The primary headaches: genetics, epigenetics and a behavioural genetic model

The primary headaches, migraine with (MA) and without aura (MO) and cluster headache, all carry a substantial genetic liability. Familial hemiplegic migraine (FHM), an autosomal dominant mendelian disorder classified as a subtype of MA, is due to mutations in genes encoding neural channel subunits. MA/MO are considered multifactorial genetic disorders, and FHM has been proposed as a model for migraine aetiology. However, a review of the genetic studies suggests that the FHM genes are not involved in the typical migraines and that FHM should be considered as a syndromic migraine rather than a subtype of MA. Adopting the concept of syndromic migraine could be useful in understanding migraine pathogenesis. We hypothesise that epigenetic mechanisms play an important role in headache pathogenesis. A behavioural model is proposed, whereby the primary headaches are construed as behaviours, not symptoms, evolutionarily conserved for their adaptive value and engendered out of a genetic repertoire by a network of pattern generators present in the brain and signalling homeostatic imbalance. This behavioural model could be incorporated into migraine genetic research

Il biennio integrato. Esiti del monitoraggio e della valutazione su due anni di attivit\ue0 formative nella provincia di Bologna. Elementi per la riflessione nel sistema integrato. Atti del convegno - Bologna 6 ottobre 2005

Il volume presenta gli Atti del convegno - tenutosi a Bologna il 6 ottobre 2005 - realizzato per presentare gli esiti delle attivit\ue0 di monitoraggio e valutazione dei percorsi integrati tra istruzione e formazione professionale nelle scuole secondarie superiori della provincia di Bologna

Il biennio integrato. Esiti del monitoraggio e della valutazione su due anni di attività formative nella provincia di Bologna. Elementi per la riflessione nel sistema integrato. Atti del convegno - Bologna 6 ottobre 2005

Il volume presenta gli Atti del convegno - tenutosi a Bologna il 6 ottobre 2005 - realizzato per presentare gli esiti delle attivit\ue0 di monitoraggio e valutazione dei percorsi integrati tra istruzione e formazione professionale nelle scuole secondarie superiori della provincia di Bologna

Conceptualising Resourcefulness as a Dispersed Practice

In research on health and wellbeing, resourcefulness is seen as an important skill that can improve quality of life. In design and HCI literature, it has long been acknowledged that resourcefulness is about more than human skills and involves the adaptation, modification and reinvention of technologies in everyday life. In this paper we argue how certain aspects of resourcefulness have so far remained under-theorized, and present a new design perspective on resourcefulness that is grounded in practice theory. In this view, resourcefulness is conceptualised as the dispersed practice of dealing with everyday crises of routine. By elaborating on the complex interplay between means and purpose, we tease out resourcefulness as a practice of reconfiguration. The paper closes by discussing implications of this conceptualisation by zooming in on ways of capturing and designing for resourcefulness. Conceptualising Resourcefulness as a Dispersed Practice (PDF Download Available). Available from: https://www.researchgate.net/publication/317420379_Conceptualising_Resourcefulness_as_a_Dispersed_Practice [accessed Jul 27, 2017]