Synthesis, Morphostructure, Surface Chemistry and Preclinical Studies of Nanoporous Rice Husk-Derived Biochars for Gastrointestinal Detoxification

This article summarizes the methodology of synthesis, surface functionalization and structural properties of rice husk-derived nanostructured carbon enterosorbents (biochars) in connection with the preliminary in vitro study results of uraemic toxin adsorption in model experiments, as well as preclinical trials in vivo. The obtained nanostructured carbon sorbents were studied using a number of modern physicochemical methods of investigation: low-temperature nitrogen adsorption, isotherms recording and calculation of the specific surface area, pore volumes were carried out using the Autosorb-1 "Quantachrome" device. Scanning electron microscopy and EDS-analysis. Mercury intrusion porosimetry analysis of the ACs were accomplished using "Quantachrome Poremaster" data analysis software. In vitro adsorption results assessed by use of HPLC and UV-spectroscopy for the nanostructured carbon sorbents with respect to the investigated low-molecule toxins suggest that the rice husks-derived carbon enterosorbents modified with the functional groups are able to reduce clinically significant levels of uraemic toxins and are comparable to the commercial enterosorbents. Based on the results of the comparative analysis for biocompatibility of canine kidney epithelial cells it was determined that the samples of the modified sorbents CRH P 450 and CRH 475 KOH 850 N do not exhibit cytotoxicity in comparison with the commercial carbon enterosorbent «Adsorbix Extra». According to the results of the in vivo studies, it was determined that there was a the positive effect of enterosorbent on uremia and intoxication

Efficacy of Application of Dietary Supplements in Acute Intoxication

The effectiveness of BAA balsam "Revival plus" as a means of pharmacological correction of neurotoxic and hepatotoxic lesions as consequences of acute ethanol poisoning was evaluated. It has been established that in the conditions of acute severe intoxication ethanol BAA balsam "Revival plus" has pharmacological efficacy in terms of survival keeping temperature and frequency of respiratory movements in poisoned rats with a therapeutic and prophylactic scheme of their use. Value of the work consists in the experimental substantiation of the possibility of using BAA balsam "Revival plus" as a promising means of treatment of acute extremely severe ethanol poisoning. The aim of this paper is to demonstrate the efficacy of application of dietary supplements in acute intoxication, to depict the effectiveness of balsam during the intoxication, and from scientific purpose to prove the significance of this supplement. The obtained data testify to the effectiveness of the use of bio additives in ethanol poisoning and possible mechanisms for the implementation of the hepatic protective effect of the BAA balsam "Revival Plus" under various life-threatening conditions. The purpose of this research is evaluation of the experimental effectiveness of BAA balsam "Revival Plus" for ethanol poisoning. To achieve this goal the following tasks are set: To reveal the features of the histological structure of the liver of control and experimental rats of the second group with ethanol poisoning; To study the morphological changes in the liver of rats of the third group with ethanol poisoning against the background of the use of BAA balsam "Revival plus"; To study the peculiarities of the action of the BAA balsam "Revival plus" on the biochemical parameters of the blood of rats. Questions about the interaction of dietary supplements and alcoholic beverages are regularly being raised by both researchers and ordinary consumers. In most cases talk about the dangers of dietary supplements for a person who often drinks alcoholic beverages is not necessary

Study of qualitative and quantitative indicators of the spermatogenesis for determination of the effectiveness of cryopreservation

Semen or spermatozoa cryopreservation (commonly called sperm banking) is a procedure to preserve sperm cells. Semen can be used successfully indefinitely after cryopreservation and might be stored successfully over 20 years. It can be used for sperm donation where the recipient wants the treatment in a different time or place, or as a means of preserving fertility for men undergoing vasectomy or treatments that may compromise their fertility, such as chemotherapy, radiation therapy or surgery. However, before the cryopreservation, it is necessary to check the parameters of the ejaculate and treat the sperm in a special container (a small in diameter plastic box with information about the patient) to increase the concentration of spermatozoa. Put the container for storage into Dewar tube. In some cases, cryopreservation might worsen the quality of the ejaculate. After freezing, the mobility and morphology of the sperm can deteriorate. Thus, it is desirable to carry out freezing in test conditions to determine the need for the frozen material. Especially when spouses plan to use additional fertilization programs, this approach should be taken into account, since cryopreservation might cause a spontaneous change in the program of intracytoplasmic vaccination of the spouse. One of the methodological problems of cryopreservation is poor quality of the ejaculate, i.e. when freezing spermatozoa, their activity and function deteriorate from the norm. This reduces the possibility of using them in the future for artificial insemination. Results of the experiment show that cryof preservation is possible only in specialized centers with the highest professional standards

Increase of Healthy Food Quality among the Kazakhstan Population

At present, one of the most important urgent issues is the study of healthy nutrition of the population of Kazakhstan. Proper nutrition ensures the growth and development of children, contributes to the prevention of diseases, increase the capacity for work and prolong the life of people, while creating conditions for adequate adaptation to the environment.Most of the population of Kazakhstan because of technological processing, the use of inadequate food raw materials, influence of other causes, does not receive the necessary amount of essential components of food, which lead to illnesses, premature aging and shortening of life.The situation aggravates by the low cultural level of the population in matters of rational nutrition and the lack of skills for healthy lifestyles.In this regard, the main task in the work was to study methods of improving the health and quality of life of the population of Kazakhstan, especially those living in zones of environmental problems and contacting with harmful factors

The Study of Hematological Parameters of Animals in the Application of Enterosorbent Food Fiber

One of the most important issues is the study of healthy nutrition of the population of Kazakhstan. Proper nutrition provides growth, contributes to the prevention of diseases, increase efficiency and prolong life of people, while creating conditions for adequate adaptation to the environment. A large part of the population of Kazakhstan as a result of technological processing, the use of inferior in chemical composition of food raw materials, the influence of other causes, does not receive the necessary amount of essential components of food, which lead to illness, premature old age and shortened life. The situation is aggravated by the low cultural level of the population in terms of good nutrition and the lack of skills to lead a healthy lifestyle. The problem of quality and food safety, while food must have not only nutritional and physiological value, but also perform preventive functions

Estimation of Efficiency of Use of Dairy Products Enriched with Enter Sorbent Dietary Fibers on Immunophysiological Indicators of the Rat Organism

At all times, the problem of healthy and wholesome food has been one of the most important problems facing human society. This problem cannot be solved by simply increasing the amount of food consumed. Plant-based antioxidants are widely used for the prevention and treatment of diseases with the aim of eliminating free radicals from the body and restoring the body's antioxidant defense system. The article shows biochemical indicators that reflect the nature of changes in the early stages of the formation of response of the animal organism during toxic poisoning and the use of sour-milk products using enter sorbent dietary fiber from rice husk. With an increase in the dosage and frequency of CCl4 administration, the effect of deep poisoning and impaired lymph dynamics was obtained. Along with a decrease in the content of total protein and urea in lymph and blood plasma, an increase in ALT and AST levels in blood plasma by 2.5–3 times, as well as an increase in thymol test, were noted. Antioxidant defense mechanisms are universal in order to increase the body's vitality