The possible site of trauma in leucodermic/vitiligenous skin

The histological, histochemical and ultrastructural changes in leucodermic skins are compared with those of normal human skins in order to find out if the former represents a traumatized skin. There were no significant differences in the histochemical features between the normal and leucodermic human skins, Ultrastructural studies however revealed that the melanocytes in the affected areas were undergoing degenerative changes such as loss of melanosomes, structural alterations in melanosomes and the presence of wide intracellular spaces. It is, therefore, suggested that in leucoderma, there occurs cellular traumatization rather than traumatisation at the organ level

Optimised Realistic Test Input Generation Using Web Services

Abstract. We introduce a multi-objective formulation of service-oriented testing, focusing on the balance between service price and reliability. We experimented with NSGA2 for this problem, investigating the effect on performance and quality of composition size, topology and the number of services discovered. For topologies small enough for exhaustive search we found that NSGA2 finds a pareto front very near (the fronts are a Euclidean distance of ∼ 0.00024 price-reliability points apart) the true pareto front. Regarding performance, we find that composition size has the strongest effect, with smaller topologies consuming more machine time; a curious effect we believe is due to the influence of crowding dis-tance. Regarding result quality, our results reveal that size and topology have more effect on the front found than the number of service choices discovered. As expected the cost-reliability relationship (logarithmic, lin-ear, exponential) is replicated in the front discovered when correlation is high, but as the price-reliability correlation decreases, we find fewer solutions on the front and the front becomes less smooth.

Adaptive Evolution of a Stress Response Protein

Some cancers are mediated by an interplay between tissue damage, pathogens and localised innate immune responses, but the mechanisms that underlie these linkages are only beginning to be unravelled.Here we identify a strong signature of adaptive evolution on the DNA sequence of the mammalian stress response gene SEP53, a member of the epidermal differentiation complex fused-gene family known for its role in suppressing cancers. The SEP53 gene appears to have been subject to adaptive evolution of a type that is commonly (though not exclusively) associated with coevolutionary arms races. A similar pattern of molecular evolution was not evident in the p53 cancer-suppressing gene.Our data thus raises the possibility that SEP53 is a component of the mucosal/epithelial innate immune response engaged in an ongoing interaction with a pathogen. Although the pathogenic stress mediating adaptive evolution of SEP53 is not known, there are a number of well-known candidates, in particular viruses with established links to carcinoma

Functional Conservation of Cis-Regulatory Elements of Heat-Shock Genes over Long Evolutionary Distances

Transcriptional control of gene regulation is an intricate process that requires precise orchestration of a number of molecular components. Studying its evolution can serve as a useful model for understanding how complex molecular machines evolve. One way to investigate evolution of transcriptional regulation is to test the functions of cis-elements from one species in a distant relative. Previous results suggested that few, if any, tissue-specific promoters from Drosophila are faithfully expressed in C. elegans. Here we show that, in contrast, promoters of fly and human heat-shock genes are upregulated in C. elegans upon exposure to heat. Inducibility under conditions of heat shock may represent a relatively simple “on-off” response, whereas complex expression patterns require integration of multiple signals. Our results suggest that simpler aspects of regulatory logic may be retained over longer periods of evolutionary time, while more complex ones may be diverging more rapidly

Deploying Search Based Software Engineering with Sapienz at Facebook

We describe the deployment of the Sapienz Search Based Software Engineering (SBSE) testing system. Sapienz has been deployed in production at Facebook since September 2017 to design test cases, localise and triage crashes to developers and to monitor their fixes. Since then, running in fully continuous integration within Facebook’s production development process, Sapienz has been testing Facebook’s Android app, which consists of millions of lines of code and is used daily by hundreds of millions of people around the globe. We continue to build on the Sapienz infrastructure, extending it to provide other software engineering services, applying it to other apps and platforms, and hope this will yield further industrial interest in and uptake of SBSE (and hybridisations of SBSE) as a result