7 research outputs found
Stochastic theory of large-scale enzyme-reaction networks: Finite copy number corrections to rate equation models
Chemical reactions inside cells occur in compartment volumes in the range of
atto- to femtolitres. Physiological concentrations realized in such small
volumes imply low copy numbers of interacting molecules with the consequence of
considerable fluctuations in the concentrations. In contrast, rate equation
models are based on the implicit assumption of infinitely large numbers of
interacting molecules, or equivalently, that reactions occur in infinite
volumes at constant macroscopic concentrations. In this article we compute the
finite-volume corrections (or equivalently the finite copy number corrections)
to the solutions of the rate equations for chemical reaction networks composed
of arbitrarily large numbers of enzyme-catalyzed reactions which are confined
inside a small sub-cellular compartment. This is achieved by applying a
mesoscopic version of the quasi-steady state assumption to the exact
Fokker-Planck equation associated with the Poisson Representation of the
chemical master equation. The procedure yields impressively simple and compact
expressions for the finite-volume corrections. We prove that the predictions of
the rate equations will always underestimate the actual steady-state substrate
concentrations for an enzyme-reaction network confined in a small volume. In
particular we show that the finite-volume corrections increase with decreasing
sub-cellular volume, decreasing Michaelis-Menten constants and increasing
enzyme saturation. The magnitude of the corrections depends sensitively on the
topology of the network. The predictions of the theory are shown to be in
excellent agreement with stochastic simulations for two types of networks
typically associated with protein methylation and metabolism.Comment: 13 pages, 4 figures; published in The Journal of Chemical Physic
Weak noise approach to the logistic map
Using a nonperturbative weak noise approach we investigate the interference
of noise and chaos in simple 1D maps. We replace the noise-driven 1D map by an
area-preserving 2D map modelling the Poincare sections of a conserved dynamical
system with unbounded energy manifolds. We analyze the properties of the 2D map
and draw conclusions concerning the interference of noise on the nonlinear time
evolution. We apply this technique to the standard period-doubling sequence in
the logistic map. From the 2D area-preserving analogue we, in addition to the
usual period-doubling sequence, obtain a series of period doubled cycles which
are elliptic in nature. These cycles are spinning off the real axis at
parameters values corresponding to the standard period doubling events.Comment: 22 pages in revtex and 8 figures in ep
Theory connecting nonlocal sediment transport, earth surface roughness, and the Sadler effect
AbstractEarth surface evolution, like many natural phenomena typified by fluctuations on a wide range of scales and deterministic smoothing, results in a statistically rough surface. We present theory demonstrating that scaling exponents of topographic and stratigraphic statistics arise from longâtime averaging of noisy surface evolution rather than specific landscape evolution processes. This is demonstrated through use of "elastic" Langevin equations that generically describe disturbance from a flat earth surface using a noise term that is smoothed deterministically via sediment transport. When smoothing due to transport is a local process, the geologic record self organizes such that a specific Sadler effect and topographic power spectral density (PSD) emerge. Variations in PSD slope reflect the presence or absence and character of nonlocality of sediment transport. The range of observed stratigraphic Sadler slopes captures the same smoothing feature combined with the presence of longârange spatial correlation in topographic disturbance