Semiotics Analysis of Cibuntu Tourism Village Logo

Cibuntu Tourism Village is located in Pesawahan District, Kuningan Regency, West Java. Its ancient heritage and racial landscape have made the Cibuntu Tourism Village win national and international awards in the community-based tourism category. In this study, the visual identity of Cibuntu Tourism Village was dissected and analyzed using the semiotics perspective of Roland Barthes. Data collection techniques in this study used interviews, observation and literature reviews. Through semiotics analysis it was found that the Cibuntu Tourism Village logo did not represent the characteristics of the village. Further research is needed in the form of designing visual identity with the rules of the logo with the approach of natural characteristics and the warmth of the village has made it easier for consumers to reflect on the experience of visiting this village. Keywords: Logo, Semiotics, Cibuntu Villag

Grad-CAM++: Improved Visual Explanations for Deep Convolutional Networks

Over the last decade, Convolutional Neural Network (CNN) models have been highly successful in solving complex vision problems. However, these deep models are perceived as "black box" methods considering the lack of understanding of their internal functioning. There has been a significant recent interest in developing explainable deep learning models, and this paper is an effort in this direction. Building on a recently proposed method called Grad-CAM, we propose a generalized method called Grad-CAM++ that can provide better visual explanations of CNN model predictions, in terms of better object localization as well as explaining occurrences of multiple object instances in a single image, when compared to state-of-the-art. We provide a mathematical derivation for the proposed method, which uses a weighted combination of the positive partial derivatives of the last convolutional layer feature maps with respect to a specific class score as weights to generate a visual explanation for the corresponding class label. Our extensive experiments and evaluations, both subjective and objective, on standard datasets showed that Grad-CAM++ provides promising human-interpretable visual explanations for a given CNN architecture across multiple tasks including classification, image caption generation and 3D action recognition; as well as in new settings such as knowledge distillation.Comment: 17 Pages, 15 Figures, 11 Tables. Accepted in the proceedings of IEEE Winter Conf. on Applications of Computer Vision (WACV2018). Extended version is under review at IEEE Transactions on Pattern Analysis and Machine Intelligenc

Development of Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) Methods to Study Pathophysiology Underlying Neurodegenerative Diseases in Murine Models

Manganese-enhanced magnetic resonance imaging (MEMRI) opens the great opportunity to study complex paradigms of central nervous system (CNS) in freely behaving animals and reveals new pathophysiological information that might be otherwise difficult to gain. Due to advantageous chemical and biological properties of manganese (Mn2+), MEMRI has been successfully applied in the studies of several neurological diseases using translational animal models to assess comprehensive information about neuronal activity, morphology, neuronal tracts, and rate of axonal transport. Although previous studies highlight the potential of MEMRI for brain imaging, the limitations concerning the use of Mn2+ in living animals and applications of MEMRI in neuroscience research are in their infancy. Therefore, development of MEMRI methods for experimental studies remains essential for diagnostic findings, development of therapeutic as well as pharmacological intervention strategies. Our lab has been dedicating to develop novel MEMRI methods to study the pathophysiology underlying neurodegenerative diseases in murine models. In the first study, we investigated the cellular mechanism of MEMRI signal change during neuroinflammation in mice. The roles of neural cells (glia and neurons) in MEMRI signal enhancement were delineated, and ability of MEMRI to detect glial (astrocyte and microglia) and neuronal activation was demonstrated in mice treated with inflammatory inducing agents. In vitro work demonstrated that cytokine-induced glial activation facilitates neuronal uptake of Mn2+,and that glial Mn2+ content was not associated with glial activation. The in vivo work confirmed that MEMRI signal enhancement in the CNS is induced by astrocytic activation by stimulating neuronal Mn2+ uptake. In conclusion, our results supported the notion that MEMRI reflects neuronal excitotoxicity and impairment that can occur through a range of insults that include neuroinflammation. In the second study, we evaluated the efficacy of MEMRI in diagnosing the complexities of neuropathology in an ananimal model of a neurodegenerative disease, neuroAIDS. This study demonstrated that MEMRI reflects brain region specific HIV-1-induced neuropathology in virus-infected NOD/scid-IL-2Rγcnull humanized mice. Altered MEMRI signal intensity was observed in affected brain regions. These included, but were not limited to, the hippocampus, amygdala, thalamus, globus pallidus, caudoputamen, substantia nigra and cerebellum. MEMRI signal was coordinated with levels of HIV-1 infection, neuroinflammation (astro- and micro- gliosis), and neuronal injury. Following the application of MEMRI to assess HIV-1 induced neuropathology in immune deficient mice humanized with lymphoid progenitor cells, our successful collaboration with Dr. Sajja BR (Department of Radiology, UNMC, Omaha, NE) led to the generation of a MEMRI-based NOD/scid-IL-2Rγcnull (NSG) mouse brain atlas. Mouse brain MRI atlases allow longitudinal quantitative analyses of neuroanatomical volumes and imaging metrics. As NSG mice allow human cell transplantation to study human disease, these animals are used to assess brain morphology. MEMRI provided sufficient contrast permitting 41 brain structures to be manually labeled on average brain of 19 mice using alignment algorithm. The developed atlas is now made available to researchers through Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) website (https://www.nitrc.org/projects/memribrainatlas/). Finally, we evaluated the efficacy of N-acetylated-para-aminosalicylic acid (AcPAS) to accelerate Mn2+ elimination from rodent brain, enabling repeated use of MEMRI to follow the CNS longitudinally in weeks or months as well as inhibiting the confounding effects of residual Mn2+ from preceding administrations on imaging results. Two-week treatment with AcPAS (200 mg/kg/dose × 3 daily) accelerated the decline of Mn2+ induced enhancement in MRI. This study demonstrated that AcPAS could enhance MEMRI utility in evaluating brain biology in small animals

Perjanjian Pengikatan Jual Beli Dan Kuasa Menjual Sebagai Bentuk Perlindungan Hukum Bagi Pembeli Tanah Kaveling Di Kota Denpasar

In the process, Subdivision of land is not only carried out by a legal entity that has been qualified developers, but also undertaken by individuals who have sufficient capital to it. On one hand, Subdivision of land by the private benefit greatly assist the government in accelerating the equalization needs of the population will be a place to stay, but there are also land issues that arise because of the process Subdivision by the individual parties. The purpose of this paper is to understand, analyze, why binding agreement of sale and purchase and the power to sell was made prior to the deed of sale by PPAT, and find answers to obstacles that may hinder the making of the deed of sale after he made binding agreement of sale and purchase and power the buying and selling land plot in the city of Denpasar and efforts of its solution. While the benefits of this research are expected to be able to add information to the parties involved in the registration of transfer of rights for the land. The approach used method is the juridical sociology. Based on the research that has been done, it can be concluded that the binding sale and purchase agreement and the power was made before the deed of sale PPAT in terms of buying and selling land plot in the city of Denpasar created to bridge before the purchase is done before PPAT. And the obstacles that hinder the making of the deed of sale by the official land deed that is because of the subject transaction that is caused by an imbalance in the fulfillment of the rights and obligations of the parties in the sale and purchase of land plot and because the object of the sale and purchase due to the technical procedures such as applications for permission plot and solving certificates that are not performing well in the process Subdivision

Severity of Spinal Cord Injury Influences Diffusion Tensor Imaging of the Brain

Background: The purpose of this study was to determine whether DTI changes in the brain induced by a thoracic spinal cord injury are sensitive to varying severity of spinal contusion in rats. Methods: A control, mild, moderate, or severe contusion injury was administered over the eighth thoracic vertebral level in 32 Sprague-Dawley rats. At 11 weeks postinjury, ex vivo DTI of the brain was performed on a 9.4T Bruker scanner using a pulsed gradient spin-echo sequence. Results: Mean water diffusion in the internal capsule regions of the brain and pyramid locations of the brainstem were correlated with motor function (r2 = 0.55). Additionally, there were significant differences between injury severity groups for mean diffusivity and fractional anisotropy at regions associated with the corticospinal tract (P = 0.05). Conclusion: These results indicate that DTI is sensitive to changes in brain tissue as a consequence of thoracic SCI