281 research outputs found
Automorphism Groups of Graphical Models and Lifted Variational Inference
Using the theory of group action, we first introduce the concept of the
automorphism group of an exponential family or a graphical model, thus
formalizing the general notion of symmetry of a probabilistic model. This
automorphism group provides a precise mathematical framework for lifted
inference in the general exponential family. Its group action partitions the
set of random variables and feature functions into equivalent classes (called
orbits) having identical marginals and expectations. Then the inference problem
is effectively reduced to that of computing marginals or expectations for each
class, thus avoiding the need to deal with each individual variable or feature.
We demonstrate the usefulness of this general framework in lifting two classes
of variational approximation for MAP inference: local LP relaxation and local
LP relaxation with cycle constraints; the latter yields the first lifted
inference that operate on a bound tighter than local constraints. Initial
experimental results demonstrate that lifted MAP inference with cycle
constraints achieved the state of the art performance, obtaining much better
objective function values than local approximation while remaining relatively
efficient.Comment: Extended version of the paper to appear in Statistical Relational AI
(StaRAI-12) workshop at UAI '1
A Bacterial Toxin Inhibits DNA Replication Elongation through a Direct Interaction with the Ξ² Sliding Clamp
Toxin-antitoxin (TA) systems are ubiquitous on bacterial chromosomes, yet the mechanisms regulating their activity and the molecular targets of toxins remain incompletely defined. Here, we identify SocAB, an atypical TA system in Caulobacter crescentus. Unlike canonical TA systems, the toxin SocB is unstable and constitutively degraded by the protease ClpXP; this degradation requires the antitoxin, SocA, as a proteolytic adaptor. We find that the toxin, SocB, blocks replication elongation through an interaction with the sliding clamp, driving replication fork collapse. Mutations that suppress SocB toxicity map to either the hydrophobic cleft on the clamp that binds DNA polymerase III or a clamp-binding motif in SocB. Our findings suggest that SocB disrupts replication by outcompeting other clamp-binding proteins. Collectively, our results expand the diversity of mechanisms employed by TA systems to regulate toxin activity and inhibit bacterial growth, and they suggest that inhibiting clamp function may be a generalizable antibacterial strategy.Howard Hughes Medical Institute (Summer Medical Fellowship)National Science Foundation (U.S.). Graduate Research Fellowship ProgramNational Institutes of Health (U.S.) (R01GM082899
Petrographic Characteristics and Depositional Environment Evolution of Middle Miocene Sediments in the Thien Ung - Mang Cau Structure of Nam Con Son Basin
This paper introduces the petrographic characteristics and depositional environment of Middle Miocene rocks of the Thien Ung - Mang Cau structure in the central area of Nam Con Son Basin based on the results of analyzing thin sections and structural characteristics of core samples. Middle Miocene sedimentary rocks in the studied area can be divided into three groups: (1) Group of terrigenous rocks comprising greywacke sandstone, arkosic sandstone, lithic-quartz sandstone, greywacke-lithic sandstone, oligomictic siltstone, and bitumenous claystone; (2) Group of carbonate rocks comprising dolomitic limestone and bituminous limestone; (3) Mixed group comprising calcareous sandstone, calcarinate sandstone, arenaceous limestone, calcareous claystone, calcareous silty claystone, dolomitic limestone containing silt, and bitumen. The depositional environment is expressed through petrographic characteristics and structure of the sedimentary rocks in core samples. The greywacke and arkosic sandstones are of medium grain size, poor sorting and roundness, and siliceous cement characterizing the alluvial and estuarine fan environment expressed by massive structure of core samples. The mixed calcareous limestone, arenaceous dolomitic limestone, and calcareous and bituminous clayey siltstone in the core samples are of turbulent flow structure characterizing shallow bay environment with the action of bottom currents. The dolomitic limestones are of relatively homogeneous, of microgranular and fine-granular texture, precipitated in a weakly reducing, semi-closed, and relatively calm bay environment
CONTAMINATION BY ARSENIC AND LEAD IN RESIDENTS FROM VIETNAM
Joint Research on Environmental Science and Technology for the Eart
A case of hepatic cyst-induced internal jugular venous thrombosis
β’ Echocardiography can demonstrate hepatic cystβinduced right atrial compression. β’ Hepatic cystβinduced blood flow stasis can cause internal jugular venous thrombus. β’ Laparoscopic deroofing of hepatic cysts is a safe and effective treatment
ΠΠ΅ΡΠΎΠ΄ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π΄ΠΈΠ°Π±Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠΈΠ½ΠΎΠΏΠ°ΡΠΈΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π°Π½Π°Π»ΠΈΠ·Π° ΠΈΠ·ΠΎΠ±ΡΠ°ΠΆΠ΅Π½ΠΈΠΉ Π³Π»Π°Π·Π½ΠΎΠ³ΠΎ Π΄Π½Π°
Introduction. Diabetic retinopathy is a complication of diabetes mellitus caused by high blood sugar levels damaging the retina. Diabetic retinopathy leads to changes in ocular blood vessels and the appearance of solid exudates and microaneurysms. When diagnosed and treated in the late stages, this disease can cause blindness. The most common diagnostic method for diabetic retinopathy is based on ocular fundus imaging. However, the background interference and low contrast of such images significantly hinders the timely detection of vascular lesions. Therefore, the development of a method for detecting signs of diabetic retinopathy, particularly in its early stages, presents a relevant research task.Aim. Development of a method for diagnosing diabetic retinopathy based on an analysis of ocular fundus images using the decision-tree approach.Materials and methods. Methods based on image segmentation with identifying characteristic features and their binary classification were used. A verified database was used to access the accuracy of the proposed method for detecting diabetic retinopathy.Results. A method for detecting signs of diabetic retinopathy was developed, which includes the segmentation of vessels, exudates and microaneurysms based on digital processing of ocular vascular images using binary classification. The developed method showed a high level of diagnostic accuracy. Thus, the sensitivity, specificity and accuracy of diabetic retinopathy detection comprised 87.14, 88.50 and 87.81 %, respectively.Conclusion. The developed method allows diabetic retinopathy to be diagnosed with sufficiently high accuracy. The method can also be used for supporting decision making when managing patients with diabetic retinopathy.ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅. ΠΠΈΠ°Π±Π΅ΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠ΅ΡΠΈΠ½ΠΎΠΏΠ°ΡΠΈΡ β ΡΡΠΎ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠ΅ ΡΠ΅ΡΡΠ°ΡΠΊΠΈ Π³Π»Π°Π·Π° ΠΏΡΠΈ ΡΠ°Ρ
Π°ΡΠ½ΠΎΠΌ Π΄ΠΈΠ°Π±Π΅ΡΠ΅ Π²ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ Π²ΡΡΠΎΠΊΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ ΡΠ°Ρ
Π°ΡΠ° Π² ΠΊΡΠΎΠ²ΠΈ. ΠΡΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ ΠΌΠΎΠΆΠ΅Ρ ΠΏΡΠΈΠ²Π΅ΡΡΠΈ ΠΊ ΡΠ»Π΅ΠΏΠΎΡΠ΅, Π΅ΡΠ»ΠΈ Π±ΠΎΠ»Π΅Π·Π½Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΡΠ΅ΡΡΡ ΠΈ Π»Π΅ΡΠΈΡΡΡ Π½Π° ΠΏΠΎΠ·Π΄Π½ΠΈΡ
ΡΡΠ°Π΄ΠΈΡΡ
ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ. ΠΠ½ΠΎ Π²ΡΠ·ΡΠ²Π°Π΅Ρ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΡΠΎΠ²Π΅Π½ΠΎΡΠ½ΡΡ
ΡΠΎΡΡΠ΄ΠΎΠ² ΠΈ ΠΏΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ
ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ, ΡΠ°ΠΊΠΈΡ
, ΠΊΠ°ΠΊ ΡΠ²Π΅ΡΠ΄ΡΠ΅ ΡΠΊΡΡΡΠ΄Π°ΡΡ ΠΈ ΠΌΠΈΠΊΡΠΎΠ°Π½Π΅Π²ΡΠΈΠ·ΠΌΡ. ΠΠ»Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π΄ΠΈΠ°Π±Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠΈΠ½ΠΎΠΏΠ°ΡΠΈΠΈ ΡΠ°ΡΡΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΡΡΡ ΠΌΠ΅ΡΠΎΠ΄ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠΎΡΡΠ΄ΠΈΡΡΡΡ
ΡΡΡΡΠΊΡΡΡ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΈΠ·ΠΎΠ±ΡΠ°ΠΆΠ΅Π½ΠΈΠΉ Π³Π»Π°Π·Π½ΠΎΠ³ΠΎ Π΄Π½Π°. ΠΠ΄Π½Π°ΠΊΠΎ Π΄Π°ΠΆΠ΅ Π²ΡΠ°ΡΠΈ-ΠΎΡΡΠ°Π»ΡΠΌΠΎΠ»ΠΎΠ³ΠΈ Π½Π΅ ΠΌΠΎΠ³ΡΡ ΠΎΠ±Π½Π°ΡΡΠΆΠΈΡΡ ΡΡΠΈ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΠΈΠ·-Π·Π° ΡΠΎΠ½ΠΎΠ²ΡΡ
ΠΏΠΎΠΌΠ΅Ρ
ΠΈ ΠΈΡ
Π½ΠΈΠ·ΠΊΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΡΠ°ΡΡΠ°, Π²ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ ΡΠ΅Π³ΠΎ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΠΌΠ΅ΡΠΎΠ΄Π° Π΄Π»Ρ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ² Π΄ΠΈΠ°Π±Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠΈΠ½ΠΎΠΏΠ°ΡΠΈΠΈ, Π² ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π½Π° ΡΠ°Π½Π½ΠΈΡ
ΡΡΠ°Π΄ΠΈΡΡ
, ΡΠ²Π»ΡΠ΅ΡΡΡ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΠΉ.Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ. Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΠΌΠ΅ΡΠΎΠ΄Π° Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π΄ΠΈΠ°Π±Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠΈΠ½ΠΎΠΏΠ°ΡΠΈΠΈ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π΄Π΅ΡΠ΅Π²Π° ΡΠ΅ΡΠ΅Π½ΠΈΠΉ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΈΠ·ΠΎΠ±ΡΠ°ΠΆΠ΅Π½ΠΈΠΉ Π³Π»Π°Π·Π½ΠΎΠ³ΠΎ Π΄Π½Π°. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΈΠΌΠ΅Π½Π΅Π½Ρ ΠΌΠ΅ΡΠΎΠ΄Ρ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠ΅Π³ΠΌΠ΅Π½ΡΠ°ΡΠΈΠΈ ΠΈΠ·ΠΎΠ±ΡΠ°ΠΆΠ΅Π½ΠΈΠΉ Ρ Π²ΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ΠΌ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΡΡ
ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ² ΠΈ Π±ΠΈΠ½Π°ΡΠ½ΠΎΠΉ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ. ΠΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΡΡΡ Π²Π΅ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½Π°Ρ Π±Π°Π·Π° Π΄Π°Π½Π½ΡΡ
Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠΎΡΠ½ΠΎΡΡΠΈ ΠΌΠ΅ΡΠΎΠ΄Π° Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π΄ΠΈΠ°Π±Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠΈΠ½ΠΎΠΏΠ°ΡΠΈΠΈ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½ Π°Π»Π³ΠΎΡΠΈΡΠΌ, Π²ΠΊΠ»ΡΡΠ°ΡΡΠΈΠΉ ΠΌΠ΅ΡΠΎΠ΄Ρ ΡΠ΅Π³ΠΌΠ΅Π½ΡΠ°ΡΠΈΠΈ ΡΠΎΡΡΠ΄ΠΎΠ², ΡΠΊΡΡΡΠ΄Π°ΡΠΎΠ² ΠΈ ΠΌΠΈΠΊΡΠΎΠ°Π½Π΅Π²ΡΠΈΠ·ΠΌ Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π΄ΠΈΠ°Π±Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠΈΠ½ΠΎΠΏΠ°ΡΠΈΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠΈΡΡΠΎΠ²ΠΎΠΉ ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΈΠ·ΠΎΠ±ΡΠ°ΠΆΠ΅Π½ΠΈΠΉ ΡΡΡΡΠΊΡΡΡΡ ΡΡΠ΅Π½ΠΎΠΊ ΠΊΡΠΎΠ²Π΅Π½ΠΎΡΠ½ΡΡ
ΡΠΎΡΡΠ΄ΠΎΠ² Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π±ΠΈΠ½Π°ΡΠ½ΠΎΠΉ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ. ΠΠΎΠ»ΡΡΠ΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Ρ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΠΎΡΠ½ΠΎΡΡΡΡ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ Π΄ΠΈΠ°Π±Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠΈΠ½ΠΎΠΏΠ°ΡΠΈΠΈ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π²Π΅ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π±Π°Π·Ρ ΠΈΠ·ΠΎΠ±ΡΠ°ΠΆΠ΅Π½ΠΈΠΉ Π³Π»Π°Π·Π½ΠΎΠ³ΠΎ Π΄Π½Π°. Π§ΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ, ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡ ΠΈ ΡΠΎΡΠ½ΠΎΡΡΡ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ Π΄ΠΈΠ°Π±Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠΈΠ½ΠΎΠΏΠ°ΡΠΈΠΈ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ 87.14, 88.50 ΠΈ 87.81 %.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΎΠ±Π½Π°ΡΡΠΆΠΈΠ²Π°ΡΡ Π΄ΠΈΠ°Π±Π΅ΡΠΈΡΠ΅ΡΠΊΡΡ ΡΠ΅ΡΠΈΠ½ΠΎΠΏΠ°ΡΠΈΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π½Π° ΡΠ°Π½Π½ΠΈΡ
ΡΡΠ°Π΄ΠΈΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Ρ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΠΎΡΠ½ΠΎΡΡΡΡ. ΠΠ΅ΡΠΎΠ΄ ΡΠ°ΠΊΠΆΠ΅ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΠΈ Π²ΡΠ°ΡΠ° Π΄Π»Ρ ΠΏΡΠΈΠ½ΡΡΠΈΡ ΡΠ΅ΡΠ΅Π½ΠΈΠΉ ΠΏΡΠΈ Π΄ΠΈΠ°Π±Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠΈΠ½ΠΎΠΏΠ°ΡΠΈΠΈ
Paediatrician\u27s guide to post-operative care for functionally univentricular CHD: A review
IMPORTANCE: Single ventricle CHD affects about 5 out of 100,000 newborns, resulting in complex anatomy often requiring multiple, staged palliative surgeries. Paediatricians are an essential part of the team that cares for children with single ventricle CHD. These patients often encounter their paediatrician first when a complication arises, so it is critical to ensure the paediatrician is knowledgeable of these issues to provide optimal care.
OBSERVATIONS: We reviewed the subtypes of single ventricle heart disease and the various palliative surgeries these patients undergo. We then searched the literature to detail the general paediatrician\u27s approach to single ventricle patients at different stages of surgical palliation.
CONCLUSIONS AND RELEVANCE: Single ventricle patients undergo staged palliation that drastically changes physiology after each intervention. Coordinated care between their paediatrician and cardiologist is requisite to provide excellent care. This review highlights what to expect when these patients are seen by their paediatrician for either well child visits or additional visits for parental or patient concern
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