20 research outputs found
Nomenclatural standards of pear varieties bred by Sverdlovsk Horticultural Breeding Station
As part of the research there have been developed and published nomenclatural standards of 12 pear varieties bred by Sverdlovsk Horticultural Breeding Station: Berezhenaya (WIR-101392), Gvidon (WIR-101393), Dobryanka (WIR-101394), Zarechnaya (WIR-101395), Permyachka (WIR-101397), Raduzhnaya (WIR-101398), Rozovyy Bochonok (WIR-101399), Sverdlovchanka (WIR-101400), Sultan (WIR-101402), Talitsa (WIR-101404), Fleyta (WIR-101405), Chusovaya (WIR-103944). Plant material for nomenclatural standards was selected in the collection of the originator organization with the participation of the creators of these varieties. The herbarium sample of the nomenclature standard of each cultivar is represented mainly by two herbarium sheets containing parts of one plant collected during two periods: fruit and annual shoots β in the fall 2019, flowers β in the spring 2020. The herbarium label indicates: the herbarium number of the sample in the VIR Herbarium, the scientific name of the species, the name of the variety, the origin (the name of the organization in which the variety was created), the place of reproduction (where the plant was grown), the harvest dates, the names of collectors. Herbarium sheets are supplemented with photos of fruits and flowers. Nomenclatural standards are made in accordance with the recommendations of the International Code of Nomenclature for Cultivated Plants (ICNCP), registered in the database "VIR Herbarium" and included in the type collection of Herbarium of cultivated plants of the world, their wild relatives and weeds (WIR). According to the same rules, herbarium samples of 3 elite pear forms (Limonadnaya, Sretenskaya, Tais) were made, registered and included into the Main Fund of the VIR Herbarium. After registration of copyright documents for cultivars, these samples can be assigned as nomenclatural standards. In total, 27 samples in the amount of 27 herbarium sheets were transferred to the herbarium collection. A digital image of herbarium specimen is available in the database Β«VIR HerbariumΒ» (http://db.vir.nw.ru/herbar/gerb)
Apple cultivars of baltic breeding in the herbarium collection of VIR
The most important purpose of the VIR Herbarium collection (WIR) is to document the cultivated flora and its dynamics. In particular, the herbarium should reflect the species and varietal composition of the live collections of the institute at different periods of time. The collection of apple (Malus domestica Borkh.) cultivars of Baltic breeding in the VIR Herbarium has been analyzed, and the cultivars from the collection maintained at the Science and Production Base "Pushkin and Pavlovsk laboratories of VIR" (SPB VIR), previously missing in the herbarium collection, herbarized. The collection contains 88 specimens of 56 apple cultivars of Baltic breeding, of which 38 specimens of 38 varieties were added to the collection in 2017
ΠΠΎΠ½ΠΎΠ»ΠΎΠ±Π°ΡΠ½Π°Ρ ΡΠΎΡΠΌΠ° Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΠ°ΡΠΎΠ»ΠΈ Ρ Π²Π½ΡΡΡΠΈΠΏΠ΅ΡΠ΅Π½ΠΎΡΠ½ΡΠΌ ΠΊΠΎΠ½ΠΊΡΠ΅ΠΌΠ΅Π½ΡΠΎΠΌ (ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅)
Caroliβs disease is a rare inherited disorder characterized by nonobstructive saccular or fusiform dilation of the intrahepatic bile ducts. Two main types of Caroliβs disease are reported, the true type with isolated dilation of intrahepatic bile ducts of single liver segment with formation of stones and development of cholangitis. The second type is combined with a congenital hepatic fibrosis. The true type of Caroliβs disease is distinct from primary sclerosing cholangitis, polycystic disease, cholangiolithiasis and other diseases. This paper presents a literature review and a case of monolobar Caroliβs disease with intrahepatic stones. The difficulties of preoperative differential diagnosis are shown.Β ΠΠΎΠ»Π΅Π·Π½Ρ ΠΠ°ΡΠΎΠ»ΠΈ (ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠ²Π½Π°Ρ ΠΊΠ°Π²Π΅ΡΠ½ΠΎΠ·Π½Π°Ρ ΡΠΊΡΠ°Π·ΠΈΡ ΠΆΠ΅Π»ΡΠ΅Π²ΡΠ²ΠΎΠ΄ΡΡΠΈΡ
ΠΏΡΡΠ΅ΠΉ) ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ΅Π΄ΠΊΠΈΠΌ Π½Π°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΡΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ΠΌ, ΠΊΠΎΡΠΎΡΠΎΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ Π½Π°Π»ΠΈΡΠΈΠ΅ΠΌ Π½Π΅ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠ²Π½ΡΡ
ΠΌΠ΅ΡΠΎΡΡΠ°ΡΡΡ
ΠΈΠ»ΠΈ Π²Π΅ΡΠ΅ΡΠ΅Π½ΠΎΠΎΠ±ΡΠ°Π·Π½ΡΡ
ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΠΉ Π²Π½ΡΡΡΠΈΠΏΠ΅ΡΠ΅Π½ΠΎΡΠ½ΡΡ
ΠΆΠ΅Π»ΡΠ½ΡΡ
ΠΏΡΠΎΡΠΎΠΊΠΎΠ². ΠΡΠ΄Π΅Π»ΡΡΡ 2 ΡΠΈΠΏΠ° Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΠ°ΡΠΎΠ»ΠΈ: ΠΈΡΡΠΈΠ½Π½ΡΠΉ ΡΠΈΠΏ Ρ ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ Π²Π½ΡΡΡΠΈΠΏΠ΅ΡΠ΅Π½ΠΎΡΠ½ΡΡ
ΠΆΠ΅Π»ΡΠ½ΡΡ
ΠΏΡΠΎΡΠΎΠΊΠΎΠ², Ρ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ, ΠΊΠ°ΠΊ ΠΏΡΠ°Π²ΠΈΠ»ΠΎ, ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΡΠ΅Π³ΠΌΠ΅Π½ΡΠ° ΠΈ ΡΠΎ ΡΠΊΠ»ΠΎΠ½Π½ΠΎΡΡΡΡ ΠΊ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΠ°ΠΌΠ½Π΅ΠΉ ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ Ρ
ΠΎΠ»Π°Π½Π³ΠΈΡΠ° ΠΈ Π²ΡΠΎΡΠΎΠΉ ΡΠΈΠΏ, ΠΊΠΎΡΠΎΡΡΠΉ ΡΠΎΡΠ΅ΡΠ°Π΅ΡΡΡ Ρ Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΡΠΌ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠ½ΡΠΌ ΡΠΈΠ±ΡΠΎΠ·ΠΎΠΌ. ΠΡΡΠΈΠ½Π½ΡΠΉ ΡΠΈΠΏ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΠ°ΡΠΎΠ»ΠΈ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²Π°ΡΡ Ρ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΠΌ ΡΠΊΠ»Π΅ΡΠΎΠ·ΠΈΡΡΡΡΠΈΠΌ Ρ
ΠΎΠ»Π°Π½Π³ΠΈΡΠΎΠΌ, ΠΏΠΎΠ»ΠΈΠΊΠΈΡΡΠΎΠ·ΠΎΠΌ, Ρ
ΠΎΠ»Π°Π½Π³ΠΈΠΎΠ»ΠΈΡΠΈΠ°Π·ΠΎΠΌ ΠΈ Π΄ΡΡΠ³ΠΈΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ. Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΠΎΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΈ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ ΠΌΠΎΠ½ΠΎΠ»ΠΎΠ±Π°ΡΠ½ΠΎΠΉ ΡΠΎΡΠΌΡ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΠ°ΡΠΎΠ»ΠΈ Ρ Π½Π°Π»ΠΈΡΠΈΠ΅ΠΌ Π²Π½ΡΡΡΠΈΠΏΠ΅ΡΠ΅Π½ΠΎΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΠΊΡΠ΅ΠΌΠ΅Π½ΡΠ°. ΠΠΎΠΊΠ°Π·Π°Π½Ρ ΡΡΡΠ΄Π½ΠΎΡΡΠΈ Π΄ΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ
Π ΠΠΠ£ΠΠ¬Π’ΠΠ’Π« ΠΠΠΠΠΠΠΠΠΠ― ΠΠΠΠΠ’Π£ΠΠ£ΠΠΠΠ Π ΠΠΠΠΠΠ Π‘ΠΠΠΠΠΠ Π’ΠΠ ΠΠΠΠ ΠΠΠΠΠ ΠΠΠ’ΠΠΠ¬ΠΠΠΠ Π ΠΠΠ Π‘ ΠΠΠ’ΠΠ‘Π’ΠΠΠΠΠ Π ΠΠΠ§ΠΠΠ¬
Panitumumab has been shown to increase progression free and overall survival in patients with metastatic colorectal cancer.Our purpose was to evaluate whether panitumumab is effective and safe in patients with potentially resectable colorectal liver metastases (CRLM).Methods. Consecutive analysis of data from 11 patients (KRAS wild) receiving oxaliplatin-based chemotherapy and panitumumab as converse preoperative treatment for potentially resectable CRLM. At the moment of presentation R0-liver resection was not possible due to technical reasons (small remnant volume, large liver vessels involvement etc.). We studied objective response rate, surgical characteristics, skin toxicity profile, and perioperative course. Also expression of EGFR-ligands (transforming growth factor-Ξ± and amphiregulin) and Β Β expression of E-cadherin were studied.Results. After median 6 courses of treatment, metastatic liver tumors were reduced considerably (PR) in 8 pts (73 %). Radical liver resection (R0) with 3 median number of removed segments was done in 6 (55 %) patients. Two pts underwent successfully the two-stage surgery (1 β portal vein embolization and 1 β portal vein ligation with partial left resection). Two patients progressed on chemotherapy (18 %). There was no correlation between skin toxicity and response. Mean blood loss was 250 ml. Preoperative administration of panitumumab was associated with higher risk of postoperative infection complication (57.1 %).Conclusions. To the best of our knowledge this is the first report about using panitumumab as conversion therapy before liver resection. The panitumumab and oxaliplatine-based regimen may increase the resection rate of liver metastases and influence on adhesive and proliferative activity of cancer cells. It is necessary to focus on postoperative infection complications.ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΠ°Π½ΠΈΡΡΠΌΡΠΌΠ°Π± ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π΅Ρ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ Π±Π΅Π· ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΠΎΠ±ΡΡΡ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·Π°ΠΌΠΈ ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° (ΠΠ Π ) Π² ΠΏΠ΅ΡΠ΅Π½Ρ.Π¦Π΅Π»ΡΡ Π½Π°ΡΠ΅Π³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ°Π»Π° ΠΎΡΠ΅Π½ΠΊΠ° Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ ΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π΄ΠΎΠ±Π°Π²Π»Π΅Π½ΠΈΡ ΠΏΠ°Π½ΠΈΡΡΠΌΡΠΌΠ°Π±Π° ΠΊ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎ ΡΠ΅Π·Π΅ΠΊΡΠ°Π±Π΅Π»ΡΠ½ΡΠΌΠΈ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·Π°ΠΌΠΈ.ΠΠ΅ΡΠΎΠ΄Ρ. Π ΠΊΠΎΠ³ΠΎΡΡΠ½ΠΎΠ΅ ΠΏΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π±ΡΠ»ΠΈ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ 11 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² (Π΄ΠΈΠΊΠΈΠΉ ΡΠΈΠΏ KRAS) Ρ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·Π°ΠΌΠΈ ΠΠ Π Π² ΠΏΠ΅ΡΠ΅Π½Ρ, ΡΠ°ΡΡΠ΅Π½Π΅Π½Π½ΡΠ΅ ΠΈΡΡ
ΠΎΠ΄Π½ΠΎ ΠΊΠ°ΠΊ Β«ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎ ΡΠ΅Π·Π΅ΠΊΡΠ°Π±Π΅Π»ΡΠ½ΡΠ΅Β» ΠΈ ΠΏΠΎΠ»ΡΡΠΈΠ²ΡΠΈΠ΅ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΊΠΎΠ½Π²Π΅ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΏΡΠ΅Π΄ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΠ°Π½ΠΈΡΡΠΌΡΠΌΠ°Π± Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠ΅ΠΉ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΎΠΊΡΠ°Π»ΠΈΠΏΠ»Π°ΡΠΈΠ½Π° Π² ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΠΈ Ρ
ΠΈΡΡΡΠ³ΠΈΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ, ΠΏΠΎΠ΄ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ ΠΈ ΠΆΠ΅Π»ΡΠ½ΡΡ
ΠΏΡΡΠ΅ΠΉ Π€ΠΠΠ£ Β«Π ΠΠ¦Π₯ ΠΈΠΌ. Π°ΠΊΠ°Π΄. Π.Π. ΠΠ΅ΡΡΠΎΠ²ΡΠΊΠΎΠ³ΠΎΒ» Π ΠΠΠ. Π ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΠΌ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠ°ΠΌ ΠΎΡΠ½ΠΎΡΠΈΠ»ΠΈΡΡ ΡΠ°ΡΡΠΎΡΠ° ΠΈ ΠΏΡΠΎΡΠ΅Π½Ρ ΠΎΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° ΠΏΠΎ ΠΊΡΠΈΡΠ΅ΡΠΈΡΠΌ RECIST 1.1, ΠΎΡΠ΅Π½ΠΊΠ° ΡΠ°ΡΡΠΎΡΡ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ ΡΠ΅Π·Π΅ΠΊΡΠΈΠΈ Π² ΠΎΠ±ΡΠ΅ΠΌΠ΅ R0, ΠΈΠ½ΡΡΠ°ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΠΈ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ, ΡΠ°ΠΊΠΈΠ΅ ΠΊΠ°ΠΊ ΠΊΡΠΎΠ²ΠΎΠΏΠΎΡΠ΅ΡΡ Π²ΠΎ Π²ΡΠ΅ΠΌΡ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ, ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ, Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΏΡΠ΅Π±ΡΠ²Π°Π½ΠΈΡ Π² ΡΡΠ°ΡΠΈΠΎΠ½Π°ΡΠ΅, ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΡ, 30-Π΄Π½Π΅Π²Π½Π°Ρ ΠΈ 90-Π΄Π½Π΅Π²Π½Π°Ρ Π»Π΅ΡΠ°Π»ΡΠ½ΠΎΡΡΡ. Π’Π°ΠΊΠΆΠ΅ ΠΈΠ·ΡΡΠ°Π»Π°ΡΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Π»ΠΈΠ³Π°Π½Π΄ΠΎΠ² ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ° ΡΠΏΠΈΠ΄Π΅ΡΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΡΠΎΡΠ° ΡΠΎΡΡΠ° (EGFR) β ΡΡΠ°Π½ΡΡΠΎΡΠΌΠΈΡΡΡΡΠ΅Π³ΠΎ ΡΠ°ΠΊΡΠΎΡΠ° ΡΠΎΡΡΠ° ΠΈ Π°ΠΌΡΠΈΡΠ΅Π³ΡΠ»ΠΈΠ½Π°, Π° ΡΠ°ΠΊΠΆΠ΅ E-ΠΊΠ°Π΄Π³Π΅ΡΠΈΠ½Π°.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΎΡΠ»Π΅ Π² ΡΡΠ΅Π΄Π½Π΅ΠΌ 6 ΠΊΡΡΡΠΎΠ² Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΠ°ΡΡΠΈΡΠ½ΡΠΉ ΠΎΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΎΡΠ²Π΅Ρ Π±ΡΠ» Π·Π°ΡΠ΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π½ Π² 73 % ΡΠ»ΡΡΠ°Π΅Π². Π Π°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΡΡ ΡΠ΅Π·Π΅ΠΊΡΠΈΡ ΠΏΠ΅ΡΠ΅Π½ΠΈ Ρ ΡΠ΄Π°Π»Π΅Π½ΠΈΠ΅ΠΌ Π² ΡΡΠ΅Π΄Π½Π΅ΠΌ 3 ΡΠ΅Π³ΠΌΠ΅Π½ΡΠΎΠ² ΡΠ΄Π°Π»ΠΎΡΡ Π²ΡΠΏΠΎΠ»Π½ΠΈΡΡ Π² ΠΎΠ΄ΠΈΠ½ ΡΡΠ°ΠΏ Ρ 6 (55 %) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². ΠΠ²Π° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° ΡΡΠΏΠ΅ΡΠ½ΠΎ Π·Π°Π²Π΅ΡΡΠΈΠ»ΠΈ Π΄Π²ΡΡ
ΡΡΠ°ΠΏΠ½ΠΎΠ΅ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ (1 β ΡΠΌΠ±ΠΎΠ»ΠΈΠ·Π°ΡΠΈΡ Π²ΠΎΡΠΎΡΠ½ΠΎΠΉ Π²Π΅Π½Ρ ΠΈ 1 β ΠΏΠ΅ΡΠ΅Π²ΡΠ·ΠΊΠ° ΠΏΡΠ°Π²ΠΎΠΉ Π²ΠΎΡΠΎΡΠ½ΠΎΠΉ Π²Π΅Π½Ρ Ρ ΡΠ΅Π³ΠΌΠ΅Π½ΡΠ°ΡΠ½ΠΎΠΉ Π»Π΅Π²ΠΎΡΡΠΎΡΠΎΠ½Π½Π΅ΠΉ ΡΠ΅Π·Π΅ΠΊΡΠΈΠ΅ΠΉ). Π£ 2 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π±ΡΠ»Π° Π·Π°ΡΠΈΠΊΡΠΈΡΠΎΠ²Π°Π½Π° ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡ Π½Π° ΡΠΎΠ½Π΅ Π»Π΅ΡΠ΅Π½ΠΈΡ. ΠΠΎΡΡΠ΅Π»ΡΡΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΠ΅ΠΏΠ΅Π½ΡΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ ΠΊΠΎΠΆΠ½ΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΠΈ ΠΎΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΠΎΡΠ²Π΅ΡΠΎΠΌ ΠΎΡΡΡΡΡΡΠ²ΠΎΠ²Π°Π»Π°. ΠΠ΅Π΄ΠΈΠ°Π½Π° ΠΊΡΠΎΠ²ΠΎΠΏΠΎΡΠ΅ΡΠΈ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 250 ΠΌΠ». ΠΡΠ΅Π΄ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½Π°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ ΠΏΠ°Π½ΠΈΡΡΠΌΡΠΌΠ°Π±ΠΎΠΌ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π»Π°ΡΡ ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΡΠΌ ΡΠΈΡΠΊΠΎΠΌ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ (57,1 %).ΠΡΠ²ΠΎΠ΄Ρ. ΠΠΎ Π½Π°ΡΠΈΠΌ Π΄Π°Π½Π½ΡΠΌ, ΡΡΠΎ ΠΏΠ΅ΡΠ²ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅, Π² ΠΊΠΎΡΠΎΡΠΎΠΌ ΠΈΠ·ΡΡΠ°Π»ΠΎΡΡ Π΄ΠΎΠ±Π°Π²Π»Π΅Π½ΠΈΠ΅ ΠΏΠ°Π½ΠΈΡΡΠΌΡΠΌΠ°Π±Π° ΠΊ ΠΊΠΎΠ½Π²Π΅ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΠ Π Π΄ΠΎ ΡΠ΅Π·Π΅ΠΊΡΠΈΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ. Π Π΅ΠΆΠΈΠΌ Π»Π΅ΡΠ΅Π½ΠΈΡ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΏΠ°Π½ΠΈΡΡΠΌΡΠΌΠ°Π±Π° ΠΈ ΠΎΠΊΡΠ°Π»ΠΈΠΏΠ»Π°ΡΠΈΠ½Π° ΠΌΠΎΠΆΠ΅Ρ ΡΠ²Π΅Π»ΠΈΡΠΈΡΡ ΡΠ°ΡΡΠΎΡΡ ΡΡΠΏΠ΅ΡΠ½ΡΡ
ΡΠ΅Π·Π΅ΠΊΡΠΈΠΉ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΈ Π²Π»ΠΈΡΡΡ Π½Π° Π°Π΄Π³Π΅Π·ΠΈΠ²Π½ΡΠ΅ ΠΈ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ. ΠΠ΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ ΡΠ΄Π΅Π»ΡΡΡ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ.
Features of autonomic regulation in cholelithiasis before and after cholecystectomy
It is appropriate and necessary to examine the functional state of the autonomic nervous system and the quality of life in patients with cholelithiasis using the mathematical analysis of the heart rhythm at the present-day level. Materials and methods: 136 patients (115 women and 21 men) were examined, of which 70 patients after cholecystectomy with cholelithiasis and 66 patients with cholelithiasis. Fractional chromatic minute-type duodenal intubation with an analysis of the biochemical and microscopic composition of the bile was used to assess the biliary system condition. The examination of the autonomic nervous system was carried out by determining the heart rhythm using the cardiointervalography method with further mathematical analysis of the structure and variational pulsometry. Changes in the autonomic status in patients with cholelithiasis before and after cholecystectomy differ in general patterns: adaptive possibilities decrease and sympathetic activity of the autonomic regulation increases. An increase in the lithogenicity of bile, which positively correlates with the level of sympathicotonia, is characteristic for patients with cholelithiasis before and after cholecystectomy. The autonomic regulation in patients with cholelithiasis after cholecystectomy improves, however, the high bile lithogenicity persists
RESULTS OF PANITUMUMAB ADDITION TO CONVERSION THERAPY FOR COLORECTAL CANCER LIVER METASTASES
Panitumumab has been shown to increase progression free and overall survival in patients with metastatic colorectal cancer.Our purpose was to evaluate whether panitumumab is effective and safe in patients with potentially resectable colorectal liver metastases (CRLM).Methods. Consecutive analysis of data from 11 patients (KRAS wild) receiving oxaliplatin-based chemotherapy and panitumumab as converse preoperative treatment for potentially resectable CRLM. At the moment of presentation R0-liver resection was not possible due to technical reasons (small remnant volume, large liver vessels involvement etc.). We studied objective response rate, surgical characteristics, skin toxicity profile, and perioperative course. Also expression of EGFR-ligands (transforming growth factor-Ξ± and amphiregulin) and Β Β expression of E-cadherin were studied.Results. After median 6 courses of treatment, metastatic liver tumors were reduced considerably (PR) in 8 pts (73 %). Radical liver resection (R0) with 3 median number of removed segments was done in 6 (55 %) patients. Two pts underwent successfully the two-stage surgery (1 β portal vein embolization and 1 β portal vein ligation with partial left resection). Two patients progressed on chemotherapy (18 %). There was no correlation between skin toxicity and response. Mean blood loss was 250 ml. Preoperative administration of panitumumab was associated with higher risk of postoperative infection complication (57.1 %).Conclusions. To the best of our knowledge this is the first report about using panitumumab as conversion therapy before liver resection. The panitumumab and oxaliplatine-based regimen may increase the resection rate of liver metastases and influence on adhesive and proliferative activity of cancer cells. It is necessary to focus on postoperative infection complications
THE INFLUENCE OF INDAPAMIDE ON BLOOD PRESSURE DAILY PROFILE, HEMODYNAMICS AND RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN HYPERTENSIVE PATIENTS OLDER THAN 55 YEARS
With the aim of studing influense of 3-12 mounth therapy of indapamide at the daily profile of blood pressure, condition of central hemodynamic and RAAS, were examined 121 patients older than 55 years old.We noted, that systolic blood pressure reduce on 19% and diastolic one on the 14%, mainly because of decrease of common peripheral vascular resistance. At the same time the levels of renin and aldosterone were diminished, while cardiopump function, lipid, carbohydrate and electrolyte metabolism were not changed
MOBILIZATION OF VEGETABLE AND CUCURBIT CROP GENETIC RESOURCES IN THE 21<sup>st</sup> CENTURY
The worldwide collection of vegetable and cucurbit crops kept in VIR includes 50,019 accessions of various status -representatives of 27 families, 145 genera, 475 species received since 1923 from 95 countries of the world. Biodiversity of cultivated species and their wild relatives, especially from their centres of origin and diversity, is adequately represented in the collection. Currently, the completion of the collection is conducted in the following areas: collection of wild species and local forms with a high level of resistance to biotic and abiotic stresses, and with valuable biochemical composition; replenishment of the collection with accessions missing in the evolutionary series of vegetable crops from their ancestral forms to modern varieties and lines, including those needed for the analysis of domestication processes; introduction of crops and types of varieties novel for Russia; mobilization of the worldβs best achievements in modern breeding, first of all in the newest breeding trends; mobilization of new genetic material -mutant lines, double haploid lines, and mapping populations