Validity of quasi-degenerate neutrino mass models and their predictions on baryogenesis

Quasi-degenerate neutrino mass models (QDN) which can explain the current data on neutrino masses and mixings,are studied. In the first part, we study the effect of CP-phases on QDN mass matrix obeying $\mu-\tau$ symmetry in normal hierarchical (QD-NH) and inverted hierarchical (QD-IH) patterns.The numerical predictions are consistent with observed data on solar mixing angle, absolute neutrino mass parameter consistent with neutrinoless double beta decay mass parameter and sum of three absolute neutrino masses from cosmological bound.The neutrino mass matrix is parameterized using only two unknown parameters. The second part deals with the estimation of observed baryon asymmetry of the universe. The prediction is nearly consistent with observation with flavoured thermal leptogenesis scenario. QD-NH model appears to be more favourable than those of QD-IH models.The present analysis shows that the three absolute neutrino masses may exhibit quasi-degenerate pattern in nature. They are far from discrimination at the moment.Comment: 17 pages, no figure, poster presentation in the 25th International Conference on neutrino physics and Astrophysics, Kyoto, Japan, July,201

Leptogenesis in Inflationary Universe

We investigate the leptogenesis via decays of heavy Majorana neutrinos which are produced non-thermally in inflaton decays. We make a comprehensive study on the leptogenesis assuming various supersymmetric (SUSY) models for hybrid, new and topological inflations. For an estimation of the lepton asymmetry we adopt the Froggatt-Nielsen mechanism for mass matrices of quarks and leptons. We find that all of these models are successful to produce the lepton asymmetry enough to explain the baryon number in the present universe. Here we impose low reheating temperatures such as $T_R \lesssim 10^8$ GeV in order to suppress the abundance of gravitinos not to conflict with the big-bang nucleosynthesis. Furthermore, we find that the leptogenesis works very well even with $T_R \simeq 10^{6}$ GeV in the SUSY hybrid or new inflation model. It is known that such a reheating temperature is low enough to suppress the abundance of gravitinos of mass $m_{3/2} \simeq 100$ GeV--1 TeV. Thus, the leptogenesis is fully consistent with the big-bang nucleosynthesis in a wide region of the gravitino mass.Comment: 42 pages, 17 figure

Natural Chaotic Inflation in Supergravity and Leptogenesis

We comprehensively investigate a chaotic inflation model proposed recently in the framework of supergravity. In this model, the form of K\"ahler potential is determined by a symmetry, that is, the Nambu-Goldstone-like shift symmetry, which guarantees the absence of the exponential factor in the potential for the inflaton field. Though we need the introduction of small parameters, the smallness of the parameters is justified also by symmetries. That is, the zero limit of the small parameters recovers symmetries, which is natural in the 't Hooft's sense. The leptogenesis scenario via the inflaton decay in this chaotic inflation model is also discussed. We find that the lepton asymmetry enough to explain the present baryon number density is produced for low reheating temperatures avoiding the overproduction of gravitinos.Comment: 16 pages. To appear in Phys. Rev.

Neutralino versus axion/axino cold dark matter in the 19 parameter SUGRA model

We calculate the relic abundance of thermally produced neutralino cold dark matter in the general 19 parameter supergravity (SUGRA-19) model. A scan over GUT scale parameters reveals that models with a bino-like neutralino typically give rise to a dark matter density \Omega_{\tz_1}h^2\sim 1-1000, i.e. between 1 and 4 orders of magnitude higher than the measured value. Models with higgsino or wino cold dark matter can yield the correct relic density, but mainly for neutralino masses around 700-1300 GeV. Models with mixed bino-wino or bino-higgsino CDM, or models with dominant co-annihilation or A-resonance annihilation can yield the correct abundance, but such cases are extremely hard to generate using a general scan over GUT scale parameters; this is indicative of high fine-tuning of the relic abundance in these cases. Requiring that m_{\tz_1}\alt 500 GeV (as a rough naturalness requirement) gives rise to a minimal probably dip in parameter space at the measured CDM abundance. For comparison, we also scan over mSUGRA space with four free parameters. Finally, we investigate the Peccei-Quinn augmented MSSM with mixed axion/axino cold dark matter. In this case, the relic abundance agrees more naturally with the measured value. In light of our cumulative results, we conclude that future axion searches should probe much more broadly in axion mass, and deeper into the axion coupling.Comment: 23 pages including 17 .eps figure

Neutralino Dark Matter from MSSM Flat Directions in light of WMAP Result

The minimal supersymmetric standard model (MSSM) has a truly supersymmetric way to explain both the baryon asymmetry and cold dark matter in the present Universe, that is, ``Affleck-Dine baryo/DM-genesis.'' The associated late-time decay of Q-balls directly connects the origins of the baryon asymmetry and dark matter, and also predicts a specific nature of the LSP. In this paper, we investigate the prospects for indirect detection of these dark matter candidates observing high energy neutrino flux from the Sun, and hard positron flux from the halo. We also update the previous analysis of the direct detection in hep-ph/0205044 by implementing the recent result from WMAP satellite.Comment: 32 pages, including 40 figure

Hidden SUSY at the LHC: the light higgsino-world scenario and the role of a lepton collider

While the SUSY flavor, CP and gravitino problems seem to favor a very heavy spectrum of matter scalars, fine-tuning in the electroweak sector prefers low values of superpotential mass \mu. In the limit of low \mu, the two lightest neutralinos and light chargino are higgsino-like. The light charginos and neutralinos may have large production cross sections at LHC, but since they are nearly mass degenerate, there is only small energy release in three-body sparticle decays. Possible dilepton and trilepton signatures are difficult to observe after mild cuts due to the very soft p_T spectrum of the final state isolated leptons. Thus, the higgsino-world scenario can easily elude standard SUSY searches at the LHC. It should motivate experimental searches to focus on dimuon and trimuon production at the very lowest p_T(\mu) values possible. If the neutralino relic abundance is enhanced via non-standard cosmological dark matter production, then there exist excellent prospects for direct or indirect detection of higgsino-like WIMPs. While the higgsino-world scenario may easily hide from LHC SUSY searches, a linear e^+e^- collider or a muon collider operating in the \sqrt{s}\sim 0.5-1 TeV range would be able to easily access the chargino and neutralino pair production reactions.Comment: 20 pages including 12 .eps figure

Prospective study of daily low-dose nedaplatin and continuous 5-fluorouracil infusion combined with radiation for the treatment of esophageal squamous cell carcinoma

<p>Abstract</p> <p>Background</p> <p>Protracted low-dose concurrent chemotherapy combined with radiation has been proposed for enhanced treatment results for esophageal cancer. We evaluated the efficacy and the toxicity of a novel regimen of daily low-dose nedaplatin (cis-diammine-glycolatoplatinum) and continuous infusion of 5-fluorouracil (5-FU) with radiation in patients with esophageal squamous cell carcinoma.</p> <p>Methods</p> <p>Between January 2003 and June 2008, 33 patients with clinical stage I to IVB esophageal squamous cell carcinoma were enrolled. Nedaplatin (10 mg/body/day) was administered daily and 5-FU (500 mg/body/day) was administered continuously for 20 days. Fractionated radiotherapy for a total dose of 50.4-66 Gy was administered together with chemotherapy. Additional chemotherapy with nedaplatin and 5-FU was optionally performed for a maximum of 5 courses after chemoradiotherapy. The primary end-point of this study was to evaluate the tumor response, and the secondary end-points were to evaluate the toxicity and the overall survival.</p> <p>Results</p> <p>Twenty-two patients (72.7%) completed the regimen of chemoradiotherapy. Twenty patients (60.6%) achieved a complete response, 10 patients (30.3%) a partial response. One patient (3.0%) had a stable disease, and 2 (6.1%) a progressive disease. The overall response rate was 90.9% (95% confidence interval: 75.7%-98.1%). For grade 3-4 toxicity, leukopenia was observed in 75.8% of the cases, thrombocytopenia in 24.2%, anemia in 9.1%, and esophagitis in 36.4%, while late grade 3-4 cardiac toxicity occurred in 6.1%. Additional chemotherapy was performed for 26 patients (78.8%) and the median number of courses was 3 (range, 1-5). The 1-, 2- and 3-year survival rates were 83.9%, 76.0% and 58.8%, respectively. The 1- and 2-year survival rates were 94.7% and 88.4% in patients with T1-3 M0 disease, and 66.2% and 55.2% in patients with T4/M1 disease.</p> <p>Conclusion</p> <p>The treatment used in our study may yield a high complete response rate and better survival for each stage of esophageal squamous cell carcinoma.</p> <p>Trial registration</p> <p>ClinicalTrials.gov Identifier: NCT00197444</p

Evolution of Genome Size and Complexity in Pinus

BACKGROUND: Genome evolution in the gymnosperm lineage of seed plants has given rise to many of the most complex and largest plant genomes, however the elements involved are poorly understood. METHODOLOGY/PRINCIPAL FINDINGS: Gymny is a previously undescribed retrotransposon family in Pinus that is related to Athila elements in Arabidopsis. Gymny elements are dispersed throughout the modern Pinus genome and occupy a physical space at least the size of the Arabidopsis thaliana genome. In contrast to previously described retroelements in Pinus, the Gymny family was amplified or introduced after the divergence of pine and spruce (Picea). If retrotransposon expansions are responsible for genome size differences within the Pinaceae, as they are in angiosperms, then they have yet to be identified. In contrast, molecular divergence of Gymny retrotransposons together with other families of retrotransposons can account for the large genome complexity of pines along with protein-coding genic DNA, as revealed by massively parallel DNA sequence analysis of Cot fractionated genomic DNA. CONCLUSIONS/SIGNIFICANCE: Most of the enormous genome complexity of pines can be explained by divergence of retrotransposons, however the elements responsible for genome size variation are yet to be identified. Genomic resources for Pinus including those reported here should assist in further defining whether and how the roles of retrotransposons differ in the evolution of angiosperm and gymnosperm genomes

BRAF mutations and phosphorylation status of mitogen-activated protein kinases in the development of flat and depressed-type colorectal neoplasias

Although some molecular differences between flat-depressed neoplasias (FDNs) and protruding neoplasias (PNs) have been reported, it is uncertain if the BRAF mutations or the status of phosphorylated mitogen-activated protein kinase (p-MAPK) are different between theses two groups. We evaluated the incidence of BRAF and KRAS mutations, high-frequency microsatellite instability (MSI-H), and the immunohistochemical status of p-MAPK in the nonserrated neoplasias (46 FDNs and 57 PNs). BRAF mutations were detected in four FDNs (9%) and none of PNs (P=0.0369 by Fisher's exact test). KRAS mutations were observed in none of FDNs and in 14 PNs (25%; P=0.0002 by Fisher's exact test). MSI-H was detected in seven out of 44 FDNs (16%) and in one out of 52 of PNs (2%) (P=0.022 by Fisher's exact test). Type B and C immunostaining for p-MAPK was observed in 34 out of 46 FDNs (72%), compared with 24 out of 55 PNs (44%; P=0.0022 by χ2 test). There was no significant difference in the type B and C immunostaining of p-MAPK between FDNs with and without BRAF mutations. BRAF and KRAS mutations are mutually exclusive in the morphological characteristics of colorectal nonserrated neoplasia. Abnormal accumulation of p-MAPK protein is more likely to be implicated in the tumorigenesis of FDNs than of PNs. However, this abnormality in FDNs might occur via the genetic alteration other than BRAF or KRAS mutation