6,086 research outputs found
Structured Bayesian Compression for Deep Neural Networks Based on The Turbo-VBI Approach
With the growth of neural network size, model compression has attracted
increasing interest in recent research. As one of the most common techniques,
pruning has been studied for a long time. By exploiting the structured sparsity
of the neural network, existing methods can prune neurons instead of individual
weights. However, in most existing pruning methods, surviving neurons are
randomly connected in the neural network without any structure, and the
non-zero weights within each neuron are also randomly distributed. Such
irregular sparse structure can cause very high control overhead and irregular
memory access for the hardware and even increase the neural network
computational complexity. In this paper, we propose a three-layer hierarchical
prior to promote a more regular sparse structure during pruning. The proposed
three-layer hierarchical prior can achieve per-neuron weight-level structured
sparsity and neuron-level structured sparsity. We derive an efficient
Turbo-variational Bayesian inferencing (Turbo-VBI) algorithm to solve the
resulting model compression problem with the proposed prior. The proposed
Turbo-VBI algorithm has low complexity and can support more general priors than
existing model compression algorithms. Simulation results show that our
proposed algorithm can promote a more regular structure in the pruned neural
networks while achieving even better performance in terms of compression rate
and inferencing accuracy compared with the baselines
Effect of isospin dependent cross-section on fragment production in the collision of charge asymmetric nuclei
To understand the role of isospin effects on fragmentation due to the
collisions of charge asymmetric nuclei, we have performed a complete
systematical study using isospin dependent quantum molecular dynamics model.
Here simulations have been carried out for , where n
varies from 47 to 59 and for , where m varies from 14
to 23. Our study shows that isospin dependent cross-section shows its influence
on fragmentation in the collision of neutron rich nuclei
Discrimination between two mechanisms of surface-scattering in a single-mode waveguide
Transport properties of a single-mode waveguide with rough boundary are
studied by discrimination between two mechanisms of surface scattering, the
amplitude and square-gradient ones. Although these mechanisms are generically
mixed, we show that for some profiles they can separately operate within
non-overlapping intervals of wave numbers of scattering waves. This effect may
be important in realistic situations due to inevitable long-range correlations
in scattering profiles.Comment: 5 pages, 3 figure
Investment Opportunities Forecasting: Extending the Grammar of a GP-based Tool
In this paper we present a new version of a GP financial forecasting tool, called EDDIE 8. The novelty of this version is that it allows the GP to search in the space of indicators, instead of using pre-specified ones. We compare EDDIE 8 with its predecessor, EDDIE 7, and find that new and improved solutions can be found. Analysis also shows that, on average, EDDIE 8's best tree performs better than the one of EDDIE 7. The above allows us to characterize EDDIE 8 as a valuable forecasting tool
CD4+ T-cell responses to Epstein-Barr virus nuclear antigen EBNA1 in Chinese populations are highly focused on novel C-terminal domain-derived epitopes
Epstein-Barr virus nuclear antigen EBNA1, the one viral protein uniformly expressed in nasopharyngeal carcinoma (NPC), represents a prime target for T-cell-based immunotherapy. However, little is known about the EBNA1 epitopes, particularly CD4 epitopes, presented by HLA alleles in Chinese people, the group at highest risk for NPC. We analyzed the CD4 T-cell responses to EBNA1 in 78 healthy Chinese donors and found marked focusing on a small number of epitopes in the EBNA1 C-terminal region, including a DP5- restricted epitope that was recognized by almost half of the donors tested and elicited responses able to recognize EBNA1-expressing, DP5-positive target cells
Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: The cellular mechanism
Extensive studies have revealed that berberine, a small molecule derived from Coptidis rhizoma (Huanglian in Chinese) and many other plants, has strong anti-tumor properties. To better understand berberine-induced cell death and its underlying mechanisms in cancer, we examined autophagy and apoptosis in the human hepatic carcinoma cell lines HepG2 and MHCC97-L. The results of this study indicate that berberine can induce both autophagy and apoptosis in hepatocellular carcinoma cells. Berberine-induced cell death in human hepatic carcinoma cells was diminished in the presence of the cell death inhibitor 3-methyladenine, or following interference with the essential autophagy gene Atg5. Mechanistic studies showed that berberine may activate mitochondrial apoptosis in HepG2 and MHCC97-L cells by increasing Bax expression, the formation of permeable transition pores, cytochrome C release to cytosol, and subsequent activation of the caspases 3 and 9 execution pathway. Berberine may also induce autophagic cell death in HepG2 and MHCC97-L cells through activation of Beclin-1 and inhibition of the mTOR-signaling pathway by suppressing the activity of Akt and up-regulating P38 MAPK signaling. This is the first study to describe the role of Beclin-1 activation and mTOR inhibition in berberine-induced autophagic cell death. These results further demonstrate the potential of berberine as a therapeutic agent in the emerging list of cancer therapies with novel mechanisms. © 2010 Wiley-Liss, Inc.postprin
The Microscopic Approach to Nuclear Matter and Neutron Star Matter
We review a variety of theoretical and experimental investigations aimed at
improving our knowledge of the nuclear matter equation of state. Of particular
interest are nuclear matter extreme states in terms of density and/or isospin
asymmetry. The equation of state of matter with unequal concentrations of
protons and neutrons has numerous applications. These include heavy-ion
collisions, the physics of rare, short-lived nuclei and, on a dramatically
different scale, the physics of neutron stars. The "common denominator" among
these (seemingly) very different systems is the symmetry energy, which plays a
crucial role in both the formation of the neutron skin in neutron-rich nuclei
and the radius of a neutron star (a system 18 orders of magnitude larger and 55
orders of magnitude heavier). The details of the density dependence of the
symmetry energy are not yet sufficiently constrained. Throughout this article,
our emphasis will be on the importance of adopting a microscopic approach to
the many-body problem, which we believe to be the one with true predictive
power.Comment: 56 pages, review article to appear in the International Journal of
Modern Physics
Generalization and induction: Misconceptions, clarifications and a classification of induction
In “Generalizing Generalizability in Information Systems Research,” Lee and Baskerville (2003) try to clarify generalization and classify it into four types. Unfortunately, their account is problematic. We propose repairs. Central among these is our balance-of-evidence argument that we should adopt the view that Hume’s problem of induction has a solution, even if we do not know what it is. We build upon this by proposing an alternative classification of induction. There are five types of generalization: (1) theoretical, (2) within-population, (3) cross-population, (4) contextual, and (5) temporal, with theoretical generalization being across the empirical and theoretical levels and the rest within the empirical level. Our classification also includes two kinds of inductive reasoning that do not belong to the domain of generalization. We then discuss the implications of our classification for information systems research
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