98 research outputs found
Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis
While the human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATL), to date, its close relative HTLV-2 is not associated with ATL or other types of malignancies. Accumulating evidence shows that HTLV-1 Tax1 and HTLV-2 Tax2 have many shared activities, but the two proteins have a limited number of significantly distinct activities, and these distinctions appear to play key roles in HTLV-1 specific pathogenesis. In this review, we summarize the functions of Tax1 associated with cell survival, cell proliferation, persistent infection as well as pathogenesis. We emphasize special attention to distinctions between Tax1 and Tax2
Increased expression of OX40 is associated with progressive disease in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis
External standard method for the determination of the efficiency in liquid scintillation counting
Cobalt Phenanthroline-Indole Macrocycles as Highly Active Electrocatalysts for Oxygen Reduction
Copper-Catalyzed Regio-Controlled Oxidative Coupling Polymerization of 2,5-Dimethylphenol
Triangular Trinuclear Metal-N(4) Complexes with High Electrocatalytic Activity for Oxygen Reduction
The Effect of Electrical Stimulation of the Hypothalamus and Other Brain Areas on Urea Cycle Enzymatic Activities in the Liver in Rabbits: Experimental Studies on Brain and Liver Interrelationship
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