651 research outputs found
Cerulean: A hybrid assembly using high throughput short and long reads
Genome assembly using high throughput data with short reads, arguably,
remains an unresolvable task in repetitive genomes, since when the length of a
repeat exceeds the read length, it becomes difficult to unambiguously connect
the flanking regions. The emergence of third generation sequencing (Pacific
Biosciences) with long reads enables the opportunity to resolve complicated
repeats that could not be resolved by the short read data. However, these long
reads have high error rate and it is an uphill task to assemble the genome
without using additional high quality short reads. Recently, Koren et al. 2012
proposed an approach to use high quality short reads data to correct these long
reads and, thus, make the assembly from long reads possible. However, due to
the large size of both dataset (short and long reads), error-correction of
these long reads requires excessively high computational resources, even on
small bacterial genomes. In this work, instead of error correction of long
reads, we first assemble the short reads and later map these long reads on the
assembly graph to resolve repeats.
Contribution: We present a hybrid assembly approach that is both
computationally effective and produces high quality assemblies. Our algorithm
first operates with a simplified version of the assembly graph consisting only
of long contigs and gradually improves the assembly by adding smaller contigs
in each iteration. In contrast to the state-of-the-art long reads error
correction technique, which requires high computational resources and long
running time on a supercomputer even for bacterial genome datasets, our
software can produce comparable assembly using only a standard desktop in a
short running time.Comment: Peer-reviewed and presented as part of the 13th Workshop on
Algorithms in Bioinformatics (WABI2013
Entropy of Lovelock Black Holes
A general formula for the entropy of stationary black holes in Lovelock
gravity theories is obtained by integrating the first law of black hole
mechanics, which is derived by Hamiltonian methods. The entropy is not simply
one quarter of the surface area of the horizon, but also includes a sum of
intrinsic curvature invariants integrated over a cross section of the horizon.Comment: 15 pages, plain Latex, NSF-ITP-93-4
Rational foundation of GR in terms of statistical mechanic in the AdS/CFT framework
In this article, we work out the microscopic statistical foundation of the
supergravity description of the simplest 1/2 BPS sector in the AdS(5)/CFT(4).
Then, all the corresponding supergravity observables are related to
thermodynamical observables, and General Relativity is understood as a
mean-field theory. In particular, and as an example, the Superstar is studied
and its thermodynamical properties clarified.Comment: 13 pages, 6 eps figures, latex, some improvements introduced,
reference added, typos correcte
Gravitation with superposed Gauss--Bonnet terms in higher dimensions: Black hole metrics and maximal extensions
Our starting point is an iterative construction suited to combinatorics in
arbitarary dimensions d, of totally anisymmetrised p-Riemann 2p-forms (2p\le d)
generalising the (1-)Riemann curvature 2-forms. Superposition of p-Ricci
scalars obtained from the p-Riemann forms defines the maximally Gauss--Bonnet
extended gravitational Lagrangian. Metrics, spherically symmetric in the (d-1)
space dimensions are constructed for the general case. The problem is directly
reduced to solving polynomial equations. For some black hole type metrics the
horizons are obtained by solving polynomial equations. Corresponding Kruskal
type maximal extensions are obtained explicitly in complete generality, as is
also the periodicity of time for Euclidean signature. We show how to include a
cosmological constant and a point charge. Possible further developments and
applications are indicated.Comment: 13 pages, REVTEX. References and Note Adde
Fermions from Half-BPS Supergravity
We discuss collective coordinate quantization of the half-BPS geometries of
Lin, Lunin and Maldacena (hep-th/0409174). The LLM geometries are parameterized
by a single function on a plane. We treat this function as a collective
coordinate. We arrive at the collective coordinate action as well as path
integral measure by considering D3 branes in an arbitrary LLM geometry. The
resulting functional integral is shown, using known methods (hep-th/9309028),
to be the classical limit of a functional integral for free fermions in a
harmonic oscillator. The function gets identified with the classical limit
of the Wigner phase space distribution of the fermion theory which satisfies u
* u = u. The calculation shows how configuration space of supergravity becomes
a phase space (hence noncommutative) in the half-BPS sector. Our method sheds
new light on counting supersymmetric configurations in supergravity.Comment: 28 pages, 2 figures, epsf;(v3) eq. (3.3) clarified and notationally
simplified; version to appear in JHE
New supersymmetric solutions of N=2, D=5 gauged supergravity with hyperscalars
We construct new supersymmetric solutions, including AdS bubbles, in an N=2
truncation of five-dimensional N=8 gauged supergravity. This particular
truncation is given by N=2 gauged supergravity coupled to two vector multiples
and three incomplete hypermultiplets, and was originally investigated in the
context of obtaining regular AdS bubble geometries with multiple active
R-charges. We focus on cohomogeneity-one solutions corresponding to objects
with two equal angular momenta and up to three independent R-charges.
Curiously, we find a new set of zero and negative mass solitons asymptotic to
AdS_5/Z_k, for k \ge 3, which are everywhere regular without closed timelike
curves.Comment: Latex 3 times, 42 page
Singularities and closed time-like curves in type IIB 1/2 BPS geometries
We study in detail the moduli space of solutions discovered in LLM relaxing
the constraint that guarantees the absence of singularities. The solutions fall
into three classes, non-singular, null-singular and time machines with a
time-like naked singularity. We study the general features of these metrics and
prove that there are actually just two generic classes of space-times - those
with null singularities are in the same class as the non-singular metrics.
AdS/CFT seems to provide a dual description only for the first of these two
types of space-time in terms of a unitary CFT indicating the possible existence
of a chronology protection mechanism for this class of geometries.Comment: 34 pages, 7 figures, LaTeX. References adde
Black strings in asymptotically plane wave geometries
We present a class of black string spacetimes which asymptote to maximally
symmetric plane wave geometries. Our construction will rely on a solution
generating technique, the null Melvin twist, which deforms an asymptotically
flat black string spacetime to an asymptotically plane wave black string
spacetime while preserving the event horizon.Comment: 15 pages; references adde
Giant gravitons in AdS/CFT (I): matrix model and back reaction
In this article we study giant gravitons in the framework of AdS/CFT
correspondence. First, we show how to describe these configurations in the CFT
side using a matrix model. In this picture, giant gravitons are realized as
single excitations high above a Fermi sea, or as deep holes into it. Then, we
give a prescription to define quasi-classical states and we recover the known
classical solution associated to the CFT dual of a giant graviton that grows in
AdS. Second, we use the AdS/CFT dictionary to obtain the supergravity boundary
stress tensor of a general state and to holographically reconstruct the bulk
metric, obtaining the back reaction of space-time. We find that the space-time
response to all the supersymmetric giant graviton states is of the same form,
producing the singular BPS limit of the three charge Reissner-Nordstr\"om-AdS
black holes. While computing the boundary stress tensor, we comment on the
finite counterterm recently introduced by Liu and Sabra, and connect it to a
scheme-dependent conformal anomaly.Comment: 28 pages, JHEP3 class. v2: typos corrected and references adde
Geometrothermodynamics of five dimensional black holes in Einstein-Gauss-Bonnet-theory
We investigate the thermodynamic properties of 5D static and spherically
symmetric black holes in (i) Einstein-Maxwell-Gauss-Bonnet theory, (ii)
Einstein-Maxwell-Gauss-Bonnet theory with negative cosmological constant, and
in (iii) Einstein-Yang-Mills-Gauss-Bonnet theory. To formulate the
thermodynamics of these black holes we use the Bekenstein-Hawking entropy
relation and, alternatively, a modified entropy formula which follows from the
first law of thermodynamics of black holes. The results of both approaches are
not equivalent. Using the formalism of geometrothermodynamics, we introduce in
the manifold of equilibrium states a Legendre invariant metric for each black
hole and for each thermodynamic approach, and show that the thermodynamic
curvature diverges at those points where the temperature vanishes and the heat
capacity diverges.Comment: New sections added, references adde
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