3,238 research outputs found
A Dynamical Model of the Inner Galaxy
An extension of Schwarzschild's galaxy-building technique is presented that,
for the first time, enables one to build Schwarzschild models with known
distribution functions (DFs). The new extension makes it possible to combine a
DF that depends only on classical integrals with orbits that respect
non-classical integrals. With such a combination, Schwarzschild's orbits are
used only to represent the difference between the true galaxy DF and an
approximating classical DF. The new method is used to construct a dynamical
model of the inner Galaxy. The model is based on an orbit library that contains
22168 regular orbits. The model aims to reproduce the three-dimensional mass
density of Binney, Gerhard & Spergel (1997), which was obtained through
deprojection of the COBE surface photometry, and to reproduce the observed
kinematics in three windows - namely Baade's Window and two off-axis fields.
The model fits essentially all the available data within the innermost 3 kpc.
The axis ratio and the morphology of the projected density contours of the COBE
bar are recovered to good accuracy within corotation. The kinematic quantities
- the line-of-sight streaming velocity and velocity dispersion, as well as the
proper motions when available - are recovered, not merely for the fitted
fields, but also for three new fields. The dynamical model deviates most from
the input density close to the Galactic plane just outside corotation, where
the deprojection of the surface photometry is suspect. The dynamical model does
not reproduce the kinematics at the most distant window, where disk
contamination may be severe.Comment: 20 pages, 5 gif figures, 11 postscript figures, submitted to MNRAS.
Zipped postscript available at
http://www-thphys.physics.ox.ac.uk/users/RalfHafner/paper.ps.g
Generalized van der Waals theory of liquid-liquid phase transitions
In the framework of the thermodynamic perturbation theory for fluids we study
how the phase diagram of an isotropic repulsive soft-core attractive potential,
where a liquid-liquid phase transition exists in addition to the standard
gas-liquid phase transition, changes by varying the parameters of the
potential. We show that existence of the liquid-liquid transition is determined
by the interplay of the parameters of the potential and the structure of a
reference liquid.Comment: 5 pages, 6 figure
Phase Separation in Charge-Stabilized Colloidal Suspensions: Influence of Nonlinear Screening
The phase behavior of charge-stabilized colloidal suspensions is modeled by a
combination of response theory for electrostatic interparticle interactions and
variational theory for free energies. Integrating out degrees of freedom of the
microions (counterions, salt ions), the macroion-microion mixture is mapped
onto a one-component system governed by effective macroion interactions. Linear
response of microions to the electrostatic potential of the macroions results
in a screened-Coulomb (Yukawa) effective pair potential and a one-body volume
energy, while nonlinear response modifies the effective interactions [A. R.
Denton, \PR E {\bf 70}, 031404 (2004)]. The volume energy and effective pair
potential are taken as input to a variational free energy, based on
thermodynamic perturbation theory. For both linear and first-order nonlinear
effective interactions, a coexistence analysis applied to aqueous suspensions
of highly charged macroions and monovalent microions yields bulk separation of
macroion-rich and macroion-poor phases below a critical salt concentration, in
qualitative agreement with predictions of related linearized theories [R. van
Roij, M. Dijkstra, and J.-P. Hansen, \PR E {\bf 59}, 2010 (1999); P. B. Warren,
\JCP {\bf 112}, 4683 (2000)]. It is concluded that nonlinear screening can
modify phase behavior but does not necessarily suppress bulk phase separation
of deionized suspensions.Comment: 14 pages of text + 9 figure
Nonlinear Screening and Effective Electrostatic Interactions in Charge-Stabilized Colloidal Suspensions
A nonlinear response theory is developed and applied to electrostatic
interactions between spherical macroions, screened by surrounding microions, in
charge-stabilized colloidal suspensions. The theory describes leading-order
nonlinear response of the microions (counterions, salt ions) to the
electrostatic potential of the macroions and predicts microion-induced
effective many-body interactions between macroions. A linear response
approximation [Phys. Rev. E 62, 3855 (2000)] yields an effective pair potential
of screened-Coulomb (Yukawa) form, as well as a one-body volume energy, which
contributes to the free energy. Nonlinear response generates effective
many-body interactions and essential corrections to both the effective pair
potential and the volume energy. By adopting a random-phase approximation (RPA)
for the response functions, and thus neglecting microion correlations,
practical expressions are derived for the effective pair and triplet potentials
and for the volume energy. Nonlinear screening is found to weaken repulsive
pair interactions, induce attractive triplet interactions, and modify the
volume energy. Numerical results for monovalent microions are in good agreement
with available ab initio simulation data and demonstrate that nonlinear effects
grow with increasing macroion charge and concentration and with decreasing salt
concentration. In the dilute limit of zero macroion concentration,
leading-order nonlinear corrections vanish. Finally, it is shown that nonlinear
response theory, when combined with the RPA, is formally equivalent to the
mean-field Poisson-Boltzmann theory and that the linear response approximation
corresponds, within integral-equation theory, to a linearized hypernetted-chain
closure.Comment: 30 pages, 8 figures, Phys. Rev. E (in press
Multipole nonlinearity of metamaterials
We report on the linear and nonlinear optical response of metamaterials
evoked by first and second order multipoles. The analytical ground on which our
approach bases permits for new insights into the functionality of
metamaterials. For the sake of clarity we focus here on a key geometry, namely
the split-ring resonator, although the introduced formalism can be applied to
arbitrary structures. We derive the equations that describe linear and
nonlinear light propagation where special emphasis is put on second harmonic
generation. This contribution basically aims at stretching versatile and
existing concepts to describe light propagation in nonlinear media towards the
realm of metamaterials.Comment: 7 pages, 3 figure
miR-CATCH: microRNA capture affinity technology.
Several experimental methods exist to explore the microRNA (miRNA) regulome. These methods almost exclusively focus on multiple targets bound to a single, or perhaps a few miRNAs of interest. Here, we describe a microRNA capture affinity technology (miR-CATCH) which uses an affinity capture oligonucleotide to co-purify a single target messenger RNA (mRNA) together with all its endogenously bound miRNAs. This bench-top method is similar to RNA immunoprecipitation (RIP) and provides an experimental alternative to computational miRNA target prediction
How mRNA localization and protein synthesis sites influence dendritic protein distribution and dynamics
In this issue ofNeuron,Fonkeu et al. (2019)present a mathematical model of mRNA and protein synthesis,degradation, diffusion, and trafficking in neuronal dendrites. The model can predict the spatial distributionand temporal dynamics of proteins along dendrites. The authors use the model to account forin situimagingdata of CaMKII⍺mRNA and protein in hippocampal neurons
Cytotoxic effect of 13α-estrane derivatives on breast, endometrial and ovarian cancer cell lines
Hormone-dependent cancers such as breast, uterine, and ovarian cancers account for more than 35% of all cancers in women. Worldwide, these cancers occur in more than 2.7 million women/year and account for 22% of cancer-related deaths/year. The generally accepted mechanism for the pathophysiology of estrogen-dependent cancers is estrogen receptor-mediated cell proliferation associated with an increased number of mutations. Therefore, drugs that can interfere with either local estrogen formation or estrogen action via estrogen receptors are needed. Estrane derivatives that have low or minimal estrogenic activity can affect both pathways. In this study, we investigated the effect of 36 different estrane derivatives on the proliferation of eight breast, endometrial, and ovarian cancer cell lines and the corresponding three control cell lines. Estrane derivatives 3 and 4_2Cl showed a stronger effect on the endometrial cancer cell lines KLE and Ishikawa, respectively, compared with the control cell line HIEEC, with IC50 values of 32.6 microM and 17.9 microM, respectively. Estrane derivative 4_2Cl was most active in the ovarian cancer cell line COV362 compared to the control cell line HIO80 with an IC50 value of 3.6 microM. In addition, estrane derivative 2_4I showed a strong antiproliferative effect on endometrial and ovarian cancer cell lines, while the effect on the control cell line was slight or absent. The addition of halogen at carbon 2 and/or 4 in estrane derivatives 1 and 2 increased the selectivity for endometrial cancer cells. Overall, these results suggest that single estrane derivatives are efficient cytotoxic agents for endometrial and ovarian cancer cell lines, and thus potential lead compounds for drug development. © 2023 The Author
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