants. Health literacy was measured by Single Item Literacy Screener. Data was analysed using SPSS 29.0 version. Results:  A total of 316 participants agreed to participate (63.9% were females). The results showed that more than half, 53.4% had adequate health literacy. The prevalence of self-medication was 74%, in these 52% had used medicines by previous prescription and 8% used alternative medicine. There was a significant relationship between the overall health literacy level and practice of self-medication. Conclusion: Improving the health literacy level of the public can reduce inappropriate self-medication Therefore, the design and implementation of training programs are necessary to increase the perception on the risk of self-medication. Appropriate reading skills are important for accessing health information, using health care services, and achieving desirable health outcomes

Analysis of Monosodium l-Glutamate in Food Products by High-Performance Thin Layer Chromatography

A simple, fast, specific, and precise high-performance thin layer chromatography method has been developed for the estimation of monosodium l-glutamate (MSG) in food products. Aluminum plates precoated with silica gel 60 GF254were used as stationary phase and a mixture of methanol–chloroform–formic acid in the ratio 5:5:1 (v/v) as mobile phase. Quantification was carried out by postchromatographic derivatization using 1% ninhydrin solution, and the developed spots were scanned by using a densitometer in absorbance mode at 485 nM. The Rfvalue of MSG was 0.64. The results of the analysis have been validated statistically and by the recovery studies. Linearity was observed in the concentration range of 400–1000 nG

Preparation and Characterisation of Crosslinked Natural Rubber (SMR CV 60) and Epoxidised Natural Rubber (ENR-50) Blends

In this sudy, the influenceof di(tert-butylperoxyisopropyl)benzene (DTBPIB) on the properties of natural rubber (NR) blend with epoxidized natural rubber (ENR) was determined. Fourier transform infrared spectroscopy with attenuated total refletance analysis and gel content confired crosslinking occurred in the rubber blends in the presence of peroxide DTBPIB percentage. Studies including tensile properties, dynamic mechanical properties, thermogravimetric analysis (TGA) and water absorptivity showed the changes in properties of the crosslinked NR/ENR blends. Tensile properties analysis disclosed the improvements in the modulus at 300% elongation and tensile stength with increasing NR ratios. Dynamic mechanical analysis revealed the blends to be incompatible and immiscible, with ENR showing a more viscous behaviour compared to the polymer blends. Thermal properties improved by blending NR with ENR as the onset temperature of NR/ENR: 50/50 was higher than pure NR by approximately 10oC and ENR by approximately 2oC. Water absorptivity experiment revealed a two-fold reduction in the presence of crosslinking for all blend ratios