An elusive case of acute abdomen in dengue fever

Currently dengue is endemic in all continents except Europe and epidemic dengue hemorrhagic fever occurs in Asia. Hemorrhagic manifestations observed at every stage of illness, they are probably the summation of ill understood virus as well as host factors that result in the incompetence of vescular endothelium

Rapid Spectrophotometric Determination of Ce(IV), As(III) & Nitrite with Promethazine Hydrochloride

763-76

Spectrophotometric Determination of Ru(III) with Promazine Hydrochloride

477-47

N-Substituted Phenothiazines as Reagents for the Spectrophotometric Determination of Traces of Au(III)

632-63

4-Bromo­methyl-7-methyl-6,8-dinitro­coumarin

The crystal structure of the title compound, C11H7BrN2O6, establishes the substitution positions of the nitro groups from the nitration reaction of 7-methyl-4-bromo­methyl coumarin. The mean planes of the nitro groups form dihedral angles of 43.9 (8) and 52.7 (10)° with the essentially planar [maximum deviation 0.031 (6) Å] benzopyran ring system

PRELIMINARY PHYTOCHEMICAL ANALYSIS AND IN VITRO ANTIOXIDANT ACTIVITY OF ARAUCARIA COLUMNARIS BARK PEEL AND COSMOS SULPHUREUS FLOWERS

Objective: Four different extracts of Araucaria columnaris (bark peel) and Cosmos sulphureus (flowers) were screened for their phytochemical composition, and free radical scavenging activities.Methods: DPPH method was used to test the antioxidant activity for extracts.Results: Among the different extracts tested, the methanol extract of both the plant species showed significant radical scavenging activities. Phytochemical analysis of the extracts revealed that the radical scavenging activities might be due to the presence of flavonoids, tannins and phenolic compounds.Conclusion: The results obtained suggest that Araucaria columnaris (bark peel) and Cosmos sulphureus(flowers) could be exploited in the treatment of various diseases like cancer, cardiovascular diseases and infection diseases. Â

Impact of socio demographic factors on the severity of maternal anaemia

Background: Anaemia in pregnancy is still a global problem and one of the leading causes for maternal mortality and morbidity in most of the developing countries. The aim and objective of the study was to know the role of various sociodemographic factors and its association with maternal anaemia.Methods: This is a retrospective observational study at a Community Health Centre in Chamarajanagar District. For the study purpose WHO categorization of severity of anaemia was used. All the delivered patients were divided into mild, moderate or severe degree of anaemia based on their hemoglobin (Hb%) levels at the time of delivery and the impact of the sociodemographic factors on the degree of anaemia was expressed as the percentage of severity.Results: A total of 1270 cases were included in the study out of which 270 (21.3%) of pregnant women had a normal hemoglobin level and 503 (39.6%) parturient were mildly anaemic, 460 (36.2%) with moderately anaemic and 2.9% (n=37) were severely anaemic. Patients who had an interpregnancy interval of >2 years, 60 % had normal Hb% and only 1.6% were severely anaemic. Moderate and severe anaemia was found more in women who were illiterates and an education level of less than high school level.Conclusions: Anaemia in pregnancy is associated with several social and demographic factors. Strategies must be taken from the conceptional level itself by providing proper antenatal counseling and women should be economically empowered and good antenatal care must be made available and accessible to all of them. Even with routine iron prophylaxis in pregnancy, still the prevalence of anaemia is high, so should we consider one or two doses of routine parenteral iron therapy for all pregnant women

Central cervical fibroid with a typical Lantern on top of St. Paul’s cathedral appearance

Leiomyoma of the uterus in one of the common benign gynecological conditions and one of the rare locations of a fibroid is from the cervix with an incidence of upto 2%. We are reporting a case of a 46 year old patient who came with complaints of mass per abdomen and with a history of retention of urine twice in the past one and half months. Abdominal examination revealed a firm mass of 24 weeks size gravid uterus with restricted mobility arising from the pelvis and a speculum examination, showed a mass protruding through the vagina with all the walls ballooned out and it appeared as if a head of the baby was protruding out in second stage of labor. It was a 1.9kg central cervical fibroid with a typical "Lantern on top of St. Paul’s cathedral" appearance which was operated without any complications

Dyeing of silk using Madhuca longifolia as natural dye source

The dried leaves of Madhuca longifolia has been evaluated for their potential as a source for natural dyeing of silk. Dye has been extracted under optimum conditions such as extraction pH (10), time (60 min) and temperature (95̊°C). The extracted dye has been applied on the silk fabrics and a range of shades are obtained using different methods with or without using mordants. It is found that mordants have a significant effect on the color of dyed silk fabrics. The dyed samples have been evaluated for color measurements and standard wash, light and rub fastness tests. The extracted dye is also tested for some of the eco-parameters using atomic absorption spectrophotometry and GC/MS. The test results are compared with set standards to determine the eco-friendliness of natural dye. Their concentrations are found to be lower than the stipulated limits. The dyed samples are also tested for antimicrobial activity against Gram-positive and Gram-negative bacteria. The dyed silk fabrics show acceptable fastness properties and are found to possess antibacterial activity. The results show that Madhuca longifolia leaves are promising as a natural colorant, which would, in turn, pave the way for the discovery of a new range of environment-friendly dyes for textile materials

FORMULATION OF IMMEDIATE RELEASE (IR) ATORVASTATIN CALCIUM PELLETS AND SUSTAINED RELEASE (SR) GLIBENCLAMIDE FOR FIXED-DOSE COMBINATION DOSAGE FORM

Objective: The objective of the present research was to develop fixed-dose combinations for the treatment of dyslipidemia, associated with type-II diabetes mellitus for improvement of glucose tolerance.Methods: Multiple unit pellet systems (MUPSs) consisting immediate release atorvastatin calcium pellets and sustained release glibenclamide were formulated by spheronization technique. The characterization of formulated pellets was done by Fourier transform infrared (FT-IR) and differential scanning calorimetry (DSC) studies, and formulated pellets were evaluated for solubility, viscosity, pH, and in vitro studies.Results: From FT-IR and DSC studies, it was confirmed that no chemical interaction existed between the drug and the natural polymers used. Solubility of glibenclamide was found to be 4.38 and 18.24 and atorvastatin calcium was found to be 6.84, 214.67, and 287.43 g/L. The viscosity of 1% w/v of locust bean gum, guar gum, and ghatti gum was found to be 169 cP, 124 cP, and 31 cP in distilled water. The pH of locust bean gum, guar gum, and gum ghatti solutions was found to be 5.6±0.49, 5.2±0.27, and 4.7±0.51. The in vitro studies suggested that glibenclamide pellets had shown a sustained release till 12 h, while atorvastatin calcium had shown immediate release of drug due to rapid disintegration of pellets.Conclusion: Thus, MUPS can be considered as an alternative approach to treat diabetes induced dyslipidemia