Analysis of data collected in the European Society for Blood and Marrow Transplantation (EBMT) Registry on a cohort of lymphoma patients receiving plerixafor

Plerixafor + granulocyte-colony stimulating factor (G-CSF) is administered to patients with lymphoma who are poor mobilizers of hematopoietic stem cells (HSCs) in Europe. This international, multicenter, non-interventional registry study (NCT01362972) evaluated long-term follow-up of patients with lymphoma who received plerixafor for HSC mobilization versus other mobilization methods. Propensity score matching was conducted to balance baseline characteristics between comparison groups. The following mobilization regimens were compared: G-CSF + plerixafor (G + P) versus G-CSF alone; G + P versus G-CSF + chemotherapy (G + C); and G-CSF + plerixafor + chemotherapy (G + P + C) versus G + C. The primary outcomes were progression-free survival (PFS), overall survival (OS), and cumulative incidence of relapse (CIR). Overall, 313/3749 (8.3%) eligible patients were mobilized with plerixafor-containing regimens. After propensity score matching, 70 versus 36 patients were matched in the G + P versus G-CSF alone cohort, 124 versus 124 in the G + P versus G + C cohort, and 130 versus 130 in the G + P + C versus G + C cohort. For both PFS and OS, the upper bound of confidence interval for the hazard ratio was >1.3 for all comparisons, implying that non-inferiority was not demonstrated. No major differences in PFS, OS, and CIR were observed between the plerixafor and comparison groups

Low-Power Maximum Power Point Tracker with Digital Control for Thermophotovoltaic Generators

This paper describes the design, optimization, and evaluation of the power electronics circuitry for a low-power portable thermophotovotaic (TPV) generator system. TPV system is based on a silicon micro-reactor design and low-bandgap photovoltaic (PV) diodes. We outline critical system-level challenges associated with TPV power generation, and propose a power electronics architecture that addresses these challenges. We present experimental data from a compact, highly efficient peak power tracker and show how the proposed architecture enables increased energy extraction compared to conventional methods. The operation of the power tracker is verified with low-bandgap PV cells illuminated by a quartz halogen lamp producing a PV diode output power of 0.5 W, and above 99% tracking efficiency is demonstrated. Additionally, the complete system operation is verified with the power tracker connected to GaInAsSb PV diodes and a silicon micro-reactor, producing 150 mW of electrical power.United States. Army Research OfficeMassachusetts Institute of Technology. Institute for Soldier Nanotechnologie

Fabrication of two-dimensional tungsten photonic crystals for high-temperature applications

This article details microfabrication of two-dimensional tungsten photonic crystals (2D W PhCs) for high-temperature applications such as selective thermal emitters for thermophotovoltaic energy conversion. In particular, interference lithography and reactive ion etching are used to produce large area single crystal tungsten 2D PhCs. For this investigation, we fabricated a 2D W PhC sample consisting of an array of cylindrical cavities with 800 nm diameter, 1.2 lm depth, and 1.2 lm period. Extensive characterization and calibration of all microfabrication steps are presented. Experimentally obtained thermal emissivity spectrum is shown to match well with numerical simulations

Toward high-energy-density, high-efficiency, and moderate-temperature chip-scale thermophotovoltaics

The challenging problem of ultra-high-energy-density, high-efficiency, and small-scale portable power generation is addressed here using a distinctive thermophotovoltaic energy conversion mechanism and chip-based system design, which we name the microthermophotovoltaic (μTPV) generator. The approach is predicted to be capable of up to 32% efficient heat-to-electricity conversion within a millimeter-scale form factor. Although considerable technological barriers need to be overcome to reach full performance, we have performed a robust experimental demonstration that validates the theoretical framework and the key system components. Even with a much-simplified μTPV system design with theoretical efficiency prediction of 2.7%, we experimentally demonstrate 2.5% efficiency. The μTPV experimental system that was built and tested comprises a silicon propane microcombustor, an integrated high-temperature photonic crystal selective thermal emitter, four 0.55-eV GaInAsSb thermophotovoltaic diodes, and an ultra-high-efficiency maximum power-point tracking power electronics converter. The system was demonstrated to operate up to 800 °C (silicon microcombustor temperature) with an input thermal power of 13.7 W, generating 344 mW of electric power over a 1-cm[superscript 2] area.Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies (Contract W911NF-07-D-0004)nited States. Dept. of Energy. Office of Science (Solid-State Solar-Thermal Energy Conversion Center Grant DE-SC0001299