Insights into neutralization of animal viruses gained from study of influenza virus

It has long been known that the binding of antibodies to viruses can result in a loss of infectivity, or neutralization, but little is understood of the mechanism or mechanisms of this process. This is probably because neutralization is a multifactorial phenomenon depending upon the nature of the virus itself, the particular antigenic site involved, the isotype of immunoglobulin and the ratio of virus to immunoglobulin (see below). Thus not only is it likely that neutralization of one virus will differ from another but that changing the circumstances of neutralization can change the mechanism itself. To give coherence to the topic we are concentrating this review on one virus, influenza type A which is itself well studied and reasonably well understood [1–3]. Reviews of the older literature can be found in references 4 to 7

On Influence of Intensive Stationary Electromagnetic Field on the Behavior of Fermionic Systems

Exact solutions of Schroedinger and Pauli equations for charged particles in an external stationary electromagnetic field of an arbitrary configuration are constructed. Green functions of scalar and spinor particles are calculated in this field. The corresponding equations for complex energy of particles bounded by short range potential are deduced. Boundary condition typical for delta - potential is not used in the treatment. Explicit analytical expressions are given for the shift and width of a quasistationary level for different configurations of the external field. The critical value of electric field in which the idea of quasistationary level becomes meaningless is calculated. It is shown that the common view on the stabilizing role of magnetic field concerns only scalar particles.Comment: 15 pages, no figures, LaTeX2

Gaps, Inexperience, Inconsistencies, and Overlaps: Crisis in the Regulation of Genetically Modified Plants and Animals

The regulation of genetically modified products pursuant to statutes enacted decades prior to the advent of biotechnology has created a regulatory system that is passive rather than proactive about risks, has difficulty adapting to biotechnology advances, and is highly fractured and inefficient-transgenic plants and animals are governed by at least twelve different statutes and five different agencies or services. The deficiencies resulting from this piecemeal approach to regulation unnecessarily expose society and the environment to adverse risks of biotechnology and introduce numerous inefficiencies into the regulatory system. These risks and inefficiencies include gaps in regulation, duplicative and inconsistent regulation, unnecessary regulatory expense, agencies acting outside their areas of expertise, and unnecessary increases in the cost of and delay in the development and commercialization of new biotechnology products. These deficiencies also increase the risk of further unnecessary biotechnology scares, which may cause public overreaction against biotechnology products, preventing the maximization of social welfare. With science and society poised to soar from first-generation biotechnology (focused on crops modified for agricultural benefit), to next-generation developments (including transgenic fish, insects, and livestock, and pharmaceutical-producing and industrial compound-producing plants and animals), it is necessary to establish a comprehensive, efficient, and scientifically rigorous regulatory system. This Article details how to achieve such a result through fixing the deficiencies in, and risks created by, the current regulatory structure. Ignoring many details, the solutions can be summarized in two categories. First, statutory and regulatory gaps that are identified must be closed with new legislation and regulation. Second, regulation of genetically modified products must be shifted from a haphazard model based on statutes not intended to cover biotechnology to a system based upon agency expertise in handling particular types of risks

The Public Perception of Intellectual Property

Though the success of intellectual property law depends upon its ability to affect human perception and behavior, the public psychology of intellectual property has barely been explored. Over 1,700 U.S. adults took part in an experimental study designed to investigate popular conceptions of intellectual property rights. Respondents’ views of what intellectual property rights ought to be differed substantially from what intellectual property law actually provides, and popular conceptions of the basis for intellectual property rights were contrary to commonly accepted bases relied upon in legal and policy decision-making. Linear regression analysis reveals previously unrecognized cultural divides concerning intellectual property law based upon respondents’ income, age, education, political ideology, and gender

Innovation Rewards: Towards Solving the Twin Market Failures of Public Goods

The challenge of achieving socially optimal incentives for innovation in public goods faces twin market failures: a market failure to adequately promote public goods invention and a market failure to implement innovative public goods once developed. Though innovation in private goods sometimes faces the former hurdle, often ameliorated by intellectual property law, the interaction of both market failures for public goods innovation raises unique difficulties. Environmentally beneficial technology presents an illustration of the innovation problem for public goods. Private actors lack sufficient incentives both to engage in environmentally beneficial innovation and to implement such innovation. While traditional intellectual property law and environmental law fail to cure the interaction of these public goods market failures, an innovation rewards system could produce more socially appropriate incentives. Using environmentally beneficial innovation as an example, this Article introduces a new framework for an innovation rewards system for public goods and discusses its implementation and potential advantages

The Public Perception of Intellectual Property

Though the success of intellectual property law depends upon its ability to affect human perception and behavior, the public psychology of intellectual property has barely been explored. Over 1,700 U.S. adults took part in an experimental study designed to investigate popular conceptions of intellectual property rights. Respondents’ views of what intellectual property rights ought to be differed substantially from what intellectual property law actually provides, and popular conceptions of the basis for intellectual property rights were contrary to commonly accepted bases relied upon in legal and policy decision-making. Linear regression analysis reveals previously unrecognized cultural divides concerning intellectual property law based upon respondents’ income, age, education, political ideology, and gender