The effect of oral chronic graft-versus-host disease on bodyweight: A cohort study.

AimThis retrospective cohort study aimed to evaluate the association between body weight and oral cGVHD (chronic graft versus host disease).MethodsPatients with oral cGVHD were compared with an age and gender-matched non-GVHD cohort in terms of demographic information, body mass index (BMI), date of transplant, length of hospitalization, and oral complications. Weight was stratified in pre-and post-transplant weight, mean weight after acquiring cGVHD for the first year, and post-oral cGVHD BMI. Each patient was matched and compared with two controls at a 1:2 ratio. Firth's penalized likelihood logistic regression was used to investigate the association between oral complications and weight loss greater than 5% in the oral cGVHD group.ResultsThis study included 137 patients (n = 42 oral cGVHD, n = 12 non oral-cGVHD and n = 83 non-GVHD). The oral cGVHD cohort had a 1.44 times higher risk (RR) of being underweight (BMIConclusionThe weight loss was more prevalent among oral cGVHD, and oral mucositis was linked to significant weight loss. Weight loss may indicate the need to initiate early and aggressive symptomatic oral cGVHD treatment

Characteristics and outcomes of the matched cohorts.

Characteristics and outcomes of the matched cohorts.</p

Two cohorts stratified by weight category.

AimThis retrospective cohort study aimed to evaluate the association between body weight and oral cGVHD (chronic graft versus host disease).MethodsPatients with oral cGVHD were compared with an age and gender-matched non-GVHD cohort in terms of demographic information, body mass index (BMI), date of transplant, length of hospitalization, and oral complications. Weight was stratified in pre-and post-transplant weight, mean weight after acquiring cGVHD for the first year, and post-oral cGVHD BMI. Each patient was matched and compared with two controls at a 1:2 ratio. Firth’s penalized likelihood logistic regression was used to investigate the association between oral complications and weight loss greater than 5% in the oral cGVHD group.ResultsThis study included 137 patients (n = 42 oral cGVHD, n = 12 non oral-cGVHD and n = 83 non-GVHD). The oral cGVHD cohort had a 1.44 times higher risk (RR) of being underweight (BMIConclusionThe weight loss was more prevalent among oral cGVHD, and oral mucositis was linked to significant weight loss. Weight loss may indicate the need to initiate early and aggressive symptomatic oral cGVHD treatment.</div

Unadjusted odds ratios (uOR), adjusted odds ratios (aOR), and 95% confidence interval (95% CI) of the oral complications associated with >5% weight loss in patients with oral graft-versus-host disease.

Unadjusted odds ratios (uOR), adjusted odds ratios (aOR), and 95% confidence interval (95% CI) of the oral complications associated with >5% weight loss in patients with oral graft-versus-host disease.</p

Patient and cGVHD characteristics.

AimThis retrospective cohort study aimed to evaluate the association between body weight and oral cGVHD (chronic graft versus host disease).MethodsPatients with oral cGVHD were compared with an age and gender-matched non-GVHD cohort in terms of demographic information, body mass index (BMI), date of transplant, length of hospitalization, and oral complications. Weight was stratified in pre-and post-transplant weight, mean weight after acquiring cGVHD for the first year, and post-oral cGVHD BMI. Each patient was matched and compared with two controls at a 1:2 ratio. Firth’s penalized likelihood logistic regression was used to investigate the association between oral complications and weight loss greater than 5% in the oral cGVHD group.ResultsThis study included 137 patients (n = 42 oral cGVHD, n = 12 non oral-cGVHD and n = 83 non-GVHD). The oral cGVHD cohort had a 1.44 times higher risk (RR) of being underweight (BMIConclusionThe weight loss was more prevalent among oral cGVHD, and oral mucositis was linked to significant weight loss. Weight loss may indicate the need to initiate early and aggressive symptomatic oral cGVHD treatment.</div

Unadjusted odds ratios (uOR), adjusted odds ratios (aOR), and their respective 95% confidence intervals (95% CI) of the involvement of oral cGVHD with and without GIT associated with >5% weight loss in patients with oral graft-versus-host disease.

Unadjusted odds ratios (uOR), adjusted odds ratios (aOR), and their respective 95% confidence intervals (95% CI) of the involvement of oral cGVHD with and without GIT associated with >5% weight loss in patients with oral graft-versus-host disease.</p

Flow chart of study design.

AimThis retrospective cohort study aimed to evaluate the association between body weight and oral cGVHD (chronic graft versus host disease).MethodsPatients with oral cGVHD were compared with an age and gender-matched non-GVHD cohort in terms of demographic information, body mass index (BMI), date of transplant, length of hospitalization, and oral complications. Weight was stratified in pre-and post-transplant weight, mean weight after acquiring cGVHD for the first year, and post-oral cGVHD BMI. Each patient was matched and compared with two controls at a 1:2 ratio. Firth’s penalized likelihood logistic regression was used to investigate the association between oral complications and weight loss greater than 5% in the oral cGVHD group.ResultsThis study included 137 patients (n = 42 oral cGVHD, n = 12 non oral-cGVHD and n = 83 non-GVHD). The oral cGVHD cohort had a 1.44 times higher risk (RR) of being underweight (BMIConclusionThe weight loss was more prevalent among oral cGVHD, and oral mucositis was linked to significant weight loss. Weight loss may indicate the need to initiate early and aggressive symptomatic oral cGVHD treatment.</div