2 research outputs found
Tag-Trigger-Consolidation: A Model of Early and Late Long-Term-Potentiation and Depression
Changes in synaptic efficacies need to be long-lasting in order to serve as a
substrate for memory. Experimentally, synaptic plasticity exhibits phases
covering the induction of long-term potentiation and depression (LTP/LTD) during
the early phase of synaptic plasticity, the setting of synaptic tags, a trigger
process for protein synthesis, and a slow transition leading to synaptic
consolidation during the late phase of synaptic plasticity. We present a
mathematical model that describes these different phases of synaptic plasticity.
The model explains a large body of experimental data on synaptic tagging and
capture, cross-tagging, and the late phases of LTP and LTD. Moreover, the model
accounts for the dependence of LTP and LTD induction on voltage and presynaptic
stimulation frequency. The stabilization of potentiated synapses during the
transition from early to late LTP occurs by protein synthesis dynamics that are
shared by groups of synapses. The functional consequence of this shared process
is that previously stabilized patterns of strong or weak synapses onto the same
postsynaptic neuron are well protected against later changes induced by LTP/LTD
protocols at individual synapses