Incidence of neoplasms in dermatovenerology

The article considers the structure of the frequency of neoplasms in doctor-dermatovenerologist’s practice. The significance of these neoplasms is determined. Significance of these neoplasms determined.В статье изложена структура частоты встречаемости новообразований кожи в практике врача-дерматовенеролога. Определена значимость данных новообразований

Использование нанодисперсий, полученных из экстракта бересты, для солюбилизации плохо растворимых в воде веществ.

The method of poor soluble substances solubilization with the use of nanodispersions prepared from birch bark extract is proposed. Optimal substance/carrier ratios for methylpheophorbide A, doxorubicin, silymarin and silibinin have been determined.Предложен способ солюбилизации плохо растворимых субстанций с помощью нанодисперсий, полученных из тритерпеноидов бересты. Определены оптимальные соотношения субстанция/носитель для метилфеофорбида А, доксорубицина, силибинина и силимарина

Modern opportunities in cosmetology at regional clinic

Investigated the activity of the regional polyclinics “Dermatovenereology and cosmetology”. Established that the main nosological skin and subcutaneous tissue pathology is acne, papillomas, warts. Among the common cosmetology, dermatocosmetology is 12.1%, which emphasizes the need for further study and implementation of new organizational solutions in the activities of the cosmetology clinic

The use of nanodispersions prepared from birch bark extract for poor soluble substances solubilization.

The method of poor soluble substances solubilization with the use of nanodispersions prepared from birch bark extract is proposed. Optimal substance/carrier ratios for methylpheophorbide A, doxorubicin, silymarin and silibinin have been determined

Diagnostic score of malignancy risk in the people having a node in thyroid gland (Petrov Thyroid Cancer Score, PTCS)

A method for assessing the likelihood of finding a differentiated thyroid cancer based on the use of the Petrov Thyroid Cancer Score (PTCS) is proposed. The individual components of the score are divided into 4 groups in terms of their diagnostic significance. PTCS reflects  the opinions of specialists working in the different areas of oncology and needs further approbation based on retro- and prospective studie

Agronomic and Economic Aspects of Biodiesel Production from Oilseeds: A Case Study in Russia, Middle Volga Region

Emissions from fossil fuels are expected to increase in accordance with the global economy, which causes the development of alternative non-hydrocarbon sources in energy production. Biodiesel is one of the best options, among other sources, due to its low footprint. Russia does not have a smart policy of state support for biofuel production. The work objective was to determine whether it is necessary to develop equipment for biodiesel production, taking into account the structure of cultivated areas and available technologies; to calculate economic indicators of biodiesel production for agricultural needs; to compare the options for spring rape cultivation; as well as calculate the government support optimal level. As research methods, the authors used the apparatus of economic and mathematical modeling, and the method of absolute, relative and average values. Statistical tables are used to present the research results. Based on our study results, it is proven that the homemade biodiesel production by agricultural enterprises is economically justified. The equipment needed for its production was determined, the main economic indicators of the fuel production type and the optimal value of monetary and labor costs were calculated, and the gross and market biofuel values were obtained. The optimum level of government support for biofuel production in the Middle Volga region should be EUR 13.223 million, and the area planted with oil crops should be increased by 47.1 thousand ha

Peptidoglycan-Free Bacterial Ghosts Confer Enhanced Protection against Yersinia pestis Infection

To develop a modern plague vaccine, we used hypo-endotoxic Yersinia pestis bacterial ghosts (BGs) with combinations of genes encoding the bacteriophage ɸX174 lysis-mediating protein E and/or holin-endolysin systems from λ or L-413C phages. Expression of the protein E gene resulted in the BGs that retained the shape of the original bacterium. Co-expression of this gene with genes coding for holin-endolysin system of the phage L-413C caused formation of structures resembling collapsed sacs. Such structures, which have lost their rigidity, were also formed as a result of the expression of only the L-413C holin-endolysin genes. A similar holin-endolysin system from phage λ containing mutated holin gene S and intact genes R-Rz coding for the endolysins caused generation of mixtures of BGs that had (i) practically preserved and (ii) completely lost their original rigidity. The addition of protein E to the work of this system shifted the equilibrium in the mixture towards the collapsed sacs. The collapse of the structure of BGs can be explained by endolysis of peptidoglycan sacculi. Immunizations of laboratory animals with the variants of BGs followed by infection with a wild-type Y. pestis strain showed that bacterial envelopes protected only cavies. BGs with maximally hydrolyzed peptidoglycan had a greater protectivity compared to BGs with a preserved peptidoglycan skeleton