Синтез, микроструктура и магнитные свойства магнитомягких пленок СоР

Soft magnetic thin CoP films were obtained by means of chemical metallization from aqueous cobalt salt solution in the presence of sodium hydroxide, citric acid and sodium hypophosphite as the reducing agent. The optimal values of the magnetic film parameters (saturation magnetization and width of ferromagnetic resonance line) were obtained by variation of composition of work solutions. It allows to reduce losses in their application in microwave devices. Microphotographs of magnetic film indicate a grain structure with a grain size of about 50 nm and presence of inclusions with the size of 3-5 nm. To determine the magnetic parameters of the investigated films the method of ferromagnetic resonance (FMR) absorption curves processing is used. The values of FMR line width and an effective magnetization of film material saturation were obtained.Приведены результаты исследования свойств магнитомягких тонких пленок СоР, полученных методом химической металлизации из водного раствора на основе цитратных комплексов с применением в качестве щелочного реагента NaOH. С помощью вариации составов рабочих растворов получены оптимальные значения магнитных параметров пленок: намагниченности насыщения и ширины линии ферромагнитного резонанса

Многоуровневые инъекции ботулинического токсина типа А (Абоботулотоксина) при лечении спастических форм детского церебрального паралича: ретроспективное исследование опыта 8 российских центров

Background: The contemporary application of Botulinum toxin A (BTA) in cerebral palsy (CP) implies multilevel injections both in on-label and off-label muscles. However, there is no single international opinion on the effective and safe dosages, target muscles, and intervals between the injections.Objective: Our aim was to analyze the Russian multicenter independent experience of single and repeated multilevel injections of Abobotulinum toxin А in patients with spastic forms of CP.Methods: 8 independent referral CP-centers (10 hospitals) in different regions of Russia. Authors evaluated intervals between the injections, dosages of the BTA for the whole procedure, for the body mass, for the each muscle, and functional segment of the extremities.Results: 1872 protocols of effective BTA injections (1–14 repeated injections) for 724 patients with spastic CP were included. The age of the patients was between 8 months to 17 years 4 months at the beginning of the treatment (with a mean of 3 years 10 months). Multilevel BTA injections were indicated for the majority (n = 634, 87.6%) of the patients in all the centers. The medians of the dosages for the first BTA injection were between 30–31 U/kg (500 U), the repeated injections doses up to 45 U/kg (1000 U) (in most centers). The median intervals between the repeated injections were 180–200 days in 484 (66.9%) patients and 140–180 days in 157 (24.7%) patients. In 2 centers, children with GMFCS IV–V were injected more often than others.Conclusion: Multilevel BTA injections were indicated for the most patients. The initial dose of Abobotulinum toxin A was 30–31 U/kg. The repeated injections dose could increase up to 40 U/kg. The repeated injections were done in 140–200 days after the previous injection.Современная концепция ботулинотерапии при детском церебральном параличе (ДЦП) предлагает использование многоуровневых инъекций в расширенное число мышц. Однако по-прежнему отсутствует консенсус относительно выбора оптимальных доз, мышц и интервалов между инъекциями.Цель исследования: изучить российский опыт применения однократных и повторных многоуровневых инъекций абоботулотоксина при лечении спастичности у пациентов с ДЦП.Методы: в ретроспективном исследовании проанализирован опыт ботулинотерапии при ДЦПв 8 специализированных центрах России. Изучали протоколы клинически эффективных инъекций. Оценивали общие дозы препарата БТА, дозы на единицу массы тела пациентов, на всю инъекционную сессию и отдельные мышцы, а также интервалы между инъекциями.Результаты: изучено 1872 протокола клинически эффективных инъекций, всего от 1 до 14 повторных инъекций, сделанных 724 пациентам в возрасте от 8 мес до 17 лет 4 мес (медиана возраста на момент первой инъекции БТА — 3 года 10 мес) на момент начала ботулинотерапии. Большинство пациентов (n = 634; 87,6% инъекций) получили многоуровневую ботулинотерапию. Во всех центрах при первичных инъекциях БТА медиана доз находилась в пределах 30–31 Ед/кг массы тела (общая — 500 Ед). При повторных инъекциях в большинстве учреждений максимальные дозы превышали 45 Ед/кг (1000 Ед). Средние интервалы между повторными инъекциями колебались в пределах 140–180 сут для 157 (24,7%) и 180–200 сут для 484 (66,9%) пациентов. В 2 из 8 центров пациенты с наиболее выраженными двигательными нарушениями (GMFCS IV–V) требовали более частых повторных инъекций БТА.Заключение: в специализированных центрах большинству пациентов с ДЦП ботулинотерапию проводили по многоуровневой схеме. Общая доза абоботулотоксина при первичных инъекциях составляла 30–31 Ед/кг; при повторных инъекциях она могла быть увеличена до 40 Ед/кг и более. Вопрос о повторном проведении инъекции БТА рассматривался в интервале 140–200 сут после предшествующей инъекции

Synthesis, Microstructure and Magnetic Properties of Soft Magnetic CoP Films

Soft magnetic thin CoP films were obtained by means of chemical metallization from aqueous cobalt salt solution in the presence of sodium hydroxide, citric acid and sodium hypophosphite as the reducing agent. The optimal values of the magnetic film parameters (saturation magnetization and width of ferromagnetic resonance line) were obtained by variation of composition of work solutions. It allows to reduce losses in their application in microwave devices. Microphotographs of magnetic film indicate a grain structure with a grain size of about 50 nm and presence of inclusions with the size of 3-5 nm. To determine the magnetic parameters of the investigated films the method of ferromagnetic resonance (FMR) absorption curves processing is used. The values of FMR line width and an effective magnetization of film material saturation were obtained

EFFECTS OF TRIMETAZIDINE ON THE TRANSMITRAL BLOOD FLOW IN PATIENTS WITH DIASTOLIC HEART FAILURE

Aim. To study effects of trimetazidine on the left ventricular diastolic dysfunction in patients with combination of ischemic heart disease (IHD) and arterial hypertension (HT). Material and methods. Patients with IHD and HT (n=154) were divided into two treatment groups. Patients of the main groups (n=72) received standard therapy and trimetazi- dine 35 mg twice a day. The patients of the control group (n=82) received only standard therapy. Echocardiographic parameters, including mitral Doppler flow indices were as- sessed at baseline and after 2 months.Subgroups of patients were identified by type of left ventricle diastolic function according to echocardiographic data. Changes in echocardiographic indicators were evaluated in these subgroups separately and compared in the main and control groups.Results. The subgroups of patients with impaired relaxation (n=54), pseudonormalization (n=48) and restriction (n=52) were identified in the main and control groups according to echocardiographic data. A significant increase in the period of early left ventricle filling (27.6%, p&lt;0.05) and the ratio of the two phases of left ventricle filling (37.8%, p&lt;0.001) were found in patients with impaired relaxation treated with trimetazidine. Other studied parameters of mitral flow in the other patient subgroups were not significantly changed. Conclusion. Trimetazidine 70 mg daily in the 2 month treatment of diastolic heart failure in patients with IHD and HT resulted in significant improvement of some indicators of mitral blood flow only in patients with type I diastolic dysfunction (impaired relaxation).</p

EFFECT OF SIMVASTATIN THERAPY ON INDICATORS OF TRANSMITRAL BLOOD FLOW IN PATIENTS WITH DIASTOLIC HEART FAILURE

Aim. To study the effect of simvastatin added to standard therapy on the left ventricular structure functional status in patients with diastolic chronic heart failure (CHF).Material and methods. Patients (n=125) with diastolic CHF (relaxation disturbances and pseudonormalization) were included into the open nonrandomized study. Patients of the main group (n=66) received simvastatin additionally to standard therapy of CHF. Patients of control group (n=59) received standard therapy only. Initially and after 6 months of treatment Doppler echocardiography (EchoCG) was performed with assessment of transmitral blood flow indices. On the basis of EchoCG data diastolic dysfunction types were determined in patients of the main group. Dynamics of EchoCG indices were evaluated in accordance with these types.Results. Significant increase in E (peak early diastolic left ventricular filling velocity) value by 14.1% (p&lt;0.001) and E/A (where A - peak left ventricular filling velocity at atrial contraction) ratio by 18.7% (p&lt;0.001) was found in the main group in estimating of transmitral flow indicators. Deceleration time of early diastolic filling significantly decreased by 7.8% (p&lt;0.01). Other parameters did not change significantly both in the main and control groups. Intra-group comparison in the main group demonstrated that transmitral blood flow indices changed significantly only in patients with delayed relaxation (type I of diastolic dysfunction).Conclusion. Simvаstatin added to standard therapy of CHF resulted in significant improvement in the left ventricle diastolic function

Indium–tin oxide films obtained by extraction pyrolysis

Текст статьи не публикуется в открытом доступе в соответствии с политикой журнала.Thin indium–tin oxide (ITO) films were obtained by pyrolysis of solutions of indium and tin extracts on glass substrates. The extraction pyrolysis (EP) technology uses inexpensive starting compounds and provides the required stoichiometric ratio of elements due to complete mixing of precursors in the organic solution. The thermal decomposition of the extracts occurs in a narrow temperature range of 350– 400°C. X Ray photoelectron spectroscopy (XPS) studies showed that the ITO films obtained by extraction pyrolysis have no impurities including carbon. The films have a nanocrystalline structure with a grain size of ~6 nm according to XRD, AFM, and TEM studies. The optical transmission spectra showed that the films were highly transparent in the visible region of the spectrum and absorbed IR radiation at long and medium wavelengths