Goertler instability on an airfoil

An effective computational scheme was developed to study the growth/damping of Goertler vortices along walls of variable curvature. Computational experiments indicate that when the amplification rates for the u-, v-, and w-perturbations are the same, the finite difference approach to solve the initial value problem and the normal mode approach give identical results for the Blasius boundary layer on constant curvature concave walls. The growth of Goertler vortices was rapid in the concave regions and was followed by sharp damping in the convex region. However, multiple sets of counter-rotating vortices were formed and remained far downstream in the convex region. The current computational scheme can be easily extended to more realistic problems including variable pressure gradients and suction effects

Recent Gene Therapy Advancements for Neurological Diseases

The past few years have seen rapid advancements in vector-mediated gene transfer to the nervous system and modest successes in human gene therapy trials. The purpose of this review is to describe commonly-used viral gene transfer vectors and recent advancements towards producing meaningful gene-based treatments for central nervous system (CNS) disorders. Gene therapy trials for Canavan disease, Batten disease, adrenoleukodystrophy, and Parkinson’s disease are discussed to illustrate the current state of clinical gene transfer to the CNS. Preclinical studies are under way for a number of diseases, primarily lysosomal storage disorders, using a newer generation of vectors and delivery strategies. Relevant studies in animal models are highlighted for Mucopolysaccharidosis IIB and Krabbe disease to provide a prelude for what can be expected in the coming years for human gene transfer trials, using recent advancements in gene transfer technology. In conclusion, recent improvements in CNS gene transfer technology are expected to significantly increase the degree of disease rescue in future CNS-directed clinical trials, exceeding the modest clinical successes that have been observed so far

Association between COX-2 rs 6681231 Genotype and Interleukin-6 in Periodontal Connective Tissue. A Pilot Study

This study was partially undertaken at the UCL Eastman Dental Institute, which received a proportion of funding from the Department of Health’s National Institute of Health Research (NIHR) Biomedical Research Centres funding scheme

Ayurveda management of vatahata vartma - A case report

Lagophthalmos is a condition characterized by incomplete or abnormal closure of eyelids along with the evaporation of tear film. If left untreated, it progresses to corneal ulceration, perforation, and visual loss. Conservative nonsurgical treatment includes the use of artificial tears, ointments, and therapeutic contact lenses. However, if nonsurgical approaches are not effective, surgical procedures such as tarsorrhaphy and gold/platinum implantation are used which are expensive with risks of poor cosmetic appearance. The current case was diagnosed as lagophthalmos which can be clinically correlated to Vatahata vartma described in Ayurveda. Amapachana followed by Panchakarma and Kriyakarmas along with Vata shamana chikitsa were adopted which are cost-effective, less invasive, and cosmetic friendly when compared with conventional science. This article highlights the successful reduction in core symptoms of lagophthalmos with the Ayurveda line of treatment

"Comparative Estimation Of Salivary Aspartate Aminotransferase Levels In Patients With Varying Periodontal Conditions -A Clinico -Chemical Study"

and there were statistically significant differences (p< 0.05) between levels from group C0 to C1, C3 and C4. Higher salivary aspartate aminotransferase levels seem to be related to periodontal destruction that includes periodontal pockets and gingival bleeding