Thermal noise in half infinite mirrors with non-uniform loss: a slab of excess loss in a half infinite mirror

We calculate the thermal noise in half-infinite mirrors containing a layer of arbitrary thickness and depth made of excessively lossy material but with the same elastic material properties as the substrate. For the special case of a thin lossy layer on the surface of the mirror, the excess noise scales as the ratio of the coating loss to the substrate loss and as the ratio of the coating thickness to the laser beam spot size. Assuming a silica substrate with a loss function of 3x10-8 the coating loss must be less than 3x10-5 for a 6 cm spot size and a 7 micrometers thick coating to avoid increasing the spectral density of displacement noise by more than 10%. A similar number is obtained for sapphire test masses.Comment: Passed LSC (internal) review. Submitted to Phys. Rev. D. (5/2001) Replacement: Minor typo in Eq. 17 correcte

Thermal noise in interferometric gravitational wave detectors due to dielectric optical coatings

We report on thermal noise from the internal friction of dielectric coatings made from alternating layers of Ta2O5 and SiO2 deposited on fused silica substrates. We present calculations of the thermal noise in gravitational wave interferometers due to optical coatings, when the material properties of the coating are different from those of the substrate and the mechanical loss angle in the coating is anisotropic. The loss angle in the coatings for strains parallel to the substrate surface was determined from ringdown experiments. We measured the mechanical quality factor of three fused silica samples with coatings deposited on them. The loss angle of the coating material for strains parallel to the coated surface was found to be (4.2 +- 0.3)*10^(-4) for coatings deposited on commercially polished slides and (1.0 +- 0.3)*10^{-4} for a coating deposited on a superpolished disk. Using these numbers, we estimate the effect of coatings on thermal noise in the initial LIGO and advanced LIGO interferometers. We also find that the corresponding prediction for thermal noise in the 40 m LIGO prototype at Caltech is consistent with the noise data. These results are complemented by results for a different type of coating, presented in a companion paper.Comment: Submitted to LSC (internal) review Sept. 20, 2001. To be submitted to Phys. Lett.

The LonDownS adult cognitive assessment to study cognitive abilities and decline in Down syndrome [version 1; referees: awaiting peer review].

BACKGROUND: Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with an ultra-high risk of developing Alzheimer’s disease. However, there is individual variability in the onset of clinical dementia and in baseline cognitive abilities prior to decline, particularly in memory, executive functioning, and motor coordination. The LonDownS Consortium aims to determine risk and protective factors for the development of dementia and factors relating to cognitive abilities in people with DS. Here we describe our cognitive test battery and related informant measures along with reporting data from our baseline cognitive and informant assessments. METHODS: We developed a cognitive test battery to assess general abilities, memory, executive function, and motor coordination abilities in adults with DS, with informant ratings of similar domains also collected, designed to allow for data on a broad range of participants. Participants (n=305) had a range of ages and abilities, and included adults with and without a clinical diagnosis of dementia. RESULTS: Results suggest the battery is suitable for the majority of adults with DS, although approximately half the adults with dementia were unable to undertake any cognitive task. Many test outcomes showed a range of scores with low floor and ceiling effects. Non-verbal age-adjusted IQ scores had lower floor effects than verbal IQ scores. Before the onset of any cognitive decline, females aged 16-35 showed better verbal abilities compared to males. We also identified clusters of cognitive test scores within our battery related to visuospatial memory, motor coordination, language abilities, and processing speed / sustained attention. CONCLUSIONS: Our further studies will use baseline and longitudinal assessments to explore factors influencing cognitive abilities and cognitive decline related to ageing and onset of dementia in adults with DS

Fluoxetine reverses the memory impairment and reduction in proliferation and survival of hippocampal cells caused by methotrexate chemotherapy

RATIONALE: Adjuvant cancer chemotherapy can cause long-lasting, cognitive deficits. It is postulated that these impairments are due to these drugs targeting neural precursors within the adult hippocampus, the loss of which has been associated with memory impairment. OBJECTIVES: The present study investigates the effects of the chemotherapy, methotrexate (MTX) on spatial working memory and the proliferation and survival of the neural precursors involved in hippocampal neurogenesis, and the possible neuroprotective properties of the antidepressant fluoxetine. METHODS: Male Lister hooded rats were administered MTX (75 mg/kg, two i.v. doses a week apart) followed by leucovorin rescue (i.p. 18 h after MTX at 6 mg/kg and at 26, 42 and 50 h at 3 mg/kg) and/or fluoxetine (10 mg/kg/day in drinking water for 40 days). Memory was tested using the novel location recognition (NLR) test. Using markers, cell proliferation (Ki67) and survival (bromodeoxyuridine/BrdU), in the dentate gyrus were quantified. RESULTS: MTX-treated rats showed a cognitive deficit in the NLR task compared with the vehicle and fluoxetine-treated groups. Cognitive ability was restored in the group receiving both MTX and fluoxetine. MTX reduced both the number of proliferating cells in the SGZ and their survival. This was prevented by the co-administration of fluoxetine, which alone increased cell numbers. CONCLUSIONS: These results demonstrate that MTX induces an impairment in spatial working memory and has a negative long-term effect on hippocampal neurogenesis, which is counteracted by the co-administration of fluoxetine. If translatable to patients, this finding has the potential to prevent the chemotherapy-induced cognitive deficits experienced by many cancer survivors

From the margins to the mainstream: The evolution of the debate surrounding UK membership of the EU

Stephen George famously labeled the UK as the ‘awkward partner’ when analyzing the country’s relationship with the EU. The ‘permissive consensus’ evident in most EU nation states - at least prior to the Eurozone crisis - was never as clear-cut in the British Isles. However, recent developments have propelled the issue of UK membership to the centre-stage of British politics, serving to galvanize those on the side of the Eurosceptic debate. By analyzing factors such as the Conservative party’s splits over ‘Europe’, the rise of the UK Independence party (UKIP), Prime-Minister Cameron’s promise of a referendum on EU membership and the role and influence of the UK media, the purpose of the paper is to demonstrate how the debate surrounding UK membership of the EU has now completed its journey from the margins to the mainstream of British politics. It concludes with a discussion of the potential consequences of thisdevelopmen

Euroscepticism as a Persistent Phenomenon

In the two decades since the emergence of the European Union at Maastricht there has been a concerted attempt to build a European political space, typified by the debates on constitutionalization and democratization. Much less noticed, but no less important, has been the mobilization of publics, interest groups and political parties against the integration process. In the light of the failure to realize the Laeken objectives, the stabilization of an anti-integration bloc in the European Parliament, recurrent ‘no’ votes in national referendums and the emergence of an increasingly co-ordinated movement of critical interest groups, it is argued in this article that this opposition has become embedded and persistent, at both European and national levels. This will have considerable consequences for the Union itself and the way it has chosen to largely ignore sceptical voices to date

Does the information source matter? Newspaper readership, political preferences and attitudes towards the European Union in the United Kingdom, France and the Netherlands

Previous research has indicated that political radicals and cynics tend to obtain information from like-minded media sources. In this study, we relate media use to political preferences by utilising a cross-national large-N data set collected during the European elections in 2014 through an online opt-in sample and the European Election Studies (EES), in order to test whether individuals who are negatively opinionated towards the EU and the political elite get informed via media that have a similar attitude towards the EU and politics. Our findings indicate that Eurosceptic voters differ considerably from moderate and pro-European voters in terms of their daily media use. In addition, we find that getting informed via a left-wing- or a right-wing-oriented mainstream media matters, when explaining voter’s policy preference

Concentration changes for 5 PCDD/F congeners after administration in beef cattle

Ten cattle were treated with daily doses of five PCDD/F congeners, over a 4 week period. Four control animals were not treated. They were subsequently slaughtered as three groups, at 5, 18 and 31 weeks after the first dose. All congeners showed an increase in concentration within animal tissues when sampled at 5 weeks post-dosing. Concentrations had reduced after 18 weeks and there was a further small reduction after 31 weeks. Halflives for each congener were calculated at 13–21 weeks (93–148 days). Concentrations of congeners were different in the various tissues analysed. At 5 weeks after dosing commenced, concentrations in sub-cutaneous fat and in perirenal fat were close to 40 ng/kg (a predicted level based on 50% absorption of the dosed compounds). Concentrations on a fat basis in muscle tissue and liver were, however, about 5 and 10 times higher, respectively. The concentrations found in muscle tissue and liver samples taken at 18 and 31 weeks were approximately twice that found in fat deposits, thus the differences were still apparent, but at a reduced level. It is possible that the distribution phase was incomplete and that PCDD/Fs remained predominantly in association with circulating blood lipids rather than in equilibrium with depot fat. It follows that if livestock were recently exposed to PCDD/Fs (for example, through the consumption of contaminated feed), the analysis of depot fats would not necessarily provide a reliable indicator of the concentrations of PCDD/Fs in edible tissues