67 research outputs found
A novel âcomplementâmetabolismâinflammasome axisâ as a key regulator of immune cell effector function
The inflammasomes are intracellular multiprotein complexes that induce and regulate the generation of the key proâinflammatory cytokines ILâ1ÎČ and ILâ18 in response to infectious microbes and cellular stress. The activation of inflammasomes involves several upstream signals including classic pattern or danger recognition systems such as the TLRs. Recently, however, the activation of complement receptors, such as the anaphylatoxin C3a and C5a receptors and the complement regulator CD46, in conjunction with the sensing of cell metabolic changes, for instance increased amino acid influx and glycolysis (via mTORC1), have emerged as additional critical activators of the inflammasome. This review summarizes recent advances in our knowledge about complementâmediated inflammasome activation, with a specific focus on a novel âcomplement â metabolism â NLRP3 inflammasome axis.
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