Change-Point Analysis of Tropical Night Occurrences for Five Major Cities in Republic of Korea

Bayesian change-point analysis is applied to detect a change-point in the occurrences of tropical night (TN) days in the 50-year time series data for five major cities in Republic of Korea. A TN day is simply defined as a day when the daily minimum temperature is greater than 25∘C. A Bayesian analysis is performed for detecting a change-point at an unknown time point in the TN day frequency time series, which is modeled by an independent Poisson random variable. The results showed that a single change occurred around 1993 for three cities (Seoul, Incheon, and Daegu). However, when we excluded the extraordinary year, 1994, a single change occurred around 1993 only in Seoul and Daegu. The average number of TN days in Seoul and Daegu increased significantly, by more than 150%, after the change-point year. The abrupt increase in TN day frequency in two cities over Republic of Korea around 1993 may be related to the significant decadal change in the East Asian summer monsoon around the mid 1990s and to rapid urbanization

Regional Climate Model Intercomparison Project for Asia

Improving the simulation of regional climate change is one of the high-priority areas of climate study because regional information is needed for climate change impact assessments. Such information is especially important for the region covered by the East Asian monsoon where there is high variability in both space and time. To this end, the Regional Climate Model Intercomparison Project (RMIP) for Asia has been established to evaluate and improve regional climate model (RCM) simulations of the monsoon climate. RMIP operates under joint support of the Asia–Pacific Network for Global Change Research (APN), the Global Change System for Analysis, Research and Training (START), the Chinese Academy of Sciences, and several projects of participating nations. The project currently involves 10 research groups from Australia, China, Japan, South Korea, and the United States, as well as scientists from India, Italy, Mongolia, North Korea, and Russia. RMIP has three simulation phases: March 1997–August 1998, which covers a full annual cycle and extremes in monsoon behavior; January 1989–December 1998, which examines simulated climatology; and a regional climate change scenario, involving nesting with a global model. This paper is a brief report of RMIP goals, implementation design, and some initial results from the first phase studies

Protective Effects of Platycodon grandiflorum Aqueous Extract on Thioacetamide-induced Fulminant Hepatic Failure in Mice

The aim of the present study was to evaluate the protective activity of aqueous extract from Platycodon grandiflorum (BC703) on thioacetamide (TA)-induced hepatotoxicity in mice. We found that BC703 significantly decreased mortality and the change in serum transaminase following TA administration. The group treated with BC703 at doses of 1, 5, and 10 mg/kg produced significant hepatoprotective effects against TA-induced liver damage by decreasing the activities of serum enzymes, nitric oxide and lipid peroxidation in dose-dependent manners. Histopathological studies further substantiated the protective effect of BC703. These results show the hepatoprotective activity of aqueous extract from Platycodon grandiflorum on thioacetamide-induced fulminant hepatic failure

In vivo metabolism of Talosin A, new isoflavonol glycoside from Kitasatospora kifunensis, in rats

The isoflavonol glycoside Talosin A, genistein (GT)-7-α-L-6-deoxy talopyranose (GT-Tal), was first isolated from the culture broth of Kitasatospora kifunensis MJM341. The aim of the present study was to evaluate the oral absorption and metabolism of the newly isolated isoflavonol glycoside, GT-Tal compared to genistin (GT-7-O-β-D-glucopyranoside; GT-Glu). Free GT-Glu and GT-Tal could not be detected prior to enzymatic hydrolysis of the corresponding conjugates in rat plasma. Following oral administration of GT-Tal (15 min), GT-Tal was rapidly absorbed through the gastrointestinal tract and metabolized into GT-Tal conjugates with a mean Cmax of 2.74 µg/mL. GT-Tal was further metabolized to its aglycone, free GT and conjugated GT. After oral administration, GT-Glu was absorbed after being convereted to its aglycone and then further metabolized into its conjugate metabolites (free GT with a mean Cmax of 0.24 mg/mL at 1.25 h; conjugated GT with a mean Cmax of 1.31 mg/mL at 2.00 h). Significant differences in absorption and metabolism of GT-Tal and GT-Glu were observed. GT-Tal was metabolized into its corresponding conjugates or underwent deglycosylation to form GT, whereas GT-Glu was metabolized into its aglycone, GT

Immunogenicity of influenza vaccination in patients with cancer receiving immune checkpoint inhibitors

Among prospectively enrolled adult patients with cancer receiving immune checkpoint inhibitors (ICIs; n = 46) or cytotoxic agents (n = 90), seroprotection and seroconversion rates after seasonal quadrivalent influenza vaccinations were higher with ICI than with cytotoxic chemotherapy. These results support annual influenza vaccinations for cancer patients receiving ICIs.

Climatic yield potential of Japonica???type rice in the Korean Peninsula under RCP scenarios using the ensemble of multi???GCM and multi???RCM chains

Rice production in the Korean Peninsula (KP) in the near future (2021-2050) is analysed in terms of the climatic yield potential (CYP) index for Japonica-type rice. Data obtained from the dynamically downscaled daily temperature and sunshine duration for the Historical period (1981-2010) and near future under two Representative Concentration Pathway (RCP4.5 and RCP8.5) scenarios are utilized. To reduce uncertainties that might be induced by using a Coupled General Circulation Model (CGCM)-a Regional Climate Model (RCM) chain in dynamical downscaling, two CGCM-three RCM chains are used to estimate the CYP index. The results show that the mean rice production decreases, mainly due to the increase of the temperature during the grain-filling period (40 days after the heading date). According to multi model ensemble, the optimum heading date in the near future will be approximately 12 days later and the maximum CYP will be even higher than in the Historical. This implies that the rice production is projected to decrease if the heading date is selected based on the optimum heading date of Historical, but to increase if based on that of near future. The mean rice production during the period of ripening is projected to decrease (to about 95% (RCP4.5) and 93% (RCP8.5) of the Historical) in the western and southern regions of the KP, but to increase (to about 104% (RCP4.5) and 106% (RCP8.5) of the Historical) in the northeastern coastal regions of the KP. However, if the optimum heading date is selected in the near future climate, the peak rice production is projected to increase (to about 105% (RCP4.5) and 104% (RCP8.5) of the Historical) in the western, southern and northeastern coastal regions of the KP, but to decrease (to about 98% (RCP4.5) and 96% (RCP8.5) of the Historical) in the southeastern coastal regions of the KP

Impacts of Boundary Conditions on the Simulation of Atmospheric Fields Using RegCM4 over CORDEX East Asia

The impacts of boundary conditions (BCs) on simulations of RegCM4 for mid-to-upper atmospheric fields over the CORDEX (COordinated Regional Downscaling EXperiment) East Asia domain were investigated using two datasets from integrations over 20 years (1989–2008) with two BCs (ERA and R2). The two datasets showed large differences for the atmospheric variables regardless of the geographic locations, heights, and seasons. The ERA dataset at 850 hPa displayed stronger northerly winds in the western Pacific Ocean, colder temperatures around northern India, and higher relative humidity compared with the R2 dataset during summer. The large differences in the BCs resulted in the significantly different simulations of RegCM4 in both surface and atmospheric variables. The temperatures and wind simulated at 850 hPa with the ERA dataset were warmer and stronger, respectively, than those simulated with the R2 dataset during summer. In addition, RegCM4 with the ERA dataset as a BC generally simulated a stronger southerly wind at 850 hPa over eastern China and more unstable environments than with the R2 dataset, and accordingly generated more precipitation over the eastern part of the domain. Contrary to the forcing data, the trends of simulated relative humidity and the mixing ratios from the two different BCs showed similar patterns irrespective of height and season. The significant impacts of the BCs on the simulation results indicate the importance of BCs in regional climate simulations

Change-Point Analysis of Tropical Night Occurrences for Five Major Cities in Republic of Korea

Bayesian change-point analysis is applied to detect a change-point in the occurrences of tropical night (TN) days in the 50-year time series data for five major cities in Republic of Korea. A TN day is simply defined as a day when the daily minimum temperature is greater than 25 ∘ C. A Bayesian analysis is performed for detecting a change-point at an unknown time point in the TN day frequency time series, which is modeled by an independent Poisson random variable. The results showed that a single change occurred around 1993 for three cities (Seoul, Incheon, and Daegu). However, when we excluded the extraordinary year, 1994, a single change occurred around 1993 only in Seoul and Daegu. The average number of TN days in Seoul and Daegu increased significantly, by more than 150%, after the change-point year. The abrupt increase in TN day frequency in two cities over Republic of Korea around 1993 may be related to the significant decadal change in the East Asian summer monsoon around the mid 1990s and to rapid urbanization

Development of Himawari-8/Advanced Himawari Imager (AHI) Land Surface Temperature Retrieval Algorithm

We developed land surface temperature (LST) retrieval algorithms based on the time of day and water vapor content using the Himawari-8/AHI (Advanced Himawari Imager) data, which is the Japanese next generation geostationary satellite. To develop the LST retrieval algorithms, we simulated the spectral radiance using the radiative transfer model (MODTRAN4) by applying the atmospheric profiles (SeeBor), diurnal variation of LST and air temperature, spectral emissivity of land surface, satellite viewing angle, and spectral response function of Himawari-8/AHI. To retrieve the LST from Himawari-8 data, a linear type of split-window method was used in this study. The Himawari-8 LST algorithms showed a high correlation coefficient (0.996), and a small bias (0.002 K) and root mean square error (RMSE) (1.083 K) between prescribed LSTs and estimated LSTs. However, the accuracy of LST algorithms showed a slightly large RMSE when the lapse rate was larger than 10 K, and the brightness temperature difference was greater than 6 K. The cross-validation of Himawari-8/AHI LST using the MODIS (Terra and Aqua Moderate Resolution Imaging Spectroradiometer) LST showed that annual mean correlation coefficient, bias, and RMSE were 0.94, +0.45 K, and 1.93 K, respectively. The performances of LST algorithms were slightly dependent on the season and time of day, generally better during the night (warm season) than during the day (cold season)