On the Continuity Mathematics Curriculum Between Primary and Secondary School

AbstractIn this paper we intend to present a review of the National Curriculum continuity in mathematics, in terms of content, from the primary to the secondary. The issues on which we have committed are related to “outputs” learning mathematics fourth class and “inputs” appropriate grade. Because a complete analysis of mathematics curricular content can not be included in an article like this, we summarize only the learning content “fraction”. As far we know, continuity issues relating to both the content of their purchases to specific skills training to students, standards and performance descriptors etc., relative to a subject or a curriculum area, in recent formulation, not be found treated in the literature, even in the didactics of discipline

Hermenéutica del exilio y confluencia de culturas en Ovidio y Vintilă Horia

Exile, whether real or literary, has been a symbol of suffering in any historical period, whose effects cannot be precisely measured nor generalised. While the entire work of Vintilă Horia lies under the sign of expatriation and it certainly belongs to a literature written from and about exile, since the author himself chose Spain as his adopting country, also the narrative architecture of the novel Dieu est né en exil (1960) shapes a peculiar space, under the form of a fictional diary written by the Roman poet Ovid. He was banished by the emperor Augustus to the far eastern borders of the Roman Empire on the coast of the Black Sea, where he spent his last eight years, in desolation and constant hesitation between the two worlds. Paradoxically, in a strange and barbarian place starts Ovid’s initiation experience, overlapped with real and spiritual ways he goes through, towards redemption, on the eve of the Roman spiritual decline and the birth of Christianity. This study aims to analyse the meanings of exile in the novel, inquiring into the metamorphosis of spatial and cultural references, but also into the metaphysical revelation of death

Designers roles in civic pedagogies of co-making: lessons from the Global South and North

This paper investigates how designer-led co-making and civic pedagogy can increase urban learning and resilience through transversal relationalities. We explore two case studies in which designers work with communities to run civic pedagogical projects, using co-making as a tool: Collective Design Practice, in Mumbai, India, co-produced with Muktangan school; and the Eco Nomadic school, situated in Europe. We use theories of agency, correspondence and care to compare the roles of designers and identify the particular moments (or “knots”) where resilience is created. Situated in the Global South and North, respectively, we identify, compare and discuss the research methods and processes used. The research asks how pedagogically supported and designer-led co-making can increase resilience in different parts of the world, particularly when it relates to everyday life. We propose that the civic pedagogy of co-making can be powerful: through it people can have more agency to improve social relations and politics of place; it can make tangible and more understandable political statements and make physically evident the benefits of practice; it can build civic practices of resourcefulness and resilience

Research Regarding the Anticorosiv Protection of Atmospheric and Vacuum Distillation Unit that Process Crude Oil

Due to high boiling temperature, organic acids are present in the warmer areas of metal equipment from atmospheric and vacuum distillation units and determine, increased corrosion processes in furnace tubes, transfer lines, metal equipment within the distillation columns etc. In order to protect the corrosion of metal equipment from atmospheric and vacuum distillation units, against acids, de authors researched solution which integrates corrosion inhibitors and selecting materials for equipment construction. For this purpose, we tested the inhibitor PET 1441, which has dialchilfosfat in his composition and inhibitor based on phosphate ester. In this case, to the metal surface forms a complex phosphorous that forms of high temperature and high fluid speed. In order to form the passive layer and to achieve a 90% protection, we initially insert a shock dose, and in order to ensure further protection there is used a dose of 20 ppm. The check of anticorrosion protection namely the inhibition efficiency is achieved by testing samples made from steel different

Insights into the pathogenesis of nicotine addiction. Could a salivary biosensor be useful in Nicotine Replacement Therapy (NRT)?

Nicotine has gained the attention of the medical community due to its insidious addictive mechanisms which lead to chronic consumption. The multitude of compounds derived from tobacco smoke have local and systemic negative impacts, resulting in a large number of smoking-related pathologies. The present review offers insights into nicotine addiction physiopathology, as well as social and medical implications, with emphasis on its correlation with Advanced Glycation End Products (AGEs). Therapeutic strategies and new approaches to nicotine assessment and cessation treatment are discussed, noting that such strategies could take into account the possibility of slow and gradual nicotine release from a device attached to a prosthetic piece, based on salivary nicotine-concentration feedback. This approach could offer real-time and home-based self-therapy monitoring by the physician and the patient for follow-up and improve long-term cessation treatment success- Graphical abstract

Interface Analysis of the Complex between ERK2 and PTP-SL

The activity of ERK2, an essential component of MAP-kinase pathway, is under the strict control of various effector proteins. Despite numerous efforts, no crystal structure of ERK2 complexed with such partners has been obtained so far. PTP-SL is a major regulator of ERK2 activity. To investigate the ERK2–PTP-SL complex we used a combined method based on cross-linking, MALDI-TOF analysis, isothermal titration calorimetry, molecular modeling and docking. Hence, new insights into the stoichiometry, thermodynamics and interacting regions of the complex are obtained and a structural model of ERK2-PTP-SL complex in a state consistent with PTP-SL phosphatase activity is developed incorporating all the experimental constraints available at hand to date. According to this model, part of the N-terminal region of PTP-SL has propensity for intrinsic disorder and becomes structured within the complex with ERK2. The proposed model accounts for the structural basis of several experimental findings such as the complex-dissociating effect of ATP, or PTP-SL blocking effect on the ERK2 export to the nucleus. A general observation emerging from this model is that regions involved in substrate binding in PTP-SL and ERK2, respectively are interacting within the interface of the complex

Arguments in favour of a postmodern curriculum in initial training of teaching staff

The curriculum for initial teacher education is the component that should be changed in order to update it and to correlate with the other curricula. The reform of the education system should start with teacher training and in the Romanian education system it has always been marginalized. Our proposal is the result of the experience of the authors in the initial and continuous training, supplemented by the needs analysis of the teachers who participated in continuous training programs over time

C-Terminus Glycans with Critical Functional Role in the Maturation of Secretory Glycoproteins

The N-glycans of membrane glycoproteins are mainly exposed to the extracellular space. Human tyrosinase is a transmembrane glycoprotein with six or seven bulky N-glycans exposed towards the lumen of subcellular organelles. The central active site region of human tyrosinase is modeled here within less than 2.5 Å accuracy starting from Streptomyces castaneoglobisporus tyrosinase. The model accounts for the last five C-terminus glycosylation sites of which four are occupied and indicates that these cluster in two pairs - one in close vicinity to the active site and the other on the opposite side. We have analyzed and compared the roles of all tyrosinase N-glycans during tyrosinase processing with a special focus on the proximal to the active site N-glycans, s6:N337 and s7:N371, versus s3:N161 and s4:N230 which decorate the opposite side of the domain. To this end, we have constructed mutants of human tyrosinase in which its seven N-glycosylation sites were deleted. Ablation of the s6:N337 and s7:N371 sites arrests the post-translational productive folding process resulting in terminally misfolded mutants subjected to degradation through the mannosidase driven ERAD pathway. In contrast, single mutants of the other five N-glycans located either opposite to the active site or into the N-terminus Cys1 extension of tyrosinase are temperature-sensitive mutants and recover enzymatic activity at the permissive temperature of 31°C. Sites s3 and s4 display selective calreticulin binding properties. The C-terminus sites s7 and s6 are critical for the endoplasmic reticulum retention and intracellular disposal. Results herein suggest that individual N-glycan location is critical for the stability, regional folding control and secretion of human tyrosinase and explains some tyrosinase gene missense mutations associated with oculocutaneous albinism type I

A Relational Event Approach to Modeling Behavioral Dynamics

This chapter provides an introduction to the analysis of relational event data (i.e., actions, interactions, or other events involving multiple actors that occur over time) within the R/statnet platform. We begin by reviewing the basics of relational event modeling, with an emphasis on models with piecewise constant hazards. We then discuss estimation for dyadic and more general relational event models using the relevent package, with an emphasis on hands-on applications of the methods and interpretation of results. Statnet is a collection of packages for the R statistical computing system that supports the representation, manipulation, visualization, modeling, simulation, and analysis of relational data. Statnet packages are contributed by a team of volunteer developers, and are made freely available under the GNU Public License. These packages are written for the R statistical computing environment, and can be used with any computing platform that supports R (including Windows, Linux, and Mac).