Применение планиметрического анализа при изучении заживления ожоговых ран у животных

The results of these studies are the basis for using a wound dressing based on bacterial cellulose in the comprehensive pathogenetic therapy of burn wounds. The process was studied on a model of III B degree planar burn wounds of rabbits. The experimental studies of the efficiency of the Derma RM wound covering have shown that its use in local treatment of uninfected deep burns prevents complications of the process of wound healing, and reduces the wounds healing time.Результаты проведенных исследований являются основанием применения раневого покрытия на основе бактериальной целлюлозы в комплексной патогенетической терапии ожоговых ран. Исследование процесса проведено на модели ожоговых плоскостных ран кроликов III Б степени. Экспериментальные исследования эффективности раневого покрытия «Derma RM» показали, что применение при местном лечении неинфицированных глубоких ожогов предупреждает осложнение раневого процесса и сокращает сроки заживления ран

APPROACHES TO THE FUTURE ENGINEERS FOREIGN COMMUNICATIVE CULTURE FORMATION

Purpose: The main aim of the article is to define the approaches to the formation of future engineers’ communicative culture. The main research method used while working on the article is analysis of the domestic and foreign publication space for critical consideration of different ideas on the pedagogical problem of the future engineers’ foreign language communicative culture formation process. Methodology: In this study Content abstraction, generalization and the comparative method was applied. Result: The approaches (cultural, connectivism, technological, axiological, communicative, environmental approach) will help to the formation of the communicative culture of future engineers in the process of foreign language training. Applications: This research can be used for engineers and companies. Novelty/Originality: In this research, the model of approaches to future engineers' foreign communicative culture formation is presented in a comprehensive and complete manner

Control of microimpurities emitted from polymer construction materials based on polyvinyl chloride

The aim of this article is to improve the degree control of microimpurities emitted from polymeric construction materials into the environment. It is proposed to do this through the modification of the physicochemical nature of the original (source) sorbent and, as a consequence, the improvement of the sorption capacity and the extraction ratio of highly volatile toxic substances. The proposed concentrator columns can be widely used in the analysis of microimpurities of polar organic substances released into the environment from polymeric construction materials based on polyvinyl chloride

Control of microimpurities emitted from polymer construction materials based on polyvinyl chloride

The aim of this article is to improve the degree control of microimpurities emitted from polymeric construction materials into the environment. It is proposed to do this through the modification of the physicochemical nature of the original (source) sorbent and, as a consequence, the improvement of the sorption capacity and the extraction ratio of highly volatile toxic substances. The proposed concentrator columns can be widely used in the analysis of microimpurities of polar organic substances released into the environment from polymeric construction materials based on polyvinyl chloride

Lack of GAGA protein in Trl mutants causes massive cell death in Drosophila spermatogenesis and oogenesis

Drosophila protein GAGA (GAF) is a factor of epigenetic transcription regulation of a large group of genes with a wide variety of cellular functions. GAF is encoded by the Trithorax-like (Trl) gene, which is important for the formation of various organs and tissues at all stages of ontogenesis. In our previous works, we showed that this protein is necessary for the development of the reproductive system, both in males and females of Drosophila. Decreased expression of the Trl gene led to multiple disorders of spermatogenesis and oogenesis. One of the significant disorders was associated with massive degradation and loss of cells in the germline. In this work, we carried out a more detailed cytological study to determine what type of germ cell death is characteristic of Trl mutants, and whether there are disturbances or changes in this process compared to the norm. The results obtained showed that the lack of GAF protein causes massive germ cell death in both females and males of Drosophila, but this death manifests itself in different ways, depending on the sex. In Trl females, this process does not differ phenotypically from the norm. In the dying egg chambers, signs of apoptosis and autophagy were revealed, as well as morphological features that are characteristic of the wild type. In males, Trl mutations induce mass germ cell death through autophagy, which is not typical of Drosophila spermatogenesis, and has not been previously described, neither in the norm nor in other genes’ mutations. Thus, GAF lack in Trl mutants leads to increased germ cell death through apoptosis and autophagy. Ectopic cell death and germ line atrophy are probably associated with impaired expression of the GAGA factor target genes, among which there are genes that regulate both apoptosis and autophagy

MODY2 diagnostic issues in adults

Approximately 90% of all cases of diabetes mellitus in adults involve type 2 diabetes, while the prevalence of maturity-onset diabetes of the young (MODY) remains undetermined leading to inappropriate treatment regimens. One of the most common monogenic forms of diabetes is a disease caused by a mutation in the glucokinase gene, MODY2. Knowledge of the clinical features of the disease allows the selection of patients with a high risk of mutation in the glucokinase gene and verification of diagnosis for molecular genetic research. This paper reflects the clinical features of MODY2 and the difficulties of diagnosis in adults. Furthermore, it presents a clinical case of a patient with MODY2 demonstrating all the features of this type of diabetes. A family member with a mutation in the gene allows to predict the nature of carbohydrate metabolism disorders in first degree relatives. A targeted study of only one part of the glucokinase gene in molecular genetic research is sufficient to confirm the diagnosis in relatives

Cholera Vibrios non-O1/non-O139 Isolated in the Process of Epidemiological Monitoring over Rostov-on-Don Water Basins and Drain Sewage System within the Period of 2009–2011

Studied have been biological properties of cholera vibrios non-O1/non-O139 circulating in the Rostov-on-Don surface waters and drain sewage system within the period of 2009–2011. Overwhelming majority of the isolates have been classified as typical ones in terms of their phenotype. However 90 strains (21 %) out of total 280 have been identified as atypical ones against agglu­tina­bility in the slide-agglutination and full-scale agglutination reaction to diagnostic cholera sera. Put forward are recommendations on performance of the differentiation between V. cholerae non-O1/non-O139 and V. cholerae O1/O139. Specified are predominant sero­groups of the strains which turned to be unchanged within the stated period (O16, O53, O76, and O67). Revealed is the strain genotype variability and low probability of virulence manifestations. Demonstrated is the futility of the blind gene- and serological typing of aquatic strains

Ultrasonic predictors of macrosomia in gestational diabetes mellitus

BACKGROUND: The basis of early ultrasound (US) diagnosis of diabetic fetopathy (DF) in pregnant with gestational diabetes mellitus (GDM) is the forehanded detection of macrosomia, especially its asymmetric forms. In pregnant with GDM on a diet therapy, the detection of macrosomia may be an indication for starting the insulin therapy. In pregnant with hyperglycemia due to mutation in the glucokinase gene (GCK), US fetal growth dynamics helps to assume the fetal genotype, as well as to stratify the risks of insulin therapy. AIM: To determine the prognostic significance of asymmetric form of macrosomia and the value of the coefficients of proportionality for the diagnosis of DF in pregnant with GDM, including hyperglycemia due to mutation in the GCK gene. MATERIALS AND METHODS: US fetometry was performed in 95 pregnant with GDM (including 22 pregnant with hyperglycemia caused by mutation in the GCK gene) (main group) and 427 healthy pregnant women (control group). Estimated fetal weight, standard fetometric indicators and coefficients of proportionality were evaluated. Retrospective analysis of US predictors of macrosomia was carried out after evaluating the weight of the newborn and clarifying the signs of DF. RESULTS: In the group with GDM, 51 (53.7%) pregnant had children with phenotypic symptoms of DF, including macrosomia – 66,7% (34 children). We found statistically significant differences in fetal weight between the control group and the main group who gave birth to children with DF starting from 32 weeks. The coefficients of proportionality (femur length/abdominal circumference and the head circumference/abdominal circumference), characterizing the formation of the asymmetric macrosomia were significantly from 34 weeks (Р<0,05). CONCLUSION: The most effective predictive fetometric indicators for the diagnosis of fetal macrosomia are the dimensions of fetal abdomen and fetal weight > 90 percentile for gestational age. A specific sign of DF in pregnant with GDM is the asymmetric macrosomia. In pregnant with a mutation in the GCK gene, the tendency to macrosomia was revealed only in the absence of a mutation in the fetus, but insulin therapy in the presence of a similar mutation in fetus did not lead to a significant decrease in its percentile ranges

Erratum: a synonymous variant in GCK gene as a cause of gestational diabetes mellitus (diabetes mellitus. 2019;22(2). Doi: 10.14341/dm9938)

An erratum on «A synonymous variant in GCK gene as a cause of gestational diabetes mellitus» by Natalya A. Zubkova, Petr M. Rubtsov, Liudmila I. Ibragimova, Nina A. Makretskaya, Evgeny V. Vasiliev, Vasily M. Petrov, Anatoly N. Tiulpakov (2019). Diabetes mellitus. 22(2). doi: 10.14341/DM9938An error was made in the list of authors: Fatima F. Burumkulova was not indicated as author of this article. The correct list of authors: Natalya A. Zubkova, Petr M. Rubtsov, Fatima F. Burumkulova, Liudmila I. Ibragimova, Nina A. Makretskaya, Evgeny V. Vasiliev, Vasily M. Petrov, Anatoly N. Tiulpakov.The editorial board apologize for this error and state that this does not change the scientific conclusions of the article in any way.The original article has been updated