Studies of the Response of the Prototype CMS Hadron Calorimeter, Including Magnetic Field Effects, to Pion, Electron, and Muon Beams

We report on the response of a prototype CMS hadron calorimeter module to charged particle beams of pions, muons, and electrons with momenta up to 375 GeV/c. The data were taken at the H2 and H4 beamlines at CERN in 1995 and 1996. The prototype sampling calorimeter used copper absorber plates and scintillator tiles with wavelength shifting fibers for readout. The effects of a magnetic field of up to 3 Tesla on the response of the calorimeter to muons, electrons, and pions are presented, and the effects of an upstream lead tungstate crystal electromagnetic calorimeter on the linearity and energy resolution of the combined calorimetric system to hadrons are evaluated. The results are compared with Monte Carlo simulations and are used to optimize the choice of total absorber depth, sampling frequency, and longitudinal readout segmentation.Comment: 89 pages, 41 figures, to be published in NIM, corresponding author: P de Barbaro, [email protected]

Baseline characteristics of patients in the reduction of events with darbepoetin alfa in heart failure trial (RED-HF)

<p>Aims: This report describes the baseline characteristics of patients in the Reduction of Events with Darbepoetin alfa in Heart Failure trial (RED-HF) which is testing the hypothesis that anaemia correction with darbepoetin alfa will reduce the composite endpoint of death from any cause or hospital admission for worsening heart failure, and improve other outcomes.</p> <p>Methods and results: Key demographic, clinical, and laboratory findings, along with baseline treatment, are reported and compared with those of patients in other recent clinical trials in heart failure. Compared with other recent trials, RED-HF enrolled more elderly [mean age 70 (SD 11.4) years], female (41%), and black (9%) patients. RED-HF patients more often had diabetes (46%) and renal impairment (72% had an estimated glomerular filtration rate <60 mL/min/1.73 m2). Patients in RED-HF had heart failure of longer duration [5.3 (5.4) years], worse NYHA class (35% II, 63% III, and 2% IV), and more signs of congestion. Mean EF was 30% (6.8%). RED-HF patients were well treated at randomization, and pharmacological therapy at baseline was broadly similar to that of other recent trials, taking account of study-specific inclusion/exclusion criteria. Median (interquartile range) haemoglobin at baseline was 112 (106–117) g/L.</p> <p>Conclusion: The anaemic patients enrolled in RED-HF were older, moderately to markedly symptomatic, and had extensive co-morbidity.</p&gt

Clinical efficacy of native drug Adgelon in knee osteoarthritis

Results of treatment of 76 pts with knee osteoarthritis with native drug Adgelon (glycoprotein possessing biological activity at super low doses) are presented. WOMAC index, Lequesne functional index and SF-36 questionnaire show analgesic effect and quality of life improvement after 6 intra-articular adgelon injections during 3 weeks. Subsequent follow up for 2 months revealed aftereffect of the drug

Mass-spectrometric study on

The present study continues the 2015–2016 research project on biological characteristics of stable isotopes fractionation in grapes taking into account the agro-climatic growth conditions of this representative of the C3-pathway of photosynthesis group of plants in different geographical Black Sea regions. The first parts of the project were presented at the 39th and 40th Congresses of OIV in Bento Gonçalves (Brazil) and Sofia (Bulgaria). The scientific data on compositions of 13C/12C carbon and 18O/16O oxygen stable isotopes in carbohydrates, organic acids, and intracellular water were obtained for grapes of 2015–2016 growing seasons in the four areas of the Crimean peninsula as well as in several areas of the Don Basin and the Western Caspian region. This report presents the results of the 2017 season study of 13C/12C carbon and 18O/16O oxygen stable isotopes in carbohydrates and intracellular water of 12 red and white grape varieties (Aligote, Rkatsiteli, Sauvignon Zeleny, Chardonnay, Cabernet Sauvignon, Sauvignon Blanc, Merlot, Risling, Pinot Noir, Cabernet Franc, Sira, Krasnostop) as well as in ethanol of wines made from corresponding grapes from the Crimean Peninsula and South-West Coast of the Greater Caucasus. To measure the ratio of carbon isotopes 13C/12C in grape (must) carbohydrates and wine ethanol the Flash-Combustion technique (FC-IRMS/SIRA) has been used, while the method of isotopic equilibration (EQ-IRMS/SIRA) has been used for the measurement of 18O/16O oxygen isotopes ratio in the intracellular water of grapes (must) and in the water fraction of wine. The GC-Combustion technique (GC-IRMS/SIRA) has been used for the first time to measure the carbon isotopes 13C/12C distribution in ethanol of studied wines. It has been found that the δ13CVPDB values for carbohydrates of red and white grape varieties as a result of biological fractionation of carbon isotopes in the agro-climatic conditions of plant growth (2017 season) for the studied geographical areas formed the following quantitative ranges: from − 26.72 to − 23.35‰ (the Crimean Peninsula) and from − 25.92 to − 23.87‰ (South-West Coast of the Greater Caucasus). The δ13CVPDB values for wine ethanol are in the following ranges: from − 28.15 to − 24.47‰ (the Crimean Peninsula) and from − 27.29 to − 25.78‰ (South-West Coast of the Greater Caucasus). The δ18OVSMOW values in intracellular water of grapes of the 2017 season range from − 1.24 to 2.17‰ (the Crimean Peninsula) and from 1.08 to 4.09‰ (South-West Coast of the Greater Caucasus). The results of this study show, in comparison with the results of studies of the 2015 and 2016 seasons, a decrease in the δ13CVPDB values for carbohydrates of grapes and ethanol of wine, which is explained by the changed climatic conditions of grapes growing in the vegetation period of 2017

CORRECTION DYSBACTERIOSIS IN REHABILITATION PROGRAMS FOR CHILDREN UNDERGOING SURGERY ON THE COLON AND ANORECTAL ZONE

Rehabilitation of children undergoing surgery for colon and rectum is an important issue of pediatric surgery. Its relevance is due to the widespread development of these anomalies requiring surgical correction –  1:4000–5000 newborns. In all patients with this disease is marked by inflammatory changes in the intestinal mucosa. Use of      73  antibacterial drugs in the pre-and postoperative periods in 100% of cases, causes the development of  intestinal dysbiosis.Dysbiosis uniqueness is manifested in the fact that this disease is in the interests of doctors of different specialties. Traditional methods for correcting violations mikrobiotsinoz gut is not always sufficiently effective in surgical patients. The purpose of this study to optimize the treatment and prevention circuit dysbacteriosis in surgical patients

Mass-spectrometric study on13C/12C carbon and18O/16O oxygenstable isotopes distributions in grapes and wines from the BlackSea regions

The present study continues the 2015–2016 research project on biological characteristics of stableisotopes fractionation in grapes taking into account the agro-climatic growth conditions of this representativeof the C3-pathway of photosynthesis group of plants in different geographical Black Sea regions. The firstparts of the project were presented at the 39th and 40th Congresses of OIV in Bento Gonc ̧alves (Brazil) andSofia (Bulgaria). The scientific data on compositions of13C/12C carbon and18O/16O oxygen stable isotopes incarbohydrates, organic acids, and intracellular water were obtained for grapes of 2015–2016 growing seasonsin the four areas of the Crimean peninsula as well as in several areas of the Don Basin and the Western Caspianregion. This report presents the results of the 2017 season study of13C/12C carbon and18O/16O oxygen stableisotopes in carbohydrates and intracellular water of 12 red and white grape varieties (Aligote, Rkatsiteli,Sauvignon Zeleny, Chardonnay, Cabernet Sauvignon, Sauvignon Blanc, Merlot, Risling, Pinot Noir, CabernetFranc, Sira, Krasnostop) as well as in ethanol of wines made from corresponding grapes from the CrimeanPeninsula and South-West Coast of the Greater Caucasus. To measure the ratio of carbon isotopes13C/12Cin grape (must) carbohydrates and wine ethanol the Flash-Combustion technique (FC-IRMS/SIRA) has beenused, while the method of isotopic equilibration (EQ-IRMS/SIRA) has been used for the measurement of18O/16O oxygen isotopes ratio in the intracellular water of grapes (must) and in the water fraction of wine. TheGC-Combustion technique (GC-IRMS/SIRA) has been used for the first time to measure the carbon isotopes13C/12C distribution in ethanol of studied wines. It has been found that theδ13CVPDBvalues for carbohydratesof red and white grape varieties as a result of biological fractionation of carbon isotopes in the agro-climaticconditions of plant growth (2017 season) for the studied geographical areas formed the following quantitativeranges: from−26.72 to−23.35‰ (the Crimean Peninsula) and from−25.92 to−23.87‰ (South-West Coastof the Greater Caucasus). Theδ13CVPDBvalues for wine ethanol are in the following ranges: from−28.15to−24.47‰ (the Crimean Peninsula) and from−27.29 to−25.78‰ (South-West Coast of the GreaterCaucasus). Theδ18OVSMOWvalues in intracellular water of grapes of the 2017 season range from−1.24to 2.17‰ (the Crimean Peninsula) and from 1.08 to 4.09‰ (South-West Coast of the Greater Caucasus). Theresults of this study show, in comparison with the results of studies of the 2015 and 2016 seasons, a decreasein theδ13CVPDBvalues for carbohydrates of grapes and ethanol of wine, which is explained by the changedclimatic conditions of grapes growing in the vegetation period of 201

Peculiarities of hemodynamic status of healthy newborns in early neonatal period

The study is devoted to the assessment of hemodynamic parameters in healthy newborns in the early neonatal period. The authors examined 76 healthy newborns aged up to 7 days. 12 (15.7%) of 76 children were diagnosed with intrauterine growth retardation of hypotrophic type and 14 children (18.49%) were premature. The authors evaluated the diameter of the outgoing tract of the left ventricle, pulmonary artery trunk, mitral and tricuspid valve rings. The disc method was used to determine the final diastolic volume of the left ventricle. The pulse Doppler was used to determine the integrated flow rate in the outflow tract of the left ventricle, the pulmonary artery trunk, on the mitral and tricuspid valves. After US there were calculated the stroke volume index, cardiac index, total peripheral vascular resistance and oxygen delivery index.The results. It integral flow rate was found to be a key indicator of central hemodynamics, which determines the magnitude of the stroke volume. Body weight and the presence of functioning fetal communications do not have a significant impact on the indexed systemic blood flow in healthy newborns. There is a direct correlation between the integral blood flow velocity and the stroke volume index, which is characteristic of all intracardiac anatomical structures