7,683 research outputs found
Estimating student workload during the learning design of online courses:Creating a student workload calculator
UK university students are expected to undertake 10 hours of work for each Credit Accumulation and Transfer Scheme (CATS) credit. With face-to-face learning, this is relatively easy to quantify as x hours of contact time and the remainder made up of independent study. For online and distance learning, this is more complex. Study materials are provided for students to work through independently, but unlike face-to-face where the class ends after an hour or two, online students could continue working indefinitely. Some students will inevitably take longer than others to complete tasks, and it is therefore more difficult to ensure student workload in online courses is proportionate to the credits awarded. This paper provides a means to calculate student workload in online courses via a workload calculator, derived from a review of the literature and available at http://bit.ly/postgradworkload. It uses Laurillardâs (2009, 2013) conversational framework activity types to categorise online course materials into task types, and provides a means of estimating the time it would take an average student to complete each task, for use in informing the design of online courses. For those task types that cannot be accurately estimated it is recommended to provide guidance on how long a student should spend on the task within the learning materials
Effect of disorder on the electronic properties of graphene: a theoretical approach
In order to manipulate the properties of graphene, its very important to
understand the electronic structure in presence of disorder. We investigate,
within a tight-binding description, the effects of disorder in the on-site
(diagonal disorder) term in the Hamiltonian as well as in the hopping integral
(off-diagonal disorder) on the electronic dispersion and density of states by
augmented space recursion method. Extrinsic off-diagonal disorder is shown to
have dramatic effects on the two-dimensional Dirac-cone, including asymmetries
in the band structures as well as the presence of discontinuous bands in
certain limits. Disorder-induced broadening, related to the scattering length
(or life-time) of electrons, is modified significantly with the increasing
strength of disorder. We propose that our theory is suitable to study the
effects of disorder in other 2D materials, e.g., a boron nitride monolayer.Comment: 11 pages, 8 figure
The hyaluronan-binding serine protease from human plasma cleaves HMW and LMW kininogen and releases bradykinin
The influence of the hyaluronanbinding protease (PHBSP), a plasma enzyme with FVII- and pro-urokinase-activating potency, on components of the contact phase (kallikrein/kinin) system was investigated. No activation or cleavage of the proenzymes involved in the contact phase system was observed. The procofactor high molecular weight kininogen (HK), however, was cleaved in vitro by PHBSP in the absence of any charged surface, releasing the activated cofactor and the vasoactive nonapeptide bradykinin. Glycosoaminoglycans strongly enhanced the reaction. The cleavage was comparable to that of plasma kallikrein, but clearly different from that of coagulation factor FXIa. Upon extended incubation with PHBSP, the light chain was further processed, partially removing about 60 amino acid residues from the Nterminus of domain D5 of the light chain. These cleavage site(s) were distinct from plasma kallikrein or FXIa cleavage sites. PHBSP and, more interestingly, also plasma kallikrein could cleave low molecular weight kininogen in vitro, indicating that domains D5(H) and D6(H) are no prerequisite for kininogen cleavage. PHBSP was also able to release bradykinin from HK in plasma where the pro-cofactor circulates predominantly in complex with plasma kallikrein or FXI. In conclusion, PHBSP represents a novel kininogen-cleaving and bradykinin-releasing enzyme in plasma that shares significant catalytic similarities with plasma kallikrein. Since they are structurally unrelated in their heavy chains (propeptide), their similar in vivo catalytic activities might be directed at distinct sites where PHBSP could induce processes that are related to the kallikrein/kinin system
Negotiation in Multi-Agent Systems
In systems composed of multiple autonomous agents, negotiation is a key form of interaction that enables groups of agents to arrive at a mutual agreement regarding some belief, goal or plan, for example. Particularly because the agents are autonomous and cannot be assumed to be benevolent, agents must influence others to convince them to act in certain ways, and negotiation is thus critical for managing such inter-agent dependencies. The process of negotiation may be of many different forms, such as auctions, protocols in the style of the contract net, and argumentation, but it is unclear just how sophisticated the agents or the protocols for interaction must be for successful negotiation in different contexts. All these issues were raised in the panel session on negotiation
Spiritually informed not-for-profit performance measurement
Performance measurement has far-reaching implications for not-for-profit organizations because it serves to legitimize, attract resources, and preserve expectations of stakeholders. However, the existing theory and practice of not-for-profit performance measurement have fallen short, due in part, to an overuse of profit-oriented philosophies. Therefore, we examine not-for-profit performance measurement by utilizing Marquesâ (J Bus Ethics 92:211â225, 2010) âfive spiritual practices of Buddhism.â Marquesâ spiritual practicesâa pro-scientific philosophy, greater personal responsibility, healthy detachment, collaboration, and embracing a wholesome viewâare the foundation of our research design. Responses from senior not-for-profit practitioners (n = 63) support the linkages between spiritual practices and not-for-profit performance measurement. We identify three essential performance measurement principles and elaborate on their capacity to generate awareness, higher meaning, and connectedness within not-for-profits
The geometrical accuracy of a custom artificial intervertebral disc implant manufactured using Computed Tomography and Direct Metal Laser Sintering
Published ArticleRapid Manufacturing (RM) has emerged over the past few years as a potential technology to successfully produce patient-specific implants for maxilla/facial and cranial reconstructive surgeries. However, in the area of spinal implants, customization has not yet come to the forefront and with growing capabilities in both software and manufacturing technologies, these opportunities need to be investigated and developed wherever possible.
The possibility of using Computed Tomography (CT) and Rapid Manufacturing (RM) technologies to design and manufacture a customized, patient-specific intervertebral implant, is investigated. Customized implants could aid in the efforts to reduce the risk of implant subsidence, which is a concern with existing standard implants. This article investigates how accurately the geometry of a customized artificial intervertebral disc (CAID) can represent the inverse geometry of a patient's vertebral endplates. The results indicate that the endplates of a customized disc implant can be manufactured to a calculated average error of 0.01mm within a confidence interval of 0.022mm, with 95% confidence, when using Direct Metal Laser Sintering
Attractor Metadynamics in Adapting Neural Networks
Slow adaption processes, like synaptic and intrinsic plasticity, abound in
the brain and shape the landscape for the neural dynamics occurring on
substantially faster timescales. At any given time the network is characterized
by a set of internal parameters, which are adapting continuously, albeit
slowly. This set of parameters defines the number and the location of the
respective adiabatic attractors. The slow evolution of network parameters hence
induces an evolving attractor landscape, a process which we term attractor
metadynamics. We study the nature of the metadynamics of the attractor
landscape for several continuous-time autonomous model networks. We find both
first- and second-order changes in the location of adiabatic attractors and
argue that the study of the continuously evolving attractor landscape
constitutes a powerful tool for understanding the overall development of the
neural dynamics
Product and process innovations by means of rapid technologies
Published ArticleOver the past few years, methods of layered manufacturing (LM) have advanced substantially to the point where they now provide vital strategic benefits to various organisations. One area of application where LM technologies have begun to reach a critical mass is in the development and production of high-performance tooling in different forming processes. With these tooling capabilities now available, the next challenge becomes the development of optimal process chains to minimise lead times and production costs, while still ensuring high quality of castings. The relevant issues that influence where a break-even point will be between different process chains and thereby also the point of selection between such optimal process chains according to different situations include among others: the size of production runs, part size and complexity, and the cast materials involved. This paper reflects some of the experiences gained from an investigation towards developing a set of generic rules (guidelines) for the design of optimal process chains for sand casting prototypes of automotive components using LM methods, and more specifically the 3D Printing process
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