ROLE OF FETAL THIGH CIRCUMFERENCE IN ESTIMATION OF BIRTH WEIGHT BY ULTRASOUND

OBJECTIVE: To evaluate the accuracy and usefulness of predicting birth weight by measuring fetal thigh circumference by ultrasound. METHODS: In 110 pregnant women, fetuses without structural or chromosomal anomalies were studied prospectively and cross-sectionally. Thigh circumference (TC) was determined at the mid level of the thigh. Biparietal diameter (BPD), Head circumference (HC), Abdominal circumference (AC), and Femur length (FL) were measured using standard techniques. Fetal weights were estimated within a week prior to delivery. Statistical analysis of various ultrasound birth weight formulae in different weight categories was done and compared with each other and also with clinical methods. RESULTS: Estimated fetal birth weight using TC correlated well with actual birth weights in all categories and was superior to clinical and birth weight formulae using BPD, HC, AC and FL measurements. CONCLUSIONS: There was a good correlation between ultrasound measurement and actual postnatal measurements of thigh circumference (r2=0.89, p<0.01). Thigh circumference measurement was simple and there was better accuracy when it was combined along with BPD, HC, AC and FL measurements

An unusual case of Foetal Gastroschisis with Limb aplasia and Extra-corporal liver

Gastroschisis represents a herniation of abdominal contents through a paramedian full-thickness abdominal fusion defect without involving the umbilical cord. Evisceration usually only contains intestinal loops and has no surrounding membrane unlike in ophalocoele. It is unusual for a newborn born with gastroschisis to have other serious birth defects and neonates have better prognosis than those with an omphalocele. Very rarely gastroschisis is associated with herniation of major viscus and their presence makes the prognosis worst. This case is reported because of its rare association with extra-corporal liver and limb aplasia

Subjectivities of Suitability: ‘Intimate Aspirations’ in an Engineering College

In this paper, I attempt to capture the “intimate aspirations” of young women as they emerge in the narratives of their relationships in college, their marriage strategies and negotiations in an engineering college in Tamil Nadu. Given the kind of surveillance and the disciplinary mechanisms implemented by college authorities, the engineering college is not just a site of youth sociality, but emerges in politically significant ways to influence students’ “intimate aspirations.” Relationship trajectories develop on a terrain of intersectionality between caste and gender as students explore possible marriage through the possibility of being able to “convince” parents. While potentially indicating shifts in endogamy, what these “choices” conclusively show is the crafting of suitable subjectivities within the realm of the acceptable. Young women emphasize their professional and academic achievements, and those of their partners, in ways that complement existing status, in order to highlight a suitable marriage. I argue that such responses show the concomitant ways in which caste and gender are produced

Assessment of awareness on generic drugs among health care professionals and laypersons

Background: In the present day world the expenditure on medicines is very high. Most of the people in developing countries find it difficult to afford expensive medicines. One of the measures to cut down the expenditure on medicines is to use generic drugs. Hence the study was taken up to know the awareness, attitude and preference for generic drugs among medical and non medical persons.Methods: The study was done on 290 participants. 60 medical interns, 30 doctors, 50 nurses, 50 non medical staff (clerks and attenders) and 100 patients were included. They were given a questionnaire to know the awareness and knowledge on generic drugs, willingness to prescribe (among doctors) and use it (non medical staff and patients).Results: This study showed that all medical persons- doctors, interns and nurses knew about generic drugs whereas 60% of non medical staff and 95% of the patients were not aware about it. All doctors had good knowledge about generic drugs and 80% prescribed it always. 70% of the patients depended on what doctors prescribed for them and never asked for generic/ branded drugs in particular. 70% non medical staff preferred it only sometimes.Conclusions: The awareness among non medical persons is poor than medical persons among the surveyed population. Hence adequate measures should be taken to increase awareness and knowledge among public so that they become imperative enough to ask their doctors to prescribe generic drugs

Impact of educational intervention on pressurized metered dose inhaler technique among undergraduate medical students

Background: Inhaled medications form the cornerstone for the management of Asthma and related diseases. Proper technique of pressurized metered dose Inhalers (pMDIs) has proven to be associated with higher level of control of these conditions. Medical personnel who are responsible for training patients must themselves be proficient with usage of pMDI. This study evaluated the outcome of different educational interventions regarding the correct usage of pMDI.Methods: An interventional study was carried out with 60 second year medical students in department of pharmacology, HIMS, Hassan from June to August 2015. Pre and post intervention (after one week and one month) was evaluated based on National Asthma Education and Prevention Program (NAEPP) criteria for the use of pMDI by written and demonstration methods. The interventions included a video clip, an information leaflet and demonstration by a trained faculty.Results: Overall mean scores in pre-test for written knowledge and skill demonstration are 2.13±1.49 and 3.78±1.06 .There was substantial improvement in post intervention scores 7.15±1.41 and 7.37±1.67 (p<0.05) . Using one way ANOVA, demonstration group has shown statistically significant improvement in mean score compared to video and checklist groups in 1 week (8.8 versus 7.2 and 6.1, p<0.05) and 1 month (8.25 versus 7.1 and 5.7 (p<0.05) after the intervention.Conclusions: Correct usage of pMDI is a necessary skill for health care professionals and can be taught by various methods. The educational intervention by an interactive demonstration has proven to be effective in learning the inhaler technique

A prospective evaluation of efficacy and safety of topical bromfenac 0.09% over topical flurbiprofen 0.03% after cataract surgery

Background: Different medications are used to reduce pain and inflammation after cataract surgery. Hence this study was taken up to compare the efficacy and safety of topical bromfenac 0.09% over topical flurbiprofen 0.03% in reducing anterior chamber inflammation and pain after cataract surgery.Methods: Total of 100 patients who underwent uneventful cataract surgery with posterior chamber intra ocular lens (IOL) implantation were randomly allocated to receive bromfenac 0.09% and flurbiprofen 0.03% topically from first post-operative day onwards for 6 weeks. Assessment of anterior chamber inflammation and pain was done by slit lamp and visual analogue scale respectively on each follow up days. Analysis was done by unpaired t test and Fischer’s exact test.Results: The response to treatment was earlier in bromfenac group for all the inflammatory changes (significant difference was found on day 7, p<0.05) except for corneal edema where both the groups showed similar response. On 7th day after surgery, 72% patients in flurbiprofen group and 12% in bromfenac group had pain (score1), while on the 14th day none in the bromfenac group complained of pain whereas 4% in flurbiprofen group still had pain. Both the drugs were safe and no clinically serious adverse effects were observed in either of the groups.Conclusions: This study showed both the medications, topical bromfenac 0.09% and topical flurbiprofen 0.03% effective and safe in reducing pain and anterior chamber inflammation after cataract surgery but the response was earlier with bromfenac 0.09%

Beyond numbers, coverage and cost : adaptive governance for post-COVID-19 reforms in India

Crisis as an opportunity for change has been part of historical and development literature and is an oft-repeated theme. The Chinese word for crisis (危機), for example, consists of two symbols often characterised in popular literature as denoting ‘danger’ and ‘opportunity’.1 For India’s healthcare system, the COVID-19 crisis has highlighted the urgency of reform. We have learnt that no matter how long or how stringent a lockdown is, we cannot flatten the curve effectively, nor fairly, without a robust health system. In the pre-COVID-19 world, practitioners and policy-makers were gathering around the Universal Health Coverage (UHC) agenda that sought to expand the number of health services provided to the largest number of beneficiaries at the cheapest possible cost, constituting the three dimensions of UHC.2 This pandemic has made it clear that incremental progress along those three dimensions while necessary, is insufficient to move towards a health system that is responsive, resilient and fai

Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study

We aimed to characterize metabolites during tuberculosis (TB) disease and identify new pathophysiologic pathways involved in infection as well as biomarkers of TB onset, progression and resolution. Such data may inform development of new anti-tuberculosis drugs. Plasma samples from adults with newly diagnosed pulmonary TB disease and their matched, asymptomatic, sputum culture-negative household contacts were analyzed using liquid chromatography high-resolution mass spectrometry (LC-MS) to identify metabolites. Statistical and bioinformatics methods were used to select accurate mass/charge (m/z) ions that were significantly different between the two groups at a false discovery rate (FDR) of q<0.05. Two-way hierarchical cluster analysis (HCA) was used to identify clusters of ions contributing to separation of cases and controls, and metabolomics databases were used to match these ions to known metabolites. Identity of specific D-series resolvins, glutamate and Mycobacterium tuberculosis (Mtb)-derived trehalose-6-mycolate was confirmed using LC-MS/MS analysis. Over 23,000 metabolites were detected in untargeted metabolomic analysis and 61 metabolites were significantly different between the two groups. HCA revealed 8 metabolite clusters containing metabolites largely upregulated in patients with TB disease, including anti-TB drugs, glutamate, choline derivatives, Mycobacterium tuberculosis-derived cell wall glycolipids (trehalose-6-mycolate and phosphatidylinositol) and pro-resolving lipid mediators of inflammation, known to stimulate resolution, efferocytosis and microbial killing. The resolvins were confirmed to be RvD1, aspirin-triggered RvD1, and RvD2. This study shows that high-resolution metabolomic analysis can differentiate patients with active TB disease from their asymptomatic household contacts. Specific metabolites upregulated in the plasma of patients with active TB disease, including Mtb-derived glycolipids and resolvins, have potential as biomarkers and may reveal pathways involved in TB disease pathogenesis and resolution

Physical properties of tender coconut

Not AvailableThe physical properties such as tender coconut size, weight, husk thickness, and husk moisture tender content play a vital role in the development of an efficient and ergonomic trimming machine. The important physical properties of tender coconuts of cultivars namely Kulasekaran Green Dwarf (KGD), Andaman Giant Tall (AGT), Ganga Bondam (GB), Malayan Orange Dwarf (MOD), and Chowghat Orange Dwarf (COD) were determined. The important properties including weight, diameter, height, husk thickness, husk moisture content, shell diameter, shell height, and shell thickness were high for nuts of AGT and low for COD nuts. The average bulk density, true density, and porosity of AGT were 332.47 kg m−3, 1,196.67 kg m−3, and 72.21%, respectively. The husk weight and volume of water of AGT were 87.77% and 12.39% high, respectively, compared with COD. In the correlation study, the coconut weight correlated positively (r = 0.791) with the diameter and vertical distance between the shell and the fruit base (r = 0.813). The principal component analysis suggested that the cultivars GB, KGD, and MOD have similar physical properties to COD and AGT. Thus, the present investigation documents crucial basic information to design an efficient and superior tender coconut trimming machine.ICA