A REVIEW ON DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPLC METHODS FOR ANALYSIS OF ACIDIC DRUGS

High-performance liquid chromatography is one of the fastest, safest and precise technology used for determination and separation of pharmaceutical drugs, impurities and biological samples. High-performance liquid chromatography is versatile and it takes less time for quantification of drugs as compared to old liquid chromatography techniques. This article reviews stability indicating HPLC method developed and validated for acidic drugs and their degradation studies

Visualizing aerosol-particle injection for diffractive-imaging experiments

Delivering sub-micrometer particles to an intense x-ray focus is a crucial aspect of single-particle diffractive-imaging experiments at x-ray free-electron lasers. Enabling direct visualization of sub-micrometer aerosol particle streams without interfering with the operation of the particle injector can greatly improve the overall efficiency of single-particle imaging experiments by reducing the amount of time and sample consumed during measurements. We have developed in-situ non-destructive imaging diagnostics to aid real-time particle injector optimization and x-ray/particle-beam alignment, based on laser illumination schemes and fast imaging detectors. Our diagnostics are constructed to provide a non-invasive rapid feedback on injector performance during measurements, and have been demonstrated during diffraction measurements at the FLASH free-electron laser.Comment: 15 page

Generation of spin currents via Raman scattering

We show theoretically that stimulated spin flip Raman scattering can be used to inject spin currents in doped semiconductors with spin split bands. A pure spin current, where oppositely oriented spins move in opposite directions, can be injected in zincblende crystals and structures. The calculated spin current should be detectable by pump-probe optical spectroscopy and anomalous Hall effect measurement

Iatrogenic pneumatosis intestinalis and pneumatosis hepatis

A term male fetus with meconium-stained liquor was delivered at a peripheral hospital. He developed abdominal distension and bile-stained vomiting shortly after birth. Meconium ingestion was suspected. Gastric lavage was attempted using inappropriately high volumes and concentrations of sodium bicarbonate in this newborn with undiagnosed jejunal atresia. Subsequent abdominal radiographs documented the presence of the jejunal atresia and pneumatosis intestinalis (PI), together with air in both the porta hepatis and liver parenchyma (Figs 1 - 3). The latter features were interpreted as representing necrotising enterocolitis. The child was transferred to Red Cross Children’s Hospital, Cape Town, for corrective surgery

Risk factors affecting software projects in South Africa

This paper reports on an analysis of risk factors relevant to South African software projects. Seven of the most widely cited studies in the research literature regarding software project risk were evaluated along with a detailed examination of the 53 risk factors developed by Schmidt, Lyytinen, Keil & Cule (2001). Forty completed questionnaires, submitted by software project managers, were analysed. The main findings of this research were: • Project managers of varying experience perceived different software risks to be important • Risks relating to quality, cost, time, requirements or methodology were not perceived to be more important than risks relating to people, relationships or change) by project managers The top ten most important risks as perceived by project managers were: • Lack of top management commitment to the project • Unclear/ misunderstood scope/ objectives • Schedule Flaw • Lack of client responsibility, ownership and buy-in of the project and it’s delivered systems • No planning or inadequate planning • Project not based on sound business case • Lack of available skilled personnel • Not managing change properly • Lack of adequate user involvement • Poor risk management From this list it was noted that risks number 5, 6, 7 and 8 were unique to this study and were not found in prior studies in the research literature. It was concluded that the importance of these risks may be unique to South African software projects