EFFICACY OF SUPPLEMENTATION OF PROBIOTICS ALONG WITH ANTIMICROBIAL AGENTS IN VULVOVAGINAL INFECTIONS IN A TERTIARY CARE HOSPITAL

Objectives: The objectives of the study were to ascertain the efficacy of probiotics along with antimicrobials in the treatment of vulvovaginitis and to evaluate the rate of recurrence. Methods: The study was done on 60 patients who were randomly selected and divided into two groups of 30 each. Prior permission from the Institutional Ethics Committee and higher authorities was obtained before conducting the study. One group received standard treatment including antibacterial, antiviral, and antifungal as per the gynecologist discretion and in other group along with standard treatment, probiotic capsules containing combination of Saccharomyces boulardii, Lactobacillus sporogenes (50 million), Streptococcus faecalis (30 million), Clostridium butyricum (2 million), and Bacillus mesentericus (1 million) given orally twice daily and followed up for a period of 3 months. The drugs were started on the 5th day after menstruation taking starting of the bleeding as day 1. Results: The parameters compared were symptoms and signs (significantly reduced – p-value), clue cells (significantly reduced in number), and recurrence rates (significantly reduced), in 80% of patients smears which were not consistent with BV. Maximum number of patients showed negative KOH mount (71.5%), saline wet mount was negative in 80% of patients in antimicrobial agents + probiotics group. Conclusion: From the present interventional study, probiotics along with antimicrobial agents showed better improvement than antimicrobial agents alone. Hence, supplementation of probiotics along with antimicrobial agents provides better efficacy than antimicrobial agents alone in treating vulvovaginal infections

Relevant Result Generation by Harvesting Web Information

Multimedia question answering approach has been popular to get information online. The answer of the question is provided in the form of the multimedia. Textual answer is not more informative that’s why it will provide the answer in images and video also. Already existing system work only on the narrow domains and it will complex to generalize to handle question. The proposed system does not answer the question directly. It will having the component such as selection of proper pattern of answer, query generation for multimedia search and multimedia data selection and presentation of result. System having the semantic search. Question is ask by the user in the natural language. In question anwer system will check the question by its keywords

Pattern of drug utilization and factors influencing long term blood sugar control among diabetics in a tertiary care hospital- an observational study

Background: To study the Pattern of drug prescribing, utilization, analyse effectives of different therapies and factors influencing medication failure and adherence to treatment among diabetics.Methods: The clinical study was conducted in JJM Medical College and Karuna Trust, Davangere, Karnataka. The patients with diabetes as diagnosed by consultant physician were observed for the pattern of blood glucose control. The fasting blood glucose of the patients were recorded at the end of 1st month, 6th month and 12th month of their treatment period. The study period was from June 2012 till August 2014. The study was conducted after institutional ethical clearance and informed consent was taken from all the patients. The pattern of drugs prescribed for the patients were also analysed. The pattern of control among patients with co morbidities were also analysed using paired sample t test.Results: The results showed that the prescribed drugs were able to control the blood glucose levels of the patients. The percentage of patients with FBS in controlled, mild to moderate control and uncontrolled group were 21%, 33.3% and 45.5% in early treatment period and 36%, 40.9%, and 22.7% after one year treatment period (Significant p value). The pattern of drug utilization showed that the most commonly used drugs were the combination of pioglitazone+glimipride+metformin (19%), combination of glibenclamide+ metformin (18%), only insulin (9%), combination of glimipride+metformin (8%) and combination of gliclazide+metformin (5%).Conclusions: The results show that the intervention by the consultant physician was successful in controlling the blood sugar levels and the reasons for failure of treatment and adherence to treatment were helpful for further treatment of patients. Further such studies in a larger sample will help the consultants in their treatment methods

Intra-conal cavernous haemangioma orbit

Orbital cavernous haemangiomas are most frequent intra-conal, intra-orbital primary tumor in adults. They represent 4% of all orbit tumors and 9-13% of all intracranial cavernous haemangiomas. Forty-two-year-old female came with complaints of protrusion of right eye (RE) since 3 months associated with diminution of vision, headache, and eye ache. Absolute proptometry was 28 mm OD and 20 mm OS. 2 mm of the inferior scleral show was seen in RE. Axial computed tomography (CT) showed unilaterally, moderately enhancing, homogeneous, smooth-contoured mass. The patient underwent right lateral orbitotomy with mass excision under general anesthesia. The histopathological evaluation proved it to be a cavernous haemangioma. We report a case of intra-orbital, intra-conal cavernous hemangioma occurring in a 42-year-old female presenting with proptosis. The tumor was diagnosed on CT and was removed using lateral orbitotomy approach. Patient had significant improvement in symptoms with the mild deterioration of vision