Dual equilibrium in a finite aspect ratio tokamak

A new approach to high pressure magnetically-confined plasmas is necessary to design efficient fusion devices. This paper presents an equilibrium combining two solutions of the Grad-Shafranov equation, which describes the magnetohydrodynamic equilibrium in toroidal geometry. The outer equilibrium is paramagnetic and confines the inner equilibrium, whose strong diamagnetism permits to balance large pressure gradients. The existence of both equilibria in the same volume yields a dual equilibrium structure. Their combination also improves free-boundary mode stability

True optical spacial derivatives for plasma density measurements

This paper shows analytically and numerically that a vortex plate coupled to a neutral density filter can deliver a true optical derivative when placed at the focal plane of a $2f$ lens pair. This technique turns spatial variations in intensity into an intensity, which square root is the spatial derivative of the initial intensity variation. More surprisingly, it also turns any spatial variations in phase into an intensity, which square root is the spatial derivative of the initial phase variation. Since the optical derivative drops the DC component of the signal, it is possible to measure the full electron plasma turbulence spectrum optically, without using any interferometer

Using LES to Study Reacting Flows and Instabilities in Annular Combustion Chambers

Great prominence is put on the design of aeronautical gas turbines due to increasingly stringent regulations and the need to tackle rising fuel prices. This drive towards innovation has resulted sometimes in new concepts being prone to combustion instabilities. In the particular field of annular combustion chambers, these instabilities often take the form of azimuthal modes. To predict these modes, one must compute the full combustion chamber, which remained out of reach until very recently and the development of massively parallel computers. Since one of the most limiting factors in performing Large Eddy Simulation (LES) of real combustors is estimating the adequate grid, the effects of mesh resolution are investigated by computing full annular LES of a realistic helicopter combustion chamber on three grids, respectively made of 38, 93 and 336 million elements. Results are compared in terms of mean and fluctuating fields. LES captures self-established azimuthal modes. The presence and structure of the modes is discussed. This study therefore highlights the potential of LES for studying combustion instabilities in annular gas turbine combustors

Prion Protein Is a Key Determinant of Alcohol Sensitivity through the Modulation of N-Methyl-D-Aspartate Receptor (NMDAR) Activity

The prion protein (PrP) is absolutely required for the development of prion diseases; nevertheless, its physiological functions in the central nervous system remain elusive. Using a combination of behavioral, electrophysiological and biochemical approaches in transgenic mouse models, we provide strong evidence for a crucial role of PrP in alcohol sensitivity. Indeed, PrP knock out (PrP−/−) mice presented a greater sensitivity to the sedative effects of EtOH compared to wild-type (wt) control mice. Conversely, compared to wt mice, those over-expressing mouse, human or hamster PrP genes presented a relative insensitivity to ethanol-induced sedation. An acute tolerance (i.e. reversion) to ethanol inhibition of N-methyl-D-aspartate (NMDA) receptor-mediated excitatory post-synaptic potentials in hippocampal slices developed slower in PrP−/− mice than in wt mice. We show that PrP is required to induce acute tolerance to ethanol by activating a Src-protein tyrosine kinase-dependent intracellular signaling pathway. In an attempt to decipher the molecular mechanisms underlying PrP-dependent ethanol effect, we looked for changes in lipid raft features in hippocampus of ethanol-treated wt mice compared to PrP−/− mice. Ethanol induced rapid and transient changes of buoyancy of lipid raft-associated proteins in hippocampus of wt but not PrP−/− mice suggesting a possible mechanistic link for PrP-dependent signal transduction. Together, our results reveal a hitherto unknown physiological role of PrP on the regulation of NMDAR activity and highlight its crucial role in synaptic functions

Unsteady simulation of an axial compressor stage with casing and blade passive treatments

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Numerical analysis of the tip leakage flow field in a transonic axial compressor with circumferential casing treatment

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