How and when does personal life orientation predict well-being?

Abstract We examined the direct and indirect––as mediated by job satisfaction––effects of personal life orientation on life satisfaction. We also examined whether these direct and indirect associations differed between employees working onsite or remotely. Using data from 432 employees (152 working onsite and 280 working remotely), our results revealed that personal life orientation was positively related to life satisfaction and negatively related to job satisfaction. Moreover, both of these direct associations were stronger among onsite employees than among remote employees. As a result, the indirect effects of personal life orientation on life satisfaction were significantly mediated by job satisfaction among employees working onsite, but not among employees working remotely. This study thus reveals that working remotely may act as a double-edged sword by buffering the negative effects of personal life orientation on job satisfaction, but also by limiting the positive effects of personal life orientation on life satisfaction

On the nature, predictors, and outcomes of longitudinal work passion profiles

Abstract Based on the dualistic model of passion, this study relies on person-centered analyses to assess how harmonious passion and obsessive passion for work combine within specific profiles of employees. We also documented the stability of these profiles over time and their associations with theoretically relevant predictors and outcomes, among a sample of 442 employees who completed a questionnaire twice over a period of 3 months. Finally, we examined whether these associations differed as a function of working remotely or onsite. Four profiles were identified and found to be highly stable over time: harmonious passion dominant, obsessive passion dominant, mixed passion-average, and low passion. Work centrality, family orientation, and supervisor expectations regarding work-related messages were all found to be related to employees’ likelihood of membership into the profiles in a way that generally supported our hypotheses. Moreover, and as expected, the harmonious passion dominant profile was associated with the highest levels of work–family enrichment, family–work enrichment, and job and life satisfaction. Lastly, none of these associations differed among employees working onsite or remotely

Understanding the genetic complexity of puberty timing across the allele frequency spectrum

Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women, identifying 1,080 signals for age at menarche. Collectively, these explained 11% of trait variance in an independent sample. Women at the top and bottom 1% of polygenic risk exhibited ~11 and ~14-fold higher risks of delayed and precocious puberty, respectively. We identified several genes harboring rare loss-of-function variants in ~200,000 women, including variants in ZNF483, which abolished the impact of polygenic risk. Variant-to-gene mapping approaches and mouse gonadotropin-releasing hormone neuron RNA sequencing implicated 665 genes, including an uncharacterized G-protein-coupled receptor, GPR83, which amplified the signaling of MC3R, a key nutritional sensor. Shared signals with menopause timing at genes involved in DNA damage response suggest that the ovarian reserve might signal centrally to trigger puberty. We also highlight body size-dependent and independent mechanisms that potentially link reproductive timing to later life disease

Understanding the genetic complexity of puberty timing across the allele frequency spectrum

Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women, identifying 1,080 signals for age at menarche. Collectively, these explained 11% of trait variance in an independent sample. Women at the top and bottom 1% of polygenic risk exhibited ~11 and ~14-fold higher risks of delayed and precocious puberty, respectively. We identified several genes harboring rare loss-of-function variants in ~200,000 women, including variants in ZNF483, which abolished the impact of polygenic risk. Variant-to-gene mapping approaches and mouse gonadotropin-releasing hormone neuron RNA sequencing implicated 665 genes, including an uncharacterized G-protein-coupled receptor, GPR83, which amplified the signaling of MC3R, a key nutritional sensor. Shared signals with menopause timing at genes involved in DNA damage response suggest that the ovarian reserve might signal centrally to trigger puberty. We also highlight body size-dependent and independent mechanisms that potentially link reproductive timing to later life disease

Resonant Raman scattering in Ga(As, P) mediated by (localized exciton-LO phonon) complex

Resonance light scattering experiments in polar crystals at energies corresponding to Eex + nħωLO have suggested that dressed excitons are the relevant intermediate states. Configuration coordinate model is applied to calculate the resonance Raman spectrum (intensity of phonons lines as a function of incident frequency) of the mixed crystal GaAs 0.2P0.8 and compared with experimental results of Oueslati, Hirlimann and Balkanski (J. Physique 42 (1981) 1151-1156). This analysis gives coupling constants V1 and V2 of a localized exciton with the LO1 phonon and the LO2 phonon respectively : V1/ħωLO1 = 0.7 ± 0.2; V2/ ħωLO2 = 1.4 ± 0.3, and exciton energy E0 = 2.442 eV with its width γ = 0.030 eV.Dans les cristaux polaires, les expériences de diffusion résonnante de la lumière suggèrent que les excitons « dressés » sont les principaux états intermédiaires dans le processus de diffusion pour des énergies incidentes ħωi = Eex + nħωLO. Le spectre de résonance Raman (Intensité des Raies Raman en fonction de l'énergie incidente) du cristal mixte GaAs0,2P0,8 est calculé dans le cadre du modèle des coordonnées de configuration. La comparaison avec les résultats expérimentaux de Oueslati, Hirlimann et Balkanski (J. Physique 42 (1981) 1151-1156) donne les coefficients de couplage V1 et V2 de l'exciton localisé avec les phonons LO1 et LO2 respectivement : V1/ħω LO1 = 0,7 ± 0,2; V2/ħωLO2 = 1,4 ± 0,3, et l'énergie de l'exciton E0 = 2,442 eV ainsi que sa largeur γ = 0,030 eV