Primary calcified hydatid of spleen: a case report

Most splenic cysts are parasitic. Hydatid disease, a parasitic disease, isendemic in Kashmir. Splenic involvement alone in hydatid disease is very rare. It may remain asymptomatic or, by causing pressure due to increasing size on adjacent viscera, may become symptomatic. A non specific presentation always makes diagnosis difficult. A case of hydatid spleen in a young boy who presented with abdominal pain is reported. Radiology complemented with serology made the diagnosis. Hydatid disease should beconsidered as a differential diagnosis in every patient with a calcified cystic mass of the spleen in endemic areas.KEY WORDS: Calcified hydatid; Spleen; Splenic cyst; Case repor

Studies on Genetic Variability in Dolichos Bean (Lablab purpureus L.)

Fifty seven pole-type vegetable dolichos bean [Lablab purpureus (L.) Sweet] germplasm lines were evaluated for genetic variability, heritability and genetic advance at the experimental farm of Indian Institute of Horticultural Research, Bangalore, during 2010-12. GCV was comparatively high in days to 50% flowering, days to pod maturity, pod length, pod weight, number of pods per cluster, number of pods per plant, pod yield per plant and pod width. High heritability estimates were observed for number of pods per plant, pod yield per plant, pod weight, days to 50% flowering, pod length, days to pod maturity, pod width and number of pods per cluster. High genetic advance, along with relatively high heritability percent, was observed for number of pods per cluster and pod width. Existence of wide variation along with high heritability and genetic advance for number of pods per cluster, pod length, pod width and pod yield per plant indicate that selection would be effective for these traits. Among the accessions studied, IIHR 177 was early for 50% flowering (43 days) and pod maturity (65 days). IIHR 6 and IIHR 11 had maximum pod length (16.5cm) and pod width (4.1cm), respectively. Ten-pod weight was highest in IIHR 7(122g), while the number of pods per plant was high in IIHR 159 (91.0). Maximum pod yield was seen in IIHR 150 (576.9g per plant). These accessions having green, purple or creamy-white pods can be used in future breeding programmes

Effect of Sm3+ as co-dopant in CaSO4:Dy,P TLD phosphor

CaSO4: Dy,P  and CaSO4:Dy,P,Sm  thermoluminescence (TL) phosphors have been prepared by acid method and their TL glow curves and  photoluminescence (PL)  excitation and emission spectra are recorded. PL emission bands at 565, 599 and 613 nm were observed for CaSO4: Dy,P,Sm under the excitation wavelength 402 nm. Dosimetric peak is observed around 2460C at high temperature.  Co-doping of Sm3+ in CaSO4:Dy,P enhances its TL intensity by a factor of 1.11

Analysis and Simulations of Abnormalities for Induction Motor Using PSCAD

Induction motors are most important part of any network or industry because most of the industries rely on this to drive their equipment. Due to various faults that take place in the motor it interrupts the normal functioning of the motor and leads to system failure or loss. So, it is necessary to reduce this stress factors to a safer level for normal functioning of the motor and this can be done by using various types of protective devices. In this paper we have mentioned different types of abnormalities and how to analyse these abnormalities using PSCAD. By simulating we can know proper working of any system and how that system would behave if same configuration existing at that time during fault. DOI: 10.17762/ijritcc2321-8169.150513

Structure and Optical Properties of Self-Assembled Multicomponent Plasmonic Nanogels

Multicomponent plasmonic nanogels (PNGs) capable of broadband absorption of light in the 400-700 nm wavelength range were synthesized by the self-assembly of metal nanoparticles with wormlike surfactant micelles. Small angle x-ray scattering and rheological experiments suggest that the nanoparticles bridge micelle fragments to aid the formation a stable gel phase with exceptional color uniformity. Their optical absorbance could be robustly tuned by changing the nanoparticle type (Au/Ag), size, shape, and/or concentration. The PNGs have relatively low viscosity and are thermoreversible. Potential applications to the manufacturing of coatings and interfaces for solar energy harvesting and reconfigurable optical devices can be envisioned

FORMULATION, DEVELOPMENT AND CHARACTERIZATION OF DRUG DELIVERY SYSTEMS BASED TELMISARTAN ENCAPSULATED IN SILK FIBROIN NANOSPHERE’S

Objective: The aim of the present work was to formulate silk fibroin (SF) nanospheres (NS’s) for drug delivery application. The current study was designed to advance the water solubility and bio-availability of telmisartan by nanoprecipitation method. Methods: SF NS’s loaded with TS were prepared by nanoprecipitation method. The drug was dissolved in aqueous solution of SF by using acetone as a non-solvent. The prepared NS’s were then characterized by FTIR, X-ray diffraction and zeta potential, and were evaluated for its, surface morphology, %drug content, encapsulation efficiency and in vitro drug release. Results: The evaluation results of SF NS’s loaded of TS showed 74.22±0.17 % entrapment efficiency, 35.21±0.02 % of drug loading, and-4.9 mV to-13.6 mV of zeta potential due to the proper bounding of TS with the β-sheets of SF, the particle size reported was within the size range of 160-186 nm having smooth surface and were spherical in shape. The SFNS’s pattern switched from random coil to β-sheet formation on treating with acetone. FTIR and DSC studies marked no such inter-molecular interactions between SF and drug molecules. The % cumulative in vitro drug release from SF NS’s exhibited quick burst release. The in vitro cumulative drug release of SF NS’s of TS it was found that about 74% of the drug was released within 8 h and about 96% of drug released at 24 hr. The rate of drug release increased with the increase in SF ratio. Conclusion: It is believed that these SF NS’s will find potential applications in drug delivery release as drug carriers, especially poor water-soluble drugs. All these results proposed that SF NS’s are eventuality handy in various drug delivery systems

Garden Pea Improvement in India

Garden pea (Pisum sativum L. var. hortense) is an important legume vegetable grown for its fresh, shelled green seeds rich in proteins, vitamins and minerals. At present over 1000 germplasm lines are available in India. Improvement of garden pea in the country was initiated during the 1940s in IARI and later in several other agricultural universities/ ICAR institutes. Currently, 27 early-varieties and 59 mid-season varieties are under cultivation in india. Initially, focus was on developing early-maturing varieties with high yield and quality. Subsequently, emphasis was laid on developing mid-season varieties having resistance to powdery mildew and other major diseases like Fusarium wilt and rust. Besides, varieties with resistance to bruchids and the leaf miner are also available. In the present paper, an attempt has been made to review current status of improvement of garden pea in India, covering its genetic resources, variability, heritability, genetic advance, heterosis and combining ability, G x E interaction, male sterility, breeding for biotic and abiotic stresses, mutation breeding and biotechnological applications. In recent years, there has been an increase in demand for varieties suited to kharif and early summer seasons, with resistance to powdery mildew, rust, Fusarium root wilt/rot and stemfly and also for processing and export. Therefore, future thrust in the improvement of garden pea would be on developing varieties tolerant to biotic and abiotic stresses (mainly high temperature), and also for processing and export

A prospective comparative study of Lichtenstein procedure with and without mesh-fixation for inguinal hernia repair

Background: Repair of inguinal hernia is one of the most common elective operations performed in general surgery worldwide. Mesh-hernioplasty became the gold standard, because of its low recurrence rate in comparison with tissue repairs. The ideal repair must be simple, safe, easy to perform and require minimal dissection which provides enough space, should be cost effective with less hospital stay, less pain and less recurrence. The present study aimed at comparing the effect of mesh fixation and non-fixation in Lichtenstein technique for inguinal hernia repair.Methods: Hundred (100) patients with primary uncomplicated, unilateral inguinal hernia were treated between April 2019 and September 2020. Patients with inguinal hernia underwent Lichtenstein repair with mesh-fixation (group A) (n=50) and non-fixation (group B) (n=50). The mean operative time, post-operative pain score, average hospital study, post-operative complications and recurrence rates were compared between the two groups.Results: Mean operative time in non-fixation group- (group B) (32.24 min) was shorter as compared to fixation group-(Group A) (49.36 min) with a p value of 0.002. Post-operative pain score was lower in (group B) at 12 and 24 hours (3.71±1.409 and 2.2±0.8169) as compared to Group A at 12 and 24 hours (4.77±1.196 and 2.98±1.295) with a p value of <0.0001. The analgesia required in (group B) was less as compared to (group A). The post-operative complication and recurrence rates were almost identical in both the groups, with lesser incidence of groin pain and paresthesias in group B.Conclusions: In Lichtenstein inguinal hernia repair, non-fixation of mesh is safe and preferable option, with less operative time and less postoperative pain

Nuclear-mitochondrial genomic profiling reveals a pattern of evolution in epithelial ovarian tumor stem cells

Analyses of genome orthologs in cancer on the background of tumor heterogeneity, coupled with the recent identification that the tumor propagating capacity resides within a very small fraction of cells (the tumor stem cells-TSCs), has not been achieved. Here, we describe a strategy to explore genetic drift in the mitochondrial genome accompanying varying stem cell dynamics in epithelial ovarian cancer. A major and novel outcome is the identification of a specific mutant mitochondrial DNA profile associated with the TSC lineage that is drastically different from the germ line profile. This profile, however, is often camouflaged in the primary tumor, and sometimes may not be detected even after metastases, questioning the validity of whole tumor profiling towards determining individual prognosis. Continuing mutagenesis in subsets with a mutant mitochondrial genome could result in transformation through a cooperative effect with nuclear genes - a representative example in our study is a tumor suppressor gene viz. cAMP responsive element binding binding protein. This specific profile could be a critical predisposing step undertaken by a normal stem cell to overcome a tightly regulated mutation rate and DNA repair in its evolution towards tumorigenesis. Our findings suggest that varying stem cell dynamics and mutagenesis define TSC progression that may clinically translate into increasing tumor aggression with serious implications for prognosis

Plasmonic Nanogels with Robustly Tunable Optical Properties

Low viscosity fluids with tunable optical properties can be processed to manufacture thin film and interfaces for molecular detection, light trapping in photovoltaics and reconfigurable optofluidic devices. In this work, self-assembly in wormlike micelle solutions is used to uniformly distribute various metallic nanoparticles to produce stable suspensions with localized, multiple wavelength or broad-band optical properties. Their spectral response can be robustly modified by varying the species, concentration, size and/or shape of the nanoparticles. Structure, rheology and optical properties of these plasmonic nanogels as well as their potential applications to efficient photovoltaics design are discussed