DEVELOPMENT OF NITROFURAN DERIVATIVE: COMPOSITION AND TECHNOLOGY OF EFFERVESCENT TABLETS WITH SOLID DISPERSIONS

Taking into account the current Product specification file, the aim of the work was to develop the composition and technology for obtaining effervescent tablets based on solid dispersions of furazolidone in the form of an aqueous solution for external use.Materials and methods. The used substances were: furazolidone, anhydrous sodium carbonate (chemically pure), polyvinylpyrrolidone-24000±2000 (chemically pure), malic acid (analytically pure), tartaric acid (chemically pure), citric acid (chemically pure), sodium benzoate (chemically pure), ethyl alcohol 96% (chemically pure), purified water. Preparation of granulates is separate wet granulation in a fluidized bed (Mycrolab, BOSCH, Germany). Obtaining tablets is the process of pressing on a manual hydraulic test press ("PRG", VNIR, Russia). The dependence of disintegration, abrasion capacity and crushing resistance on compacting pressure was investigated. Technological parameters of granulates, еру obtained effervescent tablets, shelf life and storage conditions were investigated according to the State Pharmacopoeia of the Russian Federation XIVth ed.Results. Two compositions of effervescent tablets containing solid dispersions of furazolidone as an active substance were obtained, which, when dissolved in 100 ml of water at room temperature (20°C), form a solution of furazolidone with a concentration of 0.004% in less than 5 minutes. The method of quantitative determination of the furazolidone content in the effervescent tablets was validated. A complex of physicochemical methods for the analysis of tablets was carried out. Quality standards have been developed. The developed compositions stability of instant tablets during storage during accelerated and long-term tests has been experimentally confirmed. The preliminary shelf life and storage conditions have been determined.Conclusion. The result of technological and chemical-pharmaceutical research is the creation and evaluation of the quality of a new instant furazolidone dosage form as effervescent tablet formulations

Digital traceability: concept and directions of development

Актуальность проведенного исследования обусловлена влиянием мировых интеграционных процессов на национальные экономики. Цифровая прослеживаемость перемещаемых товаров является одним из действенных направлений решения проблемы с контрафактной продукцией. Целью данного исследования является обоснование целесообразности формирования инфраструктуры цифровой прослеживаемости на государственном и межгосударственном уровнях в условиях формирования единого информационного пространства. The relevance of the study is due to the influence of world integration processes on national economies. Digital traceability of goods in transit is one of the most effective ways to solve the problem of counterfeit products. The purpose of this study is to substantiate the feasibility of forming a digital traceability infrastructure at the state and interstate levels in the context of forming a single information space

Methodology of e-economy infrastructure research

This paper aims to clarify the meaning of the term ‘infrastructure’ from the standpoint of the development of economic system of new quality – e-economy. It describes the testing results of the methodology proposed for the infrastructure of e-economy analyses. Framework such as construction of e-economy infrastructure index has been proposed. This framework provided guidelines, which were subsequently used to perform a comparative analyses of the components of e-economy infrastructure for countries with medium level of e-economy development